Results 41 to 50 of about 279,147 (262)

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

FEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas, Shahoon Khan, Abhishek Sharma, Byoungchun Lee, Savraj S. Grewal   +4 more
wiley   +1 more source

Applications of Geosynthetics in Tunnels Construction: A Sustainable Approach to Carbon Footprint Reduction

Journal of Sustainable Construction Materials and Technologies
The use of geosynthetics has transformed tunnelling practices by enhancing structural integrity, durability, and environmental sustainability. This review adopts a systematic literature review design, covering publications from 2000 to 2025 sourced from ...
Ibraheem Rais, Abdullah H. Alsabhan, Md. Rehan Sadique, Shamshad Alam   +3 more
doaj   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Beneficial Investigation of Sustainable Recycled Waste Plastic in Treating the Consolidation Behavior of Fine Soil

Journal of Sustainable Construction Materials and Technologies
Recycled waste plastic is one of the regular garbage utilized as a sustainable material in soil remediation. This study examines the efficacy of utilizing local recycled waste plastic as an ecological quantifiable along with soil containing fine ...
Aram Mohammed Raheem, Cumaraswamy Vipulanandan, Mohammed Hiwa Abdullrahman, Ali Tariq Omer   +3 more
doaj   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Produção de cartilagem articular porcina e cultura de condrócitos humanos [PDF]

, 2014
Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro Tecnológico, Programa de Pós-Graduação em Engenharia Química, Florianópolis, 2014Cartilagem articular danificada ou doente frequentemente leva à degeneração progressiva que resulta ...
Godoy, Camila Schiavinatto
core  

Experimental Study on the Behavior of High-Strength Reinforced Concrete Beams with a Longitudinal Void, with and Without Micro Steel Fibers, at Different Shear Spans

Journal of Sustainable Construction Materials and Technologies
This study examines the impact of creating a longitudinal void in high-strength reinforced concrete (RC) beams to decrease concrete volume. Testing involved three groups: solid beams (SB), beams with a 75 mm void (VB), and beams with a void incorporating
Farah M. Hussein, Saif Altai, Shatha Alasadi, Ayoob A. Ibrahim, Arshad Nadhom Shubber   +4 more
doaj   +1 more source

Smoc1 and Smoc2 regulate bone formation as downstream molecules of Runx2

Communications Biology, 2021
Takahata et al. investigate the functional role of SMOC1/2 proteins in skeletal development. They reveal a genetic pathway that includes Bmp2 and Runx2 inducing expression of the paralogous Smoc genes, which may offer novel and effective therapeutic ...
Yoshifumi Takahata, Hiromasa Hagino, Ayaka Kimura, Mitsuki Urushizaki, Sachi Kobayashi, Kanta Wakamori, Chika Fujiwara, Eriko Nakamura, Kayon Yu, Hiroshi Kiyonari, Kana Bando, Tomohiko Murakami, Toshihisa Komori, Kenji Hata, Riko Nishimura   +14 more
doaj   +1 more source

The microbiome in human skin aging

FEBS Letters, EarlyView.
Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana, Cornelia Wiegand, Omid Omrani, Mario Fabri   +3 more
wiley   +1 more source

Commentary: Could We Address the Interplay Between CD133, Wnt/β-Catenin, and TERT Signaling Pathways as a Potential Target for Glioblastoma Therapy?

Frontiers in Oncology, 2021
Christine A. Fargeas, Aurelio Lorico, Denis Corbeil   +2 more
doaj   +1 more source