Results 111 to 120 of about 14,384,780 (329)

Peptide‐based ligand antagonists block a Vibrio cholerae adhesin

FEBS Letters, EarlyView.
The structure of a peptide‐binding domain of the Vibrio cholerae adhesin FrhA was solved by X‐ray crystallography, revealing how the inhibitory peptide AGYTD binds tightly at its Ca2+‐coordinated pocket. Structure‐guided design incorporating D‐amino acids enhanced binding affinity, providing a foundation for developing anti‐adhesion therapeutics ...
Mingyu Wang, Grace Du, Charity Yongo‐Luwawa, Angelina Lu, Brett Kinrade, Kim Munro, Karl E. Klose, William D. Lubell, Peter Davies, Shuaiqi Guo   +9 more
wiley   +1 more source

Interplay between circadian and other transcription factors—Implications for cycling transcriptome reprogramming

FEBS Letters, EarlyView.
This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley   +1 more source

Genome-inspired molecular identification in organic matter via Raman spectroscopy

, 2016
Rapid, non-destructive characterization of molecular level chemistry for organic matter (OM) is experimentally challenging. Raman spectroscopy is one of the most widely used techniques for non-destructive chemical characterization, although it currently ...
Bryndzia, L. Taras, Ferralis, Nicola, Grossman, Jeffrey C., Liu, Yun   +3 more
core   +1 more source

Real‐time assay of ribonucleotide reductase activity with a fluorescent RNA aptamer

FEBS Letters, EarlyView.
Ribonucleotide reductases (RNR) synthesize DNA building blocks de novo, making them crucial in DNA replication and drug targeting. FLARE introduces the first single‐tube real‐time coupled RNR assay, which enables isothermal tracking of RNR activity at nanomolar enzyme levels and allows the reconstruction of allosteric regulatory patterns and rapid ...
Jacopo De Capitani, Noemi E. Nwosu, Viktoria Gocke, Müge Kasanmascheff, Hannes Mutschler   +4 more
wiley   +1 more source

Improving systemic therapy selection for inflammatory skin diseases: A clinical need surveyCapsule Summary

JAAD International
Background: Empirical decisions to select therapies for psoriasis (PSO) and atopic dermatitis (AD) can lead to delays in disease control and increased health care costs. However, routine molecular testing for AD and PSO are lacking. Objective: To examine
Nicholas D. Brownstone, MD, Aaron S. Farberg, MD, Graham H. Litchman, DO, MS, Ann P. Quick, PhD, Jennifer J. Siegel, PhD, Lenka V. Hurton, PhD, Matthew S. Goldberg, MD, Peter A. Lio, MD   +7 more
doaj   +1 more source

The molecular basis of lung cancer: molecular abnormalities and therapeutic implications

Respiratory Research, 2003
Lung cancer is the number one cause of cancer-related death in the western world. Its incidence is highly correlated with cigarette smoking, and about 10% of long-term smokers will eventually be diagnosed with lung cancer, underscoring the need for ...
Carbone David P, Massion Pierre P
doaj   +1 more source

Extragalactic line surveys

, 2012
40 years have passed since the first molecular detection outside our Galaxy. Since then, our knowledge on the distribution, kinematics and composition of the molecular material in the extragalactic ISM has built up significantly based not only on the ...
Costagliola, de Vicente, de Vicente, Gensheimer, Loenen, Martín, Mauersberger, Panuzzo, Sergio Martín, van der Werf, Wang   +10 more
core   +1 more source

Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing

FEBS Letters, EarlyView.
Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley   +1 more source

Microscopic and molecular detection of piroplasms among sheep in Upper Egypt

Frontiers in Veterinary Science
IntroductionBlood parasites pose a significant threat to livestock production in southern Egypt, yet there is a scarcity of information regarding their circulation and epidemiology in sheep in this region.
Ahmed Kamal Dyab, Ahmed Kamal Dyab, Sara Abdel-Aal Mohamed, Fatma Mohamed Abdel-Aziz, Ahmed Gareh, Fathy Osman, Fatma A. Elgohary, Ehssan Ahmed Hassan, Ehssan Ahmed Hassan, Noorah Alsowayeh, Hind Alzaylaee, Abd Al-Rahman S. Ahmed, Daniel Bravo-Barriga, Ehab Kotb Elmahallawy, Ehab Kotb Elmahallawy   +14 more
doaj   +1 more source

Fisiopatología de la sepsis por bacterias gram negativas: bases moleculares

Revista Cuarzo, 2015
La sepsis constituye un complejo síndrome en el que a consecuencia de una respuesta anómala del huésped frente a una infección se desencadenan una serie de mecanismos fi siopatológicos celulares y moleculares que se traducirán en el daño multiorgánico ...
Yardani Rafael Méndez Fandiño, María Claudia Barrera C.   +1 more
doaj   +1 more source