Results 11 to 20 of about 842,627 (287)

Molecular alterations during insulinoma tumorigenesis [PDF]

Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, 2007
Insulinomas are the most common functioning endocrine pancreatic tumors (EPTs). They present with clinical symptoms as a consequence of hypoglycemia induced by inappropriate insulin secretion. The etiology of these tumors is poorly understood. Some tumors may harbor MEN1 gene mutations, the susceptibility gene of the multiple endocrine neoplasia type I
Y M H, Jonkers, F C S, Ramaekers, E J M, Speel   +2 more
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Molecular alterations in pancreatic tumors

World Journal of Gastroenterology, 2021
Genetic alterations in pancreatic tumors can usually be classified in: (1) Mutational activation of oncogenes; (2) Inactivation of tumor suppressor genes; and (3) Inactivation of genome maintenance genes controlling the repair of DNA damage. Endoscopic ultrasound-guided fine-needle aspiration has improved pre-operative diagnosis, but the management of ...
Visani M., Acquaviva G., de Leo A., Sanza V., Merlo L., Maloberti T., Brandes A. A., Franceschi E., Di Battista M., Masetti M., Jovine E., Fiorino S., Pession A., Tallini G., de Biase D.   +14 more
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Molecular Alterations in Gastric Intestinal Metaplasia [PDF]

International Journal of Molecular Sciences, 2021
Gastric cancer (GC) remains one of the most common causes of mortality worldwide. Intestinal metaplasia (IM) is one of the preneoplastic gastric lesions and is considered an essential predisposing factor in GC development. Here we present a review of recent most relevant papers to summarize major findings on the molecular alterations in gastric IM. The
Paulius Jonaitis, Limas Kupcinskas, Juozas Kupcinskas   +2 more
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Molecular Alterations Associated with Osteosarcoma Development [PDF]

Sarcoma, 2012
Osteosarcoma is the most frequent malignant primary bone tumor characterized by a high potency to form lung metastases which is the main cause of death. Unfortunately, the conventional chemotherapy is not fully effective on osteosarcoma metastases.
Ando, Kosei, Mori, Kanji, Verrecchia, Franck, Baud'Huin, Marc, Rédini, Françoise, Heymann, Dominique   +5 more
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Molecular Alterations in Lung Adenocarcinoma With Ground-Glass Nodules: A Systematic Review and Meta-Analysis

Frontiers in Oncology, 2021
Background and AimsNodular ground-glass lesions have become increasingly common with the increased use of computed tomography (CT), while the genomic features of ground-glass opacities (GGOs) remain unclear. This study aims to comprehensively investigate
Zihan Wei, Zihan Wei, Ziyang Wang, Ziyang Wang, Yuntao Nie, Kai Zhang, Haifeng Shen, Xin Wang, Xin Wang, Manqi Wu, Manqi Wu, Fan Yang, Kezhong Chen   +12 more
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Research Progress of Key Molecular Events Related to Progression of Colorectal Cancer

Zhongliu Fangzhi Yanjiu, 2023
The continuous development of high-throughput and single-cell sequencing technologies and the emergence of spatial transcriptome sequencing have allowed the continuous discovery of temporal and spatial molecular events in the progression of colorectal ...
ZHOU Xiong, HU Ming, JIANG Dongming, CAO Guangwen, TAN Xiaojie   +4 more
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Molecular Alterations in Metastatic Ovarian Cancer From Gastrointestinal Cancer

Frontiers in Oncology, 2020
Reports indicate that most metastatic ovarian cancer (MOC) originates from gastrointestinal cancer (GIC). Notably, GICs metastasize to the ovary frequently via 3 main routes including hematogenous spread, lymphogenous spread, and transcoelomic spread ...
Chao Chen, Xiaoxu Ge, Xiaoxu Ge, Yamei Zhao, Da Wang, Limian Ling, Shu Zheng, Kefeng Ding, Jian Wang, Lifeng Sun   +9 more
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Basket Trials for Intractable Cancer

Frontiers in Oncology, 2019
Currently, genomic characterization has become standard of care for tumor types such as non-small cell lung cancer, breast cancer, melanoma, and colorectal cancer.
Bao-Dong Qin, Xiao-Dong Jiao, Ke Liu, Ying Wu, Xi He, Jun Liu, Wen-Xing Qin, Zhan Wang, Yuan-Sheng Zang   +8 more
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Molecular Alterations in Basal Cell Carcinoma Subtypes [PDF]

Scientific Reports, 2021
Abstract A number of genes have been implicated in the pathogenesis of BCC in addition to the Hedgehog pathway, which is known to drive the initiation of this tumour.We performed in-depth analysis of 13 BCC-related genes (CSMD1, CSMD2, DPH3 promoter, PTCH1, SMO, GLI1, NOTCH1, NOTCH2, TP53, ITIH2, DPP10, STEAP4, TERT promoter) in 57 BCC lesions (
Lucia Di Nardo, Cristina Pellegrini, Alessandro Di Stefani, Francesco Ricci, Barbara Fossati, Laura Del Regno, Carmine Carbone, Geny Piro, Vincenzo Corbo, Pietro Delfino, Simona De Summa, Maria Giovanna Maturo, Tea Rocco, Giampaolo Tortora, Maria Concetta Fargnoli, Ketty Peris   +15 more
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Molecular alterations associated with prostate cancer [PDF]

Central European Journal of Urology, 2018
The amount of information and knowledge about pathways and genetic alterations regarding prostate cancer, including the tools available for its study has been recently increasing. Additionally, a variety of molecular signaling pathways control cell proliferation, however, this incompletely understood process is disturbed in cancer cells.A literature ...
Garcia Perdomo, Herney Andres, Zapata-Copete, James A., Sanchez, Adalberto   +2 more
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