Results 61 to 70 of about 15,050 (265)
Molecular Oncology, EarlyView.This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad +17 more
wiley +1 more source
Flavor structures of quarks and leptons from flipped SU(5) GUT with A 4 modular flavor symmetry
Journal of High Energy Physics, 2023 We propose to generate the flavor structures of the Standard Model plus neutrinos from flipped SU(5) GUT with A 4 modular flavor symmetry. Possible way to assign different moduli values for quarks and leptons in modular GUT scheme is discussed.
Xiao Kang Du, Fei Wang
doaj +1 more source
Representations of modular skew group algebras [PDF]
Transactions of the American Mathematical Society, 2015 In this paper we study representations of skew group algebras $ G$, where $ $ is a connected, basic, finite-dimensional algebra (or a locally finite graded algebra) over an algebraically closed field $k$ with characteristic $p \geqslant 0$, and $G$ is an arbitrary finite group each element of which acts as an algebra automorphism on $ $.
openaire +3 more sources
Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting
Molecular Oncology, EarlyView.CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia +9 more
wiley +1 more source
Systematic Analysis of Speech Transcription Modeling for Reliable Assessment of Depression Severity
Sakarya University Journal of Computer and Information SciencesFor depression severity assessment, we systematically analyze a modular deep learning pipeline that uses speech transcriptions as input for depression severity prediction.
Hamdi Dibeklioğlu +1 more
doaj +1 more source
Molecular Oncology, EarlyView.Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra +10 more
wiley +1 more source
Molecular Oncology, EarlyView.Liquid biopsy enables minimally invasive, real‐time molecular profiling through analysis of circulating biomarkers in biological fluids. This Perspective highlights the importance of training pathologists through integrative educational programs, such as the European Masters in Molecular Pathology, to ensure effective and equitable implementation of ...
Marius Ilié +13 more
wiley +1 more source
Molecular Oncology, EarlyView.Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice +16 more
wiley +1 more source
Modular principal series representations [PDF]
International Mathematics Research Notices, 2006 16 pages; the revised version contains additional references; the second revision corrects minor errors; to appear in IMRN (2006)
openaire +2 more sources
Molecular Oncology, EarlyView.The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola +12 more
wiley +1 more source