Results 111 to 120 of about 1,019,672 (318)

Module extraction via query inseparability in OWL 2 QL [PDF]

open access: yes, 2011
We show that deciding conjunctive query inseparability for OWL 2 QL ontologies is PSpace-hard and in ExpTime. We give polynomial-time (incomplete) algorithms and demonstrate by experiments that they can be used for practical module ...
Schneider, T.   +5 more
core  

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

open access: yesFEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi   +6 more
wiley   +1 more source

Logotipo del Open Peer Review Module [PDF]

open access: yes, 2016
https://github.com/arvoConsultores/Open-Peer-Review-Module/wikihttp://www.openscholar.org.uk/developing-the-first-open-peer-review-module-for-institutional-repositories/The Open Peer Review Module Consortium include: Open Scholar, Arvo Consultores (a ...
Oficina Técnica de DIGITAL.CSIC   +2 more
core   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

open access: yesFEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj   +3 more
wiley   +1 more source

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

open access: yesFEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang   +4 more
wiley   +1 more source

Characterization of a wheat stable QTL for spike length and its genetic effects on yield-related traits

open access: yesBMC Plant Biology
Spike length (SL) is one of the most important agronomic traits affecting yield potential and stability in wheat. In this study, a major stable quantitative trait locus (QTL) for SL, i.e., qSl-2B, was detected in multiple environments in a recombinant ...
Hongke Ding   +14 more
doaj   +1 more source

AscF in the mycobacterial CIII–CIV supercomplex lacks metal and nucleotide binding but links malate oxidation to respiration

open access: yesFEBS Letters, EarlyView.
The mycobacterial CIII‐CIV respiratory supercomplex is an obligate assembly, encompassing several subunits of unknown functions. We have characterized the intracellular subunit AscF, and show that it is unlikely to be a sensor for metals or nucleotides, but is required for growth on nonfermentable energy sources, and likely works as an adapter for ...
Eni Rile   +8 more
wiley   +1 more source

CESNET/proxystatistics-simplesamlphp-module: v1.2.0 [PDF]

open access: yes, 2018
<p>[Added]</p> <ul> <li>Classes SimpleSAML_Logger and SimpleSAML_Module renamed to SimpleSAML\Logger and SimpleSAML\Module</li> <li>Dictionary</li> <li>Czech translation</li> </ul> <p> ...
BaranekD   +2 more
core   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

open access: yesMolecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce   +11 more
wiley   +1 more source

supportDM module 4: what data to keep and why [PDF]

open access: yes, 2014
Fourth module on selection and appraisal of data for long term curation, part of the supportDM course aimed at those in RDM support roles. Suitable for staff in library, IT and research office settings.
Stephen Grace
core  

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