Results 71 to 80 of about 14,216 (300)
Molecular Oncology, EarlyView.Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller +10 more
wiley +1 more source
Seven Properties of Self-Organization in the Human Brain
Big Data and Cognitive Computing, 2020 The principle of self-organization has acquired a fundamental significance in the newly emerging field of computational philosophy. Self-organizing systems have been described in various domains in science and philosophy including physics, neuroscience ...
Birgitta Dresp-Langley
doaj +1 more source
On the modular representation theory of algebraic Chevalley groups [PDF]
This thesis aims to provide an introduction to the modular representation theory of algebraic Chevalley groups. Chapter 1 contains the general theory so far, most of which is due to Green [6] who sets up the modular theory in the more general context of co-algebras. In chapter 2 the decomposition matrix is discussed.
Winter, Paul William
openaire +1 more source
Molecular Oncology, EarlyView.BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi +11 more
wiley +1 more source
FEBS Open Bio, EarlyView.This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill +4 more
wiley +1 more source
FEBS Open Bio, EarlyView.Bioscience students were asked for their opinions on the value and teaching of skills. 204 responded that teamwork, time management and study skills are necessary to reach University, that scientific writing, research, laboratory and presentation skills are taught effectively during their studies, while other skills are gained inherently through study ...
Janella Borrell, Susan Crennell
wiley +1 more source
Local Representation Theory and Simple Groups
The book contains extended versions of seven short lecture courses given during a semester programme on Local Representation Theory and Simple Groups, held at the Centre Interfacultaire Bernoulli of the EPF Lausanne.
Malle, Gunter +2 more
core +1 more source
FEBS Open Bio, EarlyView.Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young +7 more
wiley +1 more source
Universal sectors of two-dimensional Carrollian CFTs
Journal of High Energy PhysicsWe revisit modular invariance in two-dimensional Carrollian conformal field theories from a geometric perspective. Focusing on the characters of the induced and highest-weight representations of the theory, we show that there are regions of parameter ...
Ankit Aggarwal +5 more
doaj +1 more source
Circuit complexity of knot states in Chern-Simons theory
Journal of High Energy Physics, 2019 We compute an upper bound on the circuit complexity of quantum states in 3d Chern-Simons theory corresponding to certain classes of knots. Specifically, we deal with states in the torus Hilbert space of Chern-Simons that are the knot complements on the 3-
Giancarlo Camilo +3 more
doaj +1 more source