Results 21 to 30 of about 279,147 (262)

Human three-dimensional engineered neural tissue reveals cellular and molecular events following cytomegalovirus infection

Biomaterials, 2015
Human cytomegalovirus (HCMV) is the most common cause of congenital infection of the central nervous system (CNS). To overcome the limited access to human neural tissue and stringent species specificity of HCMV, we used engineered neural tissues to: (i) provide a technical advance to mimick features of HCMV infection in a human neural fetal tissue in ...
Cosset, Erika, Martinez, Yannick, Preynat-Seauve, Olivier, Lobrinus, Johannes-Alexander, Tapparel, Caroline, Cordey, Samuel, Peterson, Hedi, Petty Ii, Thomas John, Colaianna, Marilena, Tieng, Vannary, Tirefort, Diderik, Dinnyes, Andras, Dubois-Dauphin, Michel, Kaiser, Laurent, Krause, Karl-Heinz   +14 more
openaire   +5 more sources

CRISPR-Cas12 in immunotherapy and Beyond: Advances and challenges

Current Research in Biotechnology
CRISPR-Cas12 technology has greatly advanced gene editing, offering high efficiency and accuracy. Its main applications include gene modification, disease diagnosis, and especially the development of personalized cancer therapies.
Tahereh Zarei Taher, Mohammad Hassan Yousefi, Hamed Afkhami, Maria Kavianpour, Amir Hossein Kheirkhah   +4 more
doaj   +1 more source

Engineered mesenchymal stem cell-derived exosomes: A revolutionary approach to unlocking liver disease treatment

Biochemistry and Biophysics Reports
Exosomes, a specific type of extracellular vesicle with diameters ranging from 30 to 150 nm, play a vital role in coordinating various physiological and pathological processes through direct cell-to-cell communication.
Amir Hossein Kheirkhah, Mohsen Sheykhhasan, Faezeh Hosseinzadeh, Leyla Fath-Bayati   +3 more
doaj   +1 more source

Early Dietary Exposures Epigenetically Program Mammary Cancer Susceptibility through Igf1-Mediated Expansion of the Mammary Stem Cell Compartment

Cells, 2022
Diet is a critical environmental factor affecting breast cancer risk, and recent evidence shows that dietary exposures during early development can affect lifetime mammary cancer susceptibility.
Yuanning Zheng, Linjie Luo, Isabel U. Lambertz, Claudio J. Conti, Robin Fuchs-Young   +4 more
doaj   +1 more source

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Exploring Phage-Antibiotic Synergies in The Context of Biofilm-related Infectious Diseases

International Journal of Infectious Diseases
Introduction: Not only the emergence of resistance mechanisms towards routinely used antibiotics but also the formation of so-called biofilms, present in about 80% of clinical infections, is causing huge problems in the clinics.
Dr Steven De Soir, MSc Hortence Parée, Dr. Nur Hidayatul Nazirah Kumarudin, Dr. Jeroen Waegemans, Professor Rob Lavigne, Professor Annabel Braem, Dr. Maya Merabishvilli, Dr. Daniel De Vos, Dr. Jean-Paul Pirnay, Professor Françoise Van Bambeke   +9 more
doaj   +1 more source

Residual tail twisting in ascidian larvae is stabilized by asymmetric myofibrils that resist bilateral symmetry restoration

FEBS Letters, EarlyView.
Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure, Misaki K. Nishio, Satoru Okuda, Kohji Hotta   +3 more
wiley   +1 more source

Stem cell therapy for COVID-19 pneumonia

Molecular Biomedicine, 2022
Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) virus is a highly contagious microorganism, and despite substantial investigation, no progress has been achieved in treating post-COVID complications.
Maziar Malekzadeh Kebria, Peiman Brouki Milan, Noshad Peyravian, Jafar Kiani, Soheil Khatibi, Masoud Mozafari   +5 more
doaj   +1 more source

Septin 9 PB domains coordinate centrosome positioning and microtubule acetylation to control epithelial polarity

FEBS Letters, EarlyView.
Septin 9 polybasic domains couple phosphoinositide‐rich membrane binding to centrosome positioning, Golgi organization, and microtubule acetylation to control epithelial polarity. Their loss disrupts this axis, causing centrosome mispositioning, Golgi fragmentation, reduced microtubule acetylation, and polarity inversion via upregulation of the ...
Ting ting Cai, Mohyeddine Omrane, Nassima Benzoubir, Didier Samuel, Ama Gassama‐Diagne   +4 more
wiley   +1 more source