Results 61 to 70 of about 229,775 (283)

Modularity and derivation in Functional Discourse Grammar

DELTA: Documentação de Estudos em Lingüística Teórica e Aplicada
Functional Discourse Grammar (FDG) is a typologically-based theory of language structure which is organized in levels, layers and components. In this paper, I will claim that FDG is modular in Sadock’s sense, as it presents four independent levels of ...
Daniel GARCÍA VELASCO
doaj   +1 more source

BRAPH: A graph theory software for the analysis of brain connectivity. [PDF]

PLoS ONE, 2017
The brain is a large-scale complex network whose workings rely on the interaction between its various regions. In the past few years, the organization of the human brain network has been studied extensively using concepts from graph theory, where the ...
Mite Mijalkov, Ehsan Kakaei, Joana B Pereira, Eric Westman, Giovanni Volpe, Alzheimer's Disease Neuroimaging Initiative   +5 more
doaj   +1 more source

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

The algebraic chromatic splitting conjecture for Noetherian ring spectra

, 2018
We formulate a version of Hopkins' chromatic splitting conjecture for an arbitrary structured ring spectrum $R$, and prove it whenever $\pi_*R$ is Noetherian.
Barthel, Tobias, Heard, Drew, Valenzuela, Gabriel   +2 more
core   +1 more source

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Power Decoupling Control of MMC and Small-Signal Stability Analysis of AC/DC Distribution Network With Renewable Energy

Frontiers in Energy Research, 2021
AC/DC hybrid distribution network can realize the high penetration utilization of renewable energy and modular multilevel converter (MMC) is the key equipment to connect AC grid and DC grid.
Zhang Xianyong , Zhang Xianyong , Guo Zijuan , Huang Yaohong , Li Li, Peng Weikuan, Cen Jian, Cen Jian   +7 more
doaj   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Electron Beams on the Brillouin Zone: A Cohomological Approach via Sheaves of Fourier Algebras

Universe, 2023
Topological states of matter can be classified only in terms of global topological invariants. These global topological invariants are encoded in terms of global observable topological phase factors in the state vectors of electrons. In condensed matter,
Elias Zafiris, Albrecht von Müller
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Seven Properties of Self-Organization in the Human Brain

Big Data and Cognitive Computing, 2020
The principle of self-organization has acquired a fundamental significance in the newly emerging field of computational philosophy. Self-organizing systems have been described in various domains in science and philosophy including physics, neuroscience ...
Birgitta Dresp-Langley
doaj   +1 more source