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Molecular mechanisms altering tubular calcium reabsorption
Pediatric Nephrology, 2021The majority of calcium filtered by the glomerulus is reabsorbed along the nephron. Most is reabsorbed from the proximal tubule (> 60%) via a paracellular pathway composed of the tight junction proteins claudins-2 and -12, a process driven by sodium and consequently water reabsorption.
Mallory L, Downie, R Todd, Alexander
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Pancreatic cancer — Molecular alterations
The Chinese-German Journal of Clinical Oncology, 2007Pancreatic ductal adenocarcinoma is a dismal disease with a median survival below 6 months and a 5 year survival rate below 1%. High mortality is due to early lymphatic and hematogenic dissemination. Effective therapies for local advanced or metastatic tumors are missing and curative resected patients relapse in over 80% of the cases.
Günter Schneider +2 more
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Molecular alterations in sarcomas
Current Opinion in Orthopaedics, 2001Within the last decade, advances in tumor cytogenetics and molecular biology have led to an explosion of information related to the underlying molecular alterations in sarcomas. Many sarcomas have characteristic genetic findings that shed light on mechanisms of tumorigenesis, serve as diagnostic ...
Brian P. Rubin, Jonathan A. Fletcher
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Molecular Alterations in Pediatric Solid Tumors
Surgical Pathology Clinics, 2021Pediatric tumors can be divided into hematologic malignancies, central nervous system tumors, and extracranial solid tumors of bone, soft tissue, or other organ systems. Molecular alterations that impact diagnosis, prognosis, treatment, and familial cancer risk have been described in many pediatric solid tumors.
Jonathan C, Slack, Alanna J, Church
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Tanning salon exposure and molecular alterations
Journal of the American Academy of Dermatology, 2001Human studies of the short-term cellular effects of tanning salon exposures are lacking. Findings of such studies may prove extremely helpful in educating consumers considering or currently attending tanning salons.Our purpose was to determine whether tanning salon exposure causes DNA alterations and p53 protein expression in epidermal keratinocytes ...
S E, Whitmore +3 more
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Molecular genetic alterations in pleomorphic xanthoastrocytoma
Acta Neuropathologica, 1996Pleomorphic xanthoastrocytoma (PXA) is a low-grade glioma that may recur as a malignant diffuse astrocytoma such as glioblastoma (GBM). While the molecular genetic basis of diffuse astrocytomas has been studied extensively, PXAs have not been analyzed in detail.
W, Paulus +6 more
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Molecular alterations in prostate cancer
Cancer Letters, 2008Prostate tumors display a range of clinical phenotypes, from indolent to aggressively metastatic. Numerous gene expression profiling studies have been conducted toward the potential molecular staging of these pathologies, however the identification of genetic markers that predict aggressive disease has not yet been demonstrated in the clinical setting.
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Molecular alterations in sporadic breast cancer
Critical Reviews in Oncology/Hematology, 2002Breast cancer is a genetic disease. Like other human cancers, it is thought to occur as the result of progressive accumulation of genetic aberrations. These aberrations result in a deviation of the gene expression profiles from that of the normal progenitor cell.
F, Lerebours, R, Lidereau
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Molecular alterations in uterine serous carcinoma
Gynecologic Oncology, 2010Uterine serous carcinoma (USC) is an aggressive endometrial cancer associated with poor prognosis despite comprehensive surgical staging and adjuvant chemotherapy and radiation therapy. Biologic targets have yet to be fully explored in this disease and research on such targets could lead to clinical trials utilizing a new class of therapeutics.A ...
Monica Prasad, Hayes +1 more
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Molecular alterations in meningiomas: Literature review
Clinical Neurology and Neurosurgery, 2019Meningiomas, tumors that originate from meningothelial cells, account for approximately 30% of all new diagnoses of central nervous system neoplasms. According to the 2016 WHO classification of central nervous system tumors meningiomas are classified into three grades: I, II, and III.
Benedito Jamilson Araújo, Pereira +3 more
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