Results 51 to 60 of about 151,455 (297)

CAE/CAD in injection molding, blow molding, and foam molding—the shortest way to mold design

Advances in Polymer Technology, 1985
AbstractOne of the basic prerequisites for rational and high quality production of plastic parts is a tool layout tailored to the production process. To date, both design and construction have generally been based on values acquired by experience. This first, necessitates highly qualified personnel and second, involves what is frequently time consuming
O. Kretzschmar, Th. Schacht, Th. Schmidt, K. Esser, U. Maier   +4 more
openaire   +2 more sources

Making tau amyloid models in vitro: a crucial and underestimated challenge

FEBS Letters, EarlyView.
This review highlights the challenges of producing in vitro amyloid assemblies of the tau protein. We review how accurately the existing protocols mimic tau deposits found in the brain of patients affected with tauopathies. We discuss the important properties that should be considered when forming amyloids and the benchmarks that should be used to ...
Julien Broc, Clara Piersson, Yann Fichou
wiley   +1 more source

Research on an Intelligent Design Method for the Geometric Structure of Three-Layer Hollow Fan Blades

Aerospace
The geometric structure design of three-layer hollow fan blades is extremely complex, which is not only directly related to the blade quality and manufacturing cost but also has a significant impact on engine performance.
Jialin Lei, Jiale Chao, Chuipin Kong, Xionghui Zhou   +3 more
doaj   +1 more source

The cytoskeletal control of B cell receptor and integrin signaling in normal B cells and chronic lymphocytic leukemia

FEBS Letters, EarlyView.
In lymphoid organs, antigen recognition and B cell receptor signaling rely on integrins and the cytoskeleton. Integrins act as mechanoreceptors, couple B cell receptor activation to cytoskeletal remodeling, and support immune synapse formation as well as antigen extraction.
Abhishek Pethe, Tanja Nicole Hartmann
wiley   +1 more source

Social context prevents heat hormetic effects against mutagens during fish development

FEBS Letters, EarlyView.
This study shows that sublethal heat stress protects fish embryos against ultraviolet radiation, a concept known as ‘hormesis’. However, chemical stress transmission between fish embryos negates this protective effect. By providing evidence for the mechanistic molecular basis of heat stress hormesis and interindividual stress communication, this study ...
Lauric Feugere, Claudio Silva De Freitas, Adam Bates, Kenneth B. Storey, Pedro Beltran‐Alvarez, Katharina C. Wollenberg Valero   +5 more
wiley   +1 more source

Fungal Endophthalmitis Associated with Compounded Products

Emerging Infectious Diseases, 2014
Fungal endophthalmitis is a rare but serious infection. In March 2012, several cases of probable and laboratory-confirmed fungal endophthalmitis occurring after invasive ocular procedures were reported nationwide.
Christina A. Mikosz, Rachel M. Smith, Moon Kim, Clara Tyson, Ellen H. Lee, Eleanor Adams, Susanne Straif-Bourgeois, Rick Sowadsky, Shannon Arroyo, Yoran Grant-Greene, Julie Duran, Yvonne Vasquez, Byron F. Robinson, Julie R. Harris, Shawn R. Lockhart, Thomas J. Török, Laurene Mascola, Benjamin J. Park   +17 more
doaj   +1 more source

Process Diagnosis of Liquid Steel Flow in a Slab Mold Operated with a Slide Valve

Crystals, 2020
Slab molds receive liquid steel from the tundish through bifurcated submerged entry nozzles (SEN) using a slide valve as throughput control. Due to the off-centering position of the three plates’ orifices that conform to the valve to control the steel ...
Jafeth Rodríguez-Ávila, Carlos Rodrigo Muñiz-Valdés, Rodolfo Morales-Dávila, Alfonso Nàjera-Bastida   +3 more
doaj   +1 more source

Interaction vesicles as emerging mediators of host‐pathogen molecular crosstalk and their implications for infection dynamics

FEBS Letters, EarlyView.
Interaction extracellular vesicles (iEVs) are hybrid vesicles formed through host‐pathogen communication. They facilitate immune evasion, transfer pathogens' molecules, increase host cell uptake, and enhance virulence. This Perspective article illustrates the multifunctional roles of iEVs and highlights their emerging relevance in infection dynamics ...
Bruna Sabatke, Izadora Volpato Rossi, Marcel I. Ramirez   +2 more
wiley   +1 more source

Decoding the dual role of autophagy in cancer through transcriptional and epigenetic regulation

FEBS Letters, EarlyView.
Transcriptional and epigenetic regulation controls autophagy, which exerts context‐dependent effects on cancer: Autophagy suppresses tumorigenesis by maintaining cellular homeostasis or promotes tumor progression by supporting survival under stress. In this “In a Nutshell” article, we explore the intricate mechanisms of the dual function of autophagy ...
Young Suk Yu, Ik Soo Kim, Sung Hee Baek
wiley   +1 more source

Autophagy in cancer and protein conformational disorders

FEBS Letters, EarlyView.
Autophagy plays a crucial role in numerous biological processes, including protein and organelle quality control, development, immunity, and metabolism. Hence, dysregulation or mutations in autophagy‐related genes have been implicated in a wide range of human diseases.
Sergio Attanasio
wiley   +1 more source