Results 21 to 30 of about 842,627 (287)

Genomic alterations in thymoma—molecular pathogenesis? [PDF]

Journal of Thoracic Disease, 2020
Thymomas and thymic carcinomas (TCs) are neoplasms of thymic epithelial cells. Thymomas exhibit a low mutational burden and a few recurrently mutated genes. The most frequent missense mutation p.(Leu404His) affects the general transcription factor IIi (GTF2I) and is specific for thymic epithelial tumors (TETs).
Oberndorfer, Felicitas, Müllauer, Leonhard   +1 more
openaire   +2 more sources

Molecular Alterations in Sporadic Primary Hyperparathyroidism [PDF]

Genetics Research International, 2011
Primary hyperparathyroidism (PHPT) is a frequent endocrine disorder characterized by an excessive autonomous production and release of parathyroid hormone (PTH) by the parathyroid glands. This endocrinopathy may result from the development of a benign lesion (adenoma or hyperplasia) or from a carcinoma.
Alvelos, Maria Inês, Mendes, Maria, Soares, Paula   +2 more
openaire   +2 more sources

A review of the molecular mechanisms underlying the development and progression of cardiac remodeling [PDF]

, 2017
Pathological molecular mechanisms involved in myocardial remodeling contribute to alter the existing structure of the heart, leading to cardiac dysfunction.
Angelini, Francesco, Bordin, Antonella, Carrizzo, Albino, Chimenti, Isotta, DE FALCO, Elena, Forte, Maurizio, Frati, Giacomo, Nocella, Cristina, Pagano, Francesca, Palmerio, Silvia, Schiavon, Sonia, Schirone, Leonardo, Sciarretta, Sebastiano, Valenti, Valentina, Vecchione, Carmine, Yee, Derek   +15 more
core   +3 more sources

Molecular dynamics simulation of surfactant induced wettability alteration of shale reservoirs

Frontiers in Energy Research, 2023
Shale oil has recently received considerable attention as a promising energy source due to its substantial reserves. However, the recovery of shale oil presents numerous challenges due to the low-porosity and low-permeability characteristics of shale ...
Debin Kong, Debin Kong, Xianglong Meng, Xianglong Meng, Jiadan Zhu, Wenning Zhou   +5 more
doaj   +1 more source

Myelin pathology: Involvement of molecular chaperones and the promise of chaperonotherapy [PDF]

, 2019
The process of axon myelination involves various proteins including molecular chaperones. Myelin alteration is a common feature in neurological diseases due to structural and functional abnormalities of one or more myelin proteins.
Cappello F., Conway De Macario E., Macario A. J. L., Marino Gammazza A., Scalia F.   +4 more
core   +1 more source

Molecular Alterations in Thyroid Carcinoma

Surgical Pathology Clinics, 2019
Thyroid carcinoma is the most common cancer in the endocrine system. Recent advances, using next-generation sequencing, have shed light on the molecular pathogenesis of thyroid cancer. Constitutional activation of the mitogen-activated protein kinase pathway through RAS mutation, BRAF mutation, and/or fusions involving receptor tyrosine kinase (eg ...
Mohamed Rizwan, Haroon Al Rasheed, Bin, Xu   +1 more
openaire   +3 more sources

Sphingomyelin metabolism is involved in the differentiation of MDCK cells induced by environmental hypertonicity [PDF]

, 2015
Sphingolipids (SLs) are relevant lipid components of eukaryotic cells. Besides regulating various cellular processes, SLs provide the structural framework for plasma membrane organization.
Favale, Nicolas Octavio, Marquez, Maria Gabriela, Pescio, Lucila Gisele, Santacreu, Bruno Jaime, Sterin, Norma Beatriz   +4 more
core   +1 more source

Atrophy, oxidative switching and ultrastructural defects in skeletal muscle of the ataxia telangiectasia mouse model [PDF]

, 2019
Ataxia telangiectasia is a rare, multi system disease caused by ATM kinase deficiency. Atm-knockout mice recapitulate premature aging, immunodeficiency, cancer predisposition, growth retardation and motor defects, but not cerebellar neurodegeneration and
Aguanno, Salvatore, Bolasco, Giulia, De Angelis, Luciana, De Gennaro, Vincenzo, Marazziti, Daniela, Naro, Fabio, Pellegrini, Manuela, Sala, Gina La, Tassinari, Valentina   +8 more
core   +1 more source

Molecular Alterations in Meningioangiomatosis Causing Epilepsy

Journal of Neuropathology & Experimental Neurology, 2021
Abstract Meningioangiomatosis (MA) is a rare process at the intersection of cerebral developmental and neoplastic disorders that often results in epilepsy. We evaluated molecular alterations in MA to characterize its biology and pathogenesis. We searched a comprehensive institutional database for patients with MA treated between 2004 and
Antonio Dono, Azim Z Pothiawala, Cole T Lewis, Meenakshi B Bhattacharjee, Leomar Y Ballester, Nitin Tandon   +5 more
openaire   +2 more sources

Results of screening in early and advanced thoracic malignancies in the EORTC pan-European SPECTAlung platform

Scientific Reports, 2022
Access to a comprehensive molecular alteration screening is patchy in Europe and quality of the molecular analysis varies. SPECTAlung was created in 2015 as a pan-European screening platform for patients with thoracic malignancies.
M. Morfouace, S. Novello, A. Stevovic, C. Dooms, U. Janžič, T. Berghmans, R. Dziadziuszko, T. Gorlia, E. Felip, L. Paz-Ares, J. Mazieres, M. O’Brien, P. Bironzo, J. Vansteenkiste, L. Lacroix, A. C. Dingemans, V. Golfinopoulos, B. Besse   +17 more
doaj   +1 more source