Results 101 to 110 of about 2,084 (272)

Module des diff{\'e}rentielles

, 2023
For any object x in a category C it is possible to define the category of Beck modules over x as the category Ab(C/x) of abelian group objects in the category C/x.
Vaquié, Michel
core  

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Curve singularities with one Puiseux pair and value sets of modules over their local rings

In this paper we characterize the value set \Delta of the R-modules of the form R+zR for the local ring R associated to a germ \xi of an irreducible plane curve singularity with one Puiseux pair.
Almirón, Patricio, Alberich-Carramiñana, Maria, Moyano-Fernández, Julio-José   +2 more
core   +1 more source

Patient therapy outcome modeling in cancer organoids is improved by cancer‐associated fibroblasts and organoid assembly convolution

Molecular Oncology, EarlyView.
Patient‐derived organoids (PDOs) from pancreatic, colorectal, and gastric cancers were used to evaluate standard and experimental therapies. Incorporating cancer‐associated fibroblasts (CAFs) into organoid cultures improved patient therapy outcome prediction.
Marcin Grochowski, Liudmyla Dolinchuk, Michał Jerzak, Albert Gandurski, Tomasz Grochowski, Weronika Wojtyś, Maciej Zadrożny, Wojciech Kaźmierczak, Małgorzata Lenarcik, Marta Matejak‐Górska, Radosław Samsel, Tomasz Olesiński, Dawid Walerych   +12 more
wiley   +1 more source

Symmetric derivations of universal modules.

, 2016
TEZ11042Tez (Doktora) -- Çukurova Üniversitesi, Adana, 2016.Kaynakça (s. 109-110) var.vi, 111 s. ; 29 cm.k karakteristiği sıfır olan bir cisim, R bir k ??cebir, ????n ??R ; R nin n ??inci dereceden evrensel türev modülü (Kähler modülü), : ????n n d R?????
Merkepçi, Hamiyet
core  

Differential theory of zero-dimensional schemes

To study a 0-dimensional scheme |X in |P^n over a perfect field K, we use the module of Kähler differentials (Omega)(^1)(_{R/K}) of its homogeneous coordinate ring R and its exterior powers, the higher modules of Kähler differentials (Omega)(^m)(_{R/K}).
Kreuzer, Martin, Linh, Tran N. K., Long, Le N.   +2 more
core   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Anneaux de valuation discrète et modules des différentielles

, 1998
RésuméThe module of Kähler differentials of a commutativeG-algebraXis essentially described by two cardinals and two integers whenXis a valuation ring and when the residue extension is good enough.
André, Michel
core   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

Purity of Branch and Critical locus

, 2013
To a dominant morphism $X/S \to Y/S$ of N\oe therian integral $S$-schemes one has the inclusion $C_{X/Y}\subset B_{X/Y}$ of the critical locus in the branch locus of $X/Y$.
Källström, Rolf,
core   +1 more source