Results 71 to 80 of about 764,488 (297)

Inventory of personal factors influencing conditioned pain modulation in healthy people: a systematic literature review [PDF]

, 2015
Background: Conditioned pain modulation (CPM) is believed to play an important role in the development and exacerbation of chronic pain, because dysfunction of CPM is associated with a shift in balance between pain facilitation and pain inhibition.
Calders, Patrick, Crombez, Geert, Goubert, Dorien, Goudman, Lisa, Hermans, Linda, Meeus, Mira, Van Oosterwijck, Jessica   +6 more
core   +1 more source

Switching Modulation Strategies for Multilevel Inverter

ELEKTRIKA- Journal of Electrical Engineering, 2021
There is always a need to create efficient and optimized converters to deliver the best possible results to achieve a better THD profile in the waveform output. One way is by controlling the switching of the power switches of the converters using appropriate modulation schemes.
Jahanzeb, Jahanzeb, Md. Ayob, Shahrin, Khan, Saifullah, Daud, Mohd. Zaki, Ayop, Razman   +4 more
openaire   +2 more sources

Structural insights into lacto‐N‐biose I recognition by a family 32 carbohydrate‐binding module from Bifidobacterium bifidum

FEBS Letters, EarlyView.
Bifidobacterium bifidum establishes symbiosis with infants by metabolizing lacto‐N‐biose I (LNB) from human milk oligosaccharides (HMOs). The extracellular multidomain enzyme LnbB drives this process, releasing LNB via its catalytic glycoside hydrolase family 20 (GH20) lacto‐N‐biosidase domain.
Xinzhe Zhang, Naoki Sunagawa, Toma Kashima, Kiyohiko Igarashi, Akimasa Miyanaga, Shinya Fushinobu   +5 more
wiley   +1 more source

Drug Design Strategies for GPCR Allosteric Modulators [PDF]

, 2012
Abstract Terms such as “nondruggable GPCRs” describe a unique group of GPCRs having strong biological hypothesis validation, but for which medicinal chemistry efforts based on orthosteric ligands have failed to produce marketed drugs (or even clinical development candidates).
P Jeffrey, Conn, Scott D, Kuduk, Darío, Doller   +2 more
openaire   +2 more sources

Targeted Strategies to Modulate Stem‐Cell‐Relevant Pathways [PDF]

Stem Cells International, 2016
Modulation of stem cell behavior is of significant interest to the biomedical community and could lead to novel therapeutic advances in treating disease. Achieving this goal requires specific strategies that manipulate the pathways regulating stem cell plasticity and behavior.
Jonathan W. Lowery, James A. Ankrum, Shoichiro Kokabu, Renjing Liu   +3 more
openaire   +3 more sources

The role and implications of mammalian cellular circadian entrainment

FEBS Letters, EarlyView.
At their most fundamental level, mammalian circadian rhythms occur inside every individual cell. To tell the correct time, cells must align (or ‘entrain’) their circadian rhythm to the external environment. In this review, we highlight how cells entrain to the major circadian cues of light, feeding and temperature, and the implications this has for our
Priya Crosby
wiley   +1 more source

The Harmonic Characteristic of the Advanced Synchronous SVPWM Overmodulation Strategy

IEEE Access, 2019
The speed range of the rail transit traction system is very wide and mostly uses the hybrid pulse width modulation. The traditional hybrid pulse width modulation requires different types of modulation strategies to cooperate in switching, which ...
Jie Chen, Ruizheng Ni, Ting Li, Ruichang Qiu, Zhigang Liu   +4 more
doaj   +1 more source

Interplay between circadian and other transcription factors—Implications for cycling transcriptome reprogramming

FEBS Letters, EarlyView.
This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley   +1 more source

A Novel High Power Factor and Soft Switching SAB-SWISS Rectifier With High-Low-High-Low Modulation and Hybrid Frequency Control

IEEE Access
A novel SWISS rectifier based on single active bridge converter (SAB-SR) is proposed. The high-low-high-low (HLHL) voltage waveform modulation to realize soft-switching for the power switches and the hybrid frequency control scheme to achieve high power ...
Bo Zeng, Ziwen Yang, Shi Yan, Lingjuan Tan, Shaojun Xie   +4 more
doaj   +1 more source

Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing

FEBS Letters, EarlyView.
Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley   +1 more source