Results 71 to 80 of about 2,084 (272)
A brief note on the existence of connections and covariant derivatives on modules
, 2017 In this note we make a review of the concepts of connection and covariant derivative on modules, in a purely algebraic context. Throughout the text, we consider algebras over an algebraically closed field of characteristic 0 and module will always mean ...
Rojas, Jacqueline F., Mendoza, Ramón
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Molecular Oncology, EarlyView.Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau +36 more
wiley +1 more source
Intersection theory of spaces of holomorphic and meromorphic differentials
, 2017 Nous construisons l'espace des différentielles stables : un espace des modules de différentielles méromorphes avec des pôles d'ordres fixés. Cet espace est un cône au dessus de l'espace Mg,n des courbes stables. Si l'ensemble de poles est vide, il s'agit
Sauvaget, Adrien
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Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer
Molecular Oncology, EarlyView.COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann +61 more
wiley +1 more source
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Molecular Oncology, EarlyView.Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch +13 more
wiley +1 more source
Integrally closed modules and their divisors
, 2008 There is a beautiful theory of integral closure of ideals in regular local rings of dimension two, due to Zariski, several aspects of which were later extended to modules. Our goal is to study integral closures of modules over normal domains by attaching
Wolmer V. Vasconcelos +2 more
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CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3
Molecular Oncology, EarlyView.PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh +12 more
wiley +1 more source
Siegel-Veech constants for strata of moduli spaces of quadratic differentials
, 2015 46 pages, 18 figuresInternational audienceWe present an explicit formula relating volumes of strata of meromorphicquadratic differentials with at most simple poles on Riemann surfacesand counting functions of the number of flat cylinders filled by ...
Goujard, Elise
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Molecular Oncology, EarlyView.EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain +10 more
wiley +1 more source