Results 71 to 80 of about 766,195 (336)
Supporting the identification of novel fragment-based positive allosteric modulators using a supervised molecular dynamics approach: A retrospective analysis considering the human A2A adenosine receptor as a key example [PDF]
, 2017 Structure-driven fragment-based (SDFB) approaches have provided efficient methods for the identification of novel drug candidates. This strategy has been largely applied in discovering several pharmacological ligand classes, including enzyme inhibitors ...
Deganutti, Giuseppe, Moro, Stefano
core +1 more source
Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?
FEBS Letters, EarlyView.This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes +3 more
wiley +1 more source
On the modulation of TRPM channels: Current perspectives and anticancer therapeutic implications
Frontiers in Oncology, 2023 The transient melastatin receptor potential (TRPM) ion channel subfamily functions as cellular sensors and transducers of critical biological signal pathways by regulating ion homeostasis. Some members of TRPM have been cloned from cancerous tissues, and
Tania Ciaglia +4 more
doaj +1 more source
Glasgow Mathematical Journal, 2006 Let R be a ring. An R-module M is called a (weak) duo module provided every (direct summand) submodule of M is fully invariant. It is proved that if R is a commutative domain with field of fractions K then a torsion-free uniform R-module is a duo module if and only if every element k in K such that kM is contained in M belongs to R.
Ozcan, A.C., Harmanci, A., Smith, P.F.
openaire +2 more sources
Solving Problems on Graphs of High Rank-Width
, 2015 A modulator of a graph G to a specified graph class H is a set of vertices whose deletion puts G into H. The cardinality of a modulator to various tractable graph classes has long been used as a structural parameter which can be exploited to obtain FPT ...
A Brandstädt +18 more
core +1 more source
The role and implications of mammalian cellular circadian entrainment
FEBS Letters, EarlyView.At their most fundamental level, mammalian circadian rhythms occur inside every individual cell. To tell the correct time, cells must align (or ‘entrain’) their circadian rhythm to the external environment. In this review, we highlight how cells entrain to the major circadian cues of light, feeding and temperature, and the implications this has for our
Priya Crosby
wiley +1 more source
Probing Mechanisms and Therapeutic Potential of γ-Secretase in Alzheimer’s Disease
Molecules, 2021 The membrane-embedded γ-secretase complex carries out hydrolysis within the lipid bilayer in proteolyzing nearly 150 different membrane protein substrates.
Michael S. Wolfe
doaj +1 more source
International Mathematics Research Notices, 2015 We introduce the new concept of silting modules. These modules generalise tilting modules over an arbitrary ring, as well as support $ $-tilting modules over a finite dimensional algebra recently introduced by Adachi, Iyama and Reiten. We show that silting modules generate torsion classes that provide left approximations, and that every partial ...
Hügel, Lidia Angeleri +2 more
openaire +2 more sources
Quantum Modelling of Electro-Optic Modulators
, 2011 Many components that are employed in quantum information and communication systems are well known photonic devices encountered in standard optical fiber communication systems, such as optical beamsplitters, waveguide couplers and junctions, electro-optic
Capmany, Jose +1 more
core +1 more source
A rigorous approach to the robust design of continuous-time ΣΔ modulators [PDF]
, 2011 In this paper we present a framework for robust design of continuous-time Sigma Delta modulators. The approach allows to find a modulator which maintains its performance ( stability, guaranteed peak SNR, ...) over all the foreseen parasitic effects ...
De Vuyst, Bart +2 more
core +2 more sources