Results 31 to 40 of about 160,015 (295)
Real‐time assay of ribonucleotide reductase activity with a fluorescent RNA aptamer
FEBS Letters, EarlyView.Ribonucleotide reductases (RNR) synthesize DNA building blocks de novo, making them crucial in DNA replication and drug targeting. FLARE introduces the first single‐tube real‐time coupled RNR assay, which enables isothermal tracking of RNR activity at nanomolar enzyme levels and allows the reconstruction of allosteric regulatory patterns and rapid ...
Jacopo De Capitani +4 more
wiley +1 more source
An a posteriori measure of network modularity [v3; ref status: indexed, http://f1000r.es/2ju]
F1000Research, 2013 Measuring the modularity of networks, and how it deviates from random expectations, important to understand their structure and emerging properties. Several measures exist to assess modularity, which when applied to the same network, can return both ...
Timothée Poisot
doaj +1 more source
Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing
FEBS Letters, EarlyView.Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley +1 more source
Acta Societatis Botanicorum Poloniae, 2014 Network modularity is a well-studied large-scale connectivity pattern in networks. The detection of modules in real networks constitutes a crucial step towards a description of the network building blocks and their evolutionary dynamics.
Thorsten Thiergart +4 more
doaj +1 more source
Frontiers in Ecology and Evolution, 2020 Developmental modularity has long been viewed as a hierarchical organization that facilitates evolution through modification or reuse of preexisting modules.
James J. Lewis, Steven M. Van Belleghem
doaj +1 more source
Function‐driven design of a surrogate interleukin‐2 receptor ligand
FEBS Letters, EarlyView.Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang +9 more
wiley +1 more source
A phase-shifting anterior-posterior network organizes global phase relations.
PLoS ONEPrior research has identified a variety of task-dependent networks that form through inter-regional phase-locking of oscillatory activity that are neural correlates of specific behaviors.
Melisa Menceloglu +2 more
doaj +1 more source
Encyclopedia, 2021 The term “Nanotechnology” describes a large field of scientific and technical activities dealing with objects and technical components with small dimensions.
Johann Michael Köhler
doaj +1 more source
, 2011 We introduce Modular Markovian Logic (MML) for compositional continuous-time and continuous-space Markov processes. MML combines operators specific to stochastic logics with operators reflecting the modular structure of the models, similar to those used by spatial and separation logics.
Cardelli L., Larsen K.G., Mardare R.
openaire +3 more sources
FEBS Letters, EarlyView.We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee +3 more
wiley +1 more source