Results 61 to 70 of about 14,216 (300)
Molecular Oncology, EarlyView.Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau +36 more
wiley +1 more source
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
Higher level appell functions, modular transformations and non-unitary characters [PDF]
, 2003 In this thesis, we firstly extend elements and periodicity properties of the theta function theory to functions that represent a wider domain of symmetries and properties, graded with different amounts of p ≥ 1, p ϵ N.
Ghominejad, Mehrdad
core
BRAPH: A graph theory software for the analysis of brain connectivity. [PDF]
PLoS ONE, 2017 The brain is a large-scale complex network whose workings rely on the interaction between its various regions. In the past few years, the organization of the human brain network has been studied extensively using concepts from graph theory, where the ...
Mite Mijalkov +5 more
doaj +1 more source
On the modular representation theory of the partition algebra [PDF]
Journal of Algebraic Combinatorics, 2015 We determine the decomposition numbers of the partition algebra when the characteristic of the ground field is zero or larger than the degree of the partition algebra. This will allow us to determine for which exact values of the parameter the partition algebras are semisimple over an arbitrary field.
openaire +3 more sources
Molecular Oncology, EarlyView.Both cg12821679MAPRE3 methylation and MAPRE3 expression are significantly associated with overall survival (OS) of non‐small cell lung cancer. Meanwhile, MAPRE3 expression significantly modified the effect of smoking cessation on OS. Smoking cessation benefits OS merely for patients with high MAPRE3 expression.
Chao Chen +14 more
wiley +1 more source
On the Virasoro crossing kernels at rational central charge
SciPost PhysicsWe report novel analytic results for the Virasoro modular and fusion kernels relevant to 2d conformal field theories (CFTs), 3d topological field theories (TQFTs), and the representation theory of certain quantum groups.
Julien Roussillon, Ioannis Tsiares
doaj +1 more source
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Frontiers in Energy Research, 2021 AC/DC hybrid distribution network can realize the high penetration utilization of renewable energy and modular multilevel converter (MMC) is the key equipment to connect AC grid and DC grid.
Zhang Xianyong +7 more
doaj +1 more source
MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source