Results 101 to 110 of about 398,640 (265)

An update on molecular biology of thyroid cancers [PDF]

, 2014
Differentiated thyroid cancer (DTC) is the most common endocrinological malignancy. There are several histological variants such as papillary and follicular thyroid carcinoma.
Baran, Yusuf, Ömür, Özgür
core   +1 more source

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

FEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source

Epigenetic blind spots – the role of DNA methylation dynamics in stem cell‐based models of embryogenesis

FEBS Letters, EarlyView.
Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil, Anna Corrà, Annalisa Scapolatiello, Chengxiang Qiu, Gianluca Amadei   +4 more
wiley   +1 more source

HMMR/RHAMM recruits SACK1D/FAM83D-CK1α complex at the mitotic spindle to control spindle alignment

iScience
Summary: The SACK1D/FAM83D-CK1α complex assembles at the mitotic spindle to orchestrate proper spindle positioning and error-free progression through mitosis.
Tyrell N. Cartwright, Naveen K. Nakarakanti, Karen Dunbar, Luke J. Fulcher, Selina Bader, Nicola T. Wood, Thomas J. Macartney, Gopal P. Sapkota   +7 more
doaj   +1 more source

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

FEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

Evolutionary cell biology: Functional insight from “Endless forms most beautiful” [PDF]

, 2015
In animal and fungal model organisms, the complexities of cell biology have been analyzed in exquisite detail and much is known about how these organisms function at the cellular level.
Richardson, Elizabeth, Dacks, Joel B., Tsaousis, Anastasios D., Dorrell, Richard G., Zerr, Kelly   +4 more
core   +1 more source

Single-cell RNA-sequencing of dermal fibroblasts demonstrates culture-induced changes and variable persistence of keloid disease features

iScience
Summary: In vitro models of scarring and fibrosis are essential to improve our understanding of disease mechanisms and ultimately develop much-needed therapeutic strategies.
Amy Lock, Elena M. Drudi, Dasha Freydina, Brian M. Stramer, Franziska Denk, Tanya J. Shaw   +5 more
doaj   +1 more source

Residual tail twisting in ascidian larvae is stabilized by asymmetric myofibrils that resist bilateral symmetry restoration

FEBS Letters, EarlyView.
Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure, Misaki K. Nishio, Satoru Okuda, Kohji Hotta   +3 more
wiley   +1 more source

The Molecular Biology Notebook on CD-ROM - a step toward the virtual laboratory

, 1999
The Molecular Biology Notebook is a teaching tool for molecular biology, developed at the Institute of Arable Crops Research, Rothamsted, in association with local schools and the University of Luton.
Castells-Brooke, N. I. D., Mullins, R., Nathalie Castells-Brooke, Paul Verrier, John Antoniw, Roisin Mullins, Antoniw, J. F., Verrier, P. J.   +7 more
core   +1 more source

Biophysical approaches for studying viral entry

FEBS Letters, EarlyView.
Viruses infect all living organisms and have been responsible for major epidemics and pandemics. Their ongoing evolutionary battle with host defenses creates a constant need for improved tools to study viral behavior. Advancing methods to probe viral attachment, fusion, and genome release deepen our understanding of how infections begin and support the
Inbar Yosibash, Raya Sorkin
wiley   +1 more source