Results 121 to 130 of about 6,161,194 (356)

Molecular Cloud Biology [PDF]

open access: yesarXiv
Some astrobiological models suggest that molecular clouds may serve as habitats for extraterrestrial life. This study reviews recent theoretical work addressing the physical and biochemical prerequisites for life in such environments, with particular focus on three subjects: (1) bioenergetic pathways under extreme low-temperature conditions; (2) the ...
arxiv  

Synthetic Biology in Leishmaniasis: Design,simulation and validation of constructed Genetic circuit [PDF]

open access: yesarXiv, 2013
Building circuits and studying their behavior in cells is a major goal of systems and synthetic biology. Synthetic biology enables the precise control of cellular states for systems studies, the discovery of novel parts, control strategies, and interactions for the design of robust synthetic systems. To the best of our knowledge,there are no literature
arxiv  

The molecular biology of arteriviruses.

open access: yesJournal of General Virology, 1998
.The establishment of an arterivirus family acknowledgesthemanyuniquebiologicalandmolecularpropertiesofitsfourpresent members. On the other hand, the affiliation with thecoronavirusesrecognizesanintriguingancestralrelationshipatthelevelofgenomeorganizationandreplication.ThegenomesequencesofEAV,PRRSV,LDVandSHFVwereinstrumentalin uniting and reclassifying ...
Snijder, E.J., Meulenberg, J.J.
openaire   +4 more sources

Circulating tumor cells in metastatic breast cancer patients treated with immune checkpoint inhibitors – a biomarker analysis of the ALICE and ICON trials

open access: yesMolecular Oncology, EarlyView.
In this explorative biomarker analysis, we assessed serial sampling of circulating tumor cells (CTCs) with CellSearch in two randomized trials testing immune checkpoint inhibitors (ICIs) in metastatic breast cancer. Our data demonstrate a prognostic potential of CTCs, most apparent 4 weeks into ICI therapy.
Nikolai Kragøe Andresen   +13 more
wiley   +1 more source

Base editing-coupled survival screening enabled high-sensitive analysis of PAM compatibility and finding of the new possible off-target

open access: yesiScience, 2021
Summary: Base editing (BE) is a promising genome engineering tool for modifying DNA or RNA and has been widely used in various microorganisms as well as eukaryotic cells.
Tianyuan Su   +6 more
doaj  

Circulating tumor cells: advancing personalized therapy in small cell lung cancer patients

open access: yesMolecular Oncology, EarlyView.
Small cell lung cancer (SCLC) is an aggressive form of lung cancer that spreads rapidly to secondary sites such as the brain and liver. Cancer cells circulating in the blood, “circulating tumor cells” (CTCs), have demonstrated prognostic value in SCLC, and evaluating biomarkers on CTCs could guide treatment decisions such as for PARP inhibitors ...
Prajwol Shrestha   +6 more
wiley   +1 more source

A comparative study of circulating tumor cell isolation and enumeration technologies in lung cancer

open access: yesMolecular Oncology, EarlyView.
Lung cancer cells were spiked into donor blood to evaluate the recovery rates of the following circulating tumor cell (CTC) enrichment technologies: CellMag™, EasySep™, RosetteSep™, Parsortix® PR1, and Parsortix® Prototype systems. Each method's advantages and disadvantages are described.
Volga M Saini   +11 more
wiley   +1 more source

Athena: Modular CAM/CAD Software for Synthetic Biology [PDF]

open access: yesarXiv, 2009
Synthetic biology is the engineering of cellular networks. It combines principles of engineering and the knowledge of biological networks to program the behavior of cells. Computational modeling techniques in conjunction with molecular biology techniques have been successful in constructing biological devices such as switches, oscillators, and gates ...
arxiv  

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