Results 81 to 90 of about 2,084 (272)

DIFFERENTIAL MODULES WITH COMPLETE INTERSECTION HOMOLOGY

Journal of Commutative Algebra
Differential modules are natural generalizations of complexes. In this paper, we study differential modules with complete intersection homology, comparing and contrasting the theory of these differential modules with that of the Koszul complex. We construct a Koszul differential module that directly generalizes the classical Koszul complex and ...
Banks, Maya, VandeBogert, Keller
openaire   +3 more sources

Connected components of the strata of the moduli space of meromorphic differentials

, 2015
International audienceIn this paper, we study the translation surfaces corresponding to meromorphic differentials on compact Riemann surfaces. We compute the number of connected components of the corresponding strata of the moduli space.
Boissy, Corentin, Corentin Boissy
core  

Adaptor protein CIN85 potentiates the motility of osteosarcoma cells via the Akt/mTOR and MMP2‐COL3A1 axis

Molecular Oncology, EarlyView.
CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak, Iva Staniczková Zambo, Matěj Přikryl, Peter Múdry, Danica Zapletalová, Jarmila Navrátilová, Jiří Navrátil, Jan Šmarda, Liudmyla Drobot, Petr Beneš, Lucia Knopfová   +10 more
wiley   +1 more source

Modules of Finite Projective Dimension and Singularities

In the first part of this thesis, we study liftings of modules of finite projective dimension. We introduce a notion of “Serre liftable” modules and deduce applications to multiplicity conjectures in local algebra.
KC, Nawaj
core  

Longitudinal circulating tumor DNA profiling in patients with advanced endometrial cancer using an off‐the‐shelf targeted NGS panel

Molecular Oncology, EarlyView.
Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena, Karin Teien Lande, Eva Diaz, Ana Vilar, Juan Cueva, Efigenia Arias, Victoria Sampayo, Alicia Abalo, Nerea González, Eva Colás, Antonio Gil‐Moreno, Miguel Abal, Gema Moreno‐Bueno, Therese Sørlie, Kristina Lindemann, Laura Muinelo‐Romay   +15 more
wiley   +1 more source

On modules whose dual is of finite Gorenstein dimension: The $k$-torsion, homological criteria, and applications in modules of differentials of order $n$

In this paper, we aim to obtain some results under the condition that the dual of a module has finite Gorenstein dimension. In this direction we derive results involving vanishing of Ext as well as the freeness or totally reflexivity of modules.
Mendoza-Rubio, Victor D., Jorge-Pérez, Victor H.   +1 more
core  

Gauss-Manin connection via Witt-differentials

, 2005
Langer A, Zink T. Gauss-Manin connection via Witt-differentials. Nagoya Mathematical Journal. 2005;179:1-16.Let X/R be a smooth scheme over a ring R. Consider the category of locally free crystals of finite rank on the situs Crys(X/W-t(R)).
Langer, Andreas, Zink, Thomas
core  

Interaction of HS1BP3 with cortactin modulates TKS5 localisation, cell secretion and cancer malignancy

Molecular Oncology, EarlyView.
Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen, Kristiane Søreng, Chiara Veroni, Laura Trachsel‐Moncho, Nagham Asp, Robin Gaupset, Lars Gustav Lyckander, Helene Knævelsrud, Lars Eftang, Anne Simonsen   +9 more
wiley   +1 more source

Curved BGG Correspondence

, 2021
The Bernstein-Gel’fand-Gel’fand Correspondence is an equivalence between the bounded derived categories of finitely generated graded modules over an exterior algebra and that of a symmetric algebra.
Martin, A. Amadeus
core  

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source