Results 31 to 40 of about 938,110 (195)

TH17–Associated Polyamine Metabolism‐Guided Nanozyme Promotes Alveolar Bone Repair in Periodontitis

Advanced Science, EarlyView.
A pronounced TH17‐skewed immune response is identified in experimental periodontitis, and enrichment of the polyamine pathway is observed during TH17 differentiation, suggesting its potential as an immunometabolic target. Inspired by these findings, DFMO@Ui‐Mn is developed as a therapeutic platform combining cascade ROS scavenging with immunometabolic ...
Cheng Zhu, Tiancheng Li, Yu Jin, Yixin Li, Qicheng Liu, Runzhe Fang, Luyao Qu, Xinyue Tang, Ruomei Li, Xiaoyue Zhao, Jin Hao, Bing Fang, Lunguo Xia   +12 more
wiley   +1 more source

Unravelling the functional biomechanics of dental features and tooth wear [PDF]

, 2013
Most of the morphological features recognized in hominin teeth, particularly the topography of the occlusal surface, are generally interpreted as an evolutionary functional adaptation for mechanical food processing.
Kullmer, Ottmar, Nguyen, H., Stefano Benazzi (227062), Stefano Benazzi, Hublin, Jean-Jacques, Kullmer, O., Nguyen, Huynh Nhu, Huynh Nhu Nguyen, Jean-Jacques Hublin, Hublin, J. ; https://orcid.org/, Jean-Jacques Hublin (406373), Ottmar Kullmer (164077), Benazzi, S. ; https://orcid.org/, Benazzi, Stefano, Huynh Nhu Nguyen (406370), Ottmar Kullmer, Jean Jacques Hublin, Nguyen Huynh Nhu, Hublin Jean-Jacques, Benazzi Stefano, Kullmer Ottmar   +20 more
core   +1 more source

Expanding the Phenotypic Spectrum of TXNDC15‐Related Ciliopathies to Include Joubert Syndrome

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT Biallelic loss‐of‐function variants in TXNDC15 are a known cause of the perinatally lethal ciliopathy Meckel syndrome (MKS). TXNDC15 encodes an endoplasmic reticulum (ER)‐resident thioredoxin‐domain protein required for ciliary transition zone integrity.
Zachary T. Sentell, Robert Geraghty, Juliana E. Arcila‐Galvis, Praveen Dhondurao‐Sudhindar, Sergio Foullerat Cañada, Fulvio D'Abrusco, Bosanka Jocic‐Jakubi, Miguel Barroso‐Gil, Valentina Serpieri, Thomas M. Kitzler, Kate E. Chandler, Eleanor G. Seaby, Gabrielle Wheway, Jennifer C. Dempsey, Dan Doherty, Enza M. Valente, John A. Sayer   +16 more
wiley   +1 more source

Autotransplantation of mature impacted tooth to a fresh molar socket using a 3D replica and guided bone regeneration: two years retrospective case series

BMC Oral Health, 2019
Background The aim of this study was to evaluate the clinical outcome of autotransplantation of mature third molars to fresh molar extraction sockets using 3D replicas. Methods Ten patients underwent teeth autotransplantation with or without GBR.
Ye Wu, Jiaming Chen, Fuping Xie, Huanhuan Liu, Gang Niu, Lin Zhou   +5 more
doaj   +1 more source

Novel CPLANE1 c.8948dupT (p.P2984Tfs*7) variant in a child patient with Joubert syndrome

Open Life Sciences, 2023
Joubert syndrome (JBTS) is a class of heterogeneous ciliopathy genetically associated with CPLANE1 mutations. The characteristics of clinical phenotypes and CPLANE1 variants were analyzed in a 2-month-old patient.
Wang Huiping, Nie Wensha, Wang Chunxia, Wang Zuohua, Zheng Yuxia   +4 more
doaj   +1 more source

TTC21B: From Modifier to Causative Gene in Joubert Syndrome

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT Biallelic pathogenic variants in TTC21B, encoding the retrograde intraflagellar transport protein IFT139, are a known cause of renal and skeletal ciliopathies. Single heterozygous variants in this gene were found to be enriched in a cohort of patients with various ciliopathy phenotypes, including three individuals with Joubert syndrome (JS), a
Valentina Serpieri, Fulvio D'Abrusco, Anna Pichiecchio, Thouraya Ben Younes, Ichraf Kraoua, Enza Maria Valente   +5 more
wiley   +1 more source

Joubert syndrome: a case report

Bulletin of Faculty of Physical Therapy, 2021
Background Joubert syndrome (JS) is a rare autosomal recessive genetic heterogeneously inherited disorder characterized by neurological features that include hypotonia, ataxia, developmental delay, intellectual disability, abnormal eye movements, and ...
Sarfaraz Alam, Fatema Khatoon, Nazim Khan   +2 more
doaj   +1 more source

Clinical and genetic characteristics of 36 children with Joubert syndrome

Frontiers in Pediatrics, 2023
Background and aimsJoubert syndrome (JBTS, OMIM # 213300) is a group of ciliopathies characterized by mid-hindbrain malformation, developmental delay, hypotonia, oculomotor apraxia, and breathing abnormalities.
Yan Dong, Yan Dong, Ke Zhang, Ke Zhang, He Yao, He Yao, Tianming Jia, Jun Wang, Dengna Zhu, Falin Xu, Meiying Cheng, Shichao Zhao, Xiaoyi Shi   +12 more
doaj   +1 more source

Molar macrowear reveals Neanderthal eco-geographic dietary variation [PDF]

, 2011
Neanderthal diets are reported to be based mainly on the consumption of large and medium sized herbivores, while the exploitation of other food types including plants has also been demonstrated.
Kullmer, Ottmar, Luca Fiorenza, Stefano Benazzi, Friedemann Schrenk, Bromage, Timothy G., Tausch, Jeremy, Timothy G Bromage, Bromage, Timothy, Jeremy Tausch, Timothy G. Bromage, Fiorenza, Luca, Benazzi, Stefano, Schrenk, Friedemann, Ottmar Kullmer, Benazzi Stefano, Bromage Timothy G., Tausch Jeremy, Fiorenza Luca, Schrenk Friedemann, Kullmer Ottmar   +19 more
core   +1 more source

An osteohistological analysis of Triceratops (Ornithischia: Ceratopsidae) cranial ornamentation

The Anatomical Record, EarlyView.
Abstract Ceratopsids are among the most distinctive and well known extinct Cretaceous vertebrates, yet many details regarding the growth and composition of their cranial features are still not fully anatomically described or understood. In particular, striking cranial adornments such as the postorbital horns and parietal‐squamosal frill of Triceratops ...
Kyle D. Obuszewski, N. Adam Smith, Guinevere Rose Brown   +2 more
wiley   +1 more source