Results 41 to 50 of about 160,015 (295)

Spectral characterization of hierarchical network modularity and limits of modularity detection.

PLoS ONE, 2013
Many real world networks are reported to have hierarchically modular organization. However, there exists no algorithm-independent metric to characterize hierarchical modularity in a complex system.
Somwrita Sarkar, James A Henderson, Peter A Robinson   +2 more
doaj   +1 more source

Bottlenecks, Modularity, and the Neural Control of Behavior

Frontiers in Behavioral Neuroscience, 2022
In almost all animals, the transfer of information from the brain to the motor circuitry is facilitated by a relatively small number of neurons, leading to a constraint on the amount of information that can be transmitted.
Anjalika Nande, Anjalika Nande, Veronika Dubinkina, Veronika Dubinkina, Riccardo Ravasio, Riccardo Ravasio, Grace H. Zhang, Gordon J. Berman   +7 more
doaj   +1 more source

Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting

Molecular Oncology, EarlyView.
CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia, Noelia Moares, Wenjie Yi‐He, Rosa Luna‐Espejo, Ricardo Fernandez‐Cisnal, Javier Ocaña‐Cuesta, Juan P. Muñoz‐Miranda, Antonio Gabucio, Cecilia M. Fernandez‐Ponce, Francisco Garcia‐Cozar   +9 more
wiley   +1 more source

PREVENTIVE MAINTENANCE SYSTEM DENGAN MODULARITY DESIGN SEBAGAI SOLUSI PENURUNAN BIAYA MAINTAINANCE (Studi Kasus di Perusahaan Tepung Ikan)

Jurnal Teknik Industri, 2005
Mofularity design has been applied in many European countries, especially in industrial assembling and manufacturing. Modularity design cause manufacture process and assembly process easier and cheaper.
Julianingsih Julianingsih, Willyanto Anggono   +1 more
doaj  

Revisiting the modularity of modular polyketide synthases [PDF]

Current Opinion in Chemical Biology, 2009
Modularity is a highly sought after feature in engineering design. A modular catalyst is a multi-component system whose parts can be predictably interchanged for functional flexibility and variety. Nearly two decades after the discovery of the first modular polyketide synthase (PKS), we critically assess PKS modularity in the face of a growing body of ...
Chaitan, Khosla, Shiven, Kapur, David E, Cane   +2 more
openaire   +2 more sources

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Modularity and anti-modularity in networks with arbitrary degree distribution

Biology Direct, 2010
Background Much work in systems biology, but also in the analysis of social network and communication and transport infrastructure, involves an in-depth analysis of local and global properties of those networks, and how these properties relate to the ...
Adami Christoph, Hintze Arend
doaj   +1 more source

Actin dynamics controlled by IqgC, a RasGAP at the crossroads between the IQGAP and fungal GAP1 families

FEBS Open Bio, EarlyView.
IqgC is a RasGAP from Dictyostelium discoideum. IqgC binds RasG via its RasGAP domain and deactivates it on macroendocytic cups, thereby suppressing the uptake of fluid and particles. IqgC has a positive effect on cell‐substratum adhesion, and its RGCt domain is required for recruitment to ventral foci.
Vedrana Filić, Darija Putar, Lucija Mijanović, Igor Weber   +3 more
wiley   +1 more source

Rethinking modularity as contextual design thinking

ARSNET
This study aims to reflect and expand the notion of modularity in architectural design methods. The discussion about modular architecture is certainly familiar across architectural discourse; where its universality has been repeatedly challenged by the ...
Bramasta Putra Redyantanu, Rony Gunawan Sunaryo   +1 more
doaj   +1 more source

The taming of the neural crest: a developmental perspective on the origins of morphological covariation in domesticated mammals [PDF]

Royal Society Open Science, 2016
Studies on domestication are blooming, but the developmental bases for the generation of domestication traits and breed diversity remain largely unexplored.
Marcelo R. Sánchez-Villagra, Madeleine Geiger, Richard A. Schneider   +2 more
doaj   +1 more source