Results 71 to 80 of about 123,296 (287)

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

Fixed point theorem and iterated function system in φ-metric modular space

Fixed Point Theory and Algorithms for Sciences and Engineering
We introduce and study the concept of φ-metric modular space and, then define φ-α-Meir-Keeler contraction on it and explore its fixed point. Further, we define the Hausdorff distance between two non-empty compact subsets of the considered space.
Bikramjit Acharjee, Guru Prem Prasad M
doaj   +1 more source

More on effective potentials for revolving D-branes

Journal of High Energy Physics, 2020
We continue to investigate the effective potential between a pair of Dp-branes revolving around each other by using the technique of partial modular transformation developed in our previous work.
Satoshi Iso, Noriaki Kitazawa, Hikaru Ohta, Takao Suyama   +3 more
doaj   +1 more source

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Non-Unique Fixed Point Theorems in Modular Metric Spaces [PDF]

Symmetry, 2019
This paper is devoted to the study of Ćirić-type non-unique fixed point results in modular metric spaces. We obtain various theorems about a fixed point and periodic points for a self-map on modular spaces which are not necessarily continuous and satisfy certain contractive conditions.
openaire   +1 more source

Fixed point results for generalized F-contractions in modular metric and fuzzy metric spaces [PDF]

Fixed Point Theory and Applications, 2015
AbstractThe notion of modular metric space, being a natural generalization of classical modulars over linear spaces, was recently introduced. In this paper, we introduce a generalized F-contraction in modular metric space and investigate the existence of fixed points for such contractions.
Nawab Hussain, Abdul Latif, Iram Iqbal
openaire   +2 more sources

RIPK4 function interferes with melanoma cell adhesion and metastasis

Molecular Oncology, EarlyView.
RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski, Sławomir Lasota, Ewelina Madej, Anna A. Brożyna, Małgorzata Szczygieł, Agnieszka Harazin‐Lechowska, Jan Czerbniak, Janusz Rys, Jaroslaw Czyz, Agnieszka Wolnicka‐Glubisz   +9 more
wiley   +1 more source

Navigating new norms: a systematic review of factors for the development of effective digital tools in higher education

FEBS Open Bio, EarlyView.
What factors make for an effective digital learning tool in Higher Education? This systematic review identifies elements of a digital tool that published examples reveal to be features of an engaging and impactful digital tool. A systematic literature search yielded 25 research papers for analysis.
Akmal Arzeman, Jessica Haines, Connie Pritchard, Stephen Rutherford, Nigel Francis   +4 more
wiley   +1 more source

Static Domain Walls in N=1 Supergravity

, 1992
We study supersymmetric domain walls in N=1 supergravity theories, including those with modular-invariant superpotentials arising in superstring compactifications. Such domain walls are shown to saturate the Bogomol'nyi bound of wall energy per unit area.
Abraham, Binétruy, Bogomol'nyi, Callan, Chun, Coleman, Cvetič, Cvetič, Cvetič, Dabholkar, Derendinger, Deser, Dixon, Duff, Duff, Duff, Duff, Duff, Duff, Fendley, Ferrara, Ferrara, Font, Frampton, Gibbons, Greene, Hull, Hull, Ipser, Lauer, Lerche, Mirjam Cvetič, Misner, Nester, Nilles, Ovrut, Ovrut, Rey, Rey, Rey, Rey, Schoeneberg, Soo-Jong Rey, Stephen Griffies, Strominger, Strominger, Vilenkin, Wald, Weinberg, Wess, Witten, Witten   +51 more
core   +1 more source

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

FEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz, Bart Geverts, Johan A. Slotman, Andrea Sacchetti, Stefan Prekovic, Martin E. van Royen, Adriaan B. Houtsmuller   +6 more
wiley   +1 more source