Results 81 to 90 of about 2,246,680 (313)

Systems biology of cell behavior [PDF]

, 2010
Systems Biology approaches to drug discovery largely focus on the increasing understanding of intracellular and cellular circuits, by computational representation of a molecular system followed by parameter validation against experimental data.
Umezawa Y., Valeyev N., Bates D., Kotov N., Gizatullina A.   +4 more
core  

Mesenchymal Hippo signaling regulates intestinal homeostasis in adult mice

iScience
Summary: Intestinal homeostasis is tightly regulated by the reciprocal interaction between the gut epithelium and adjacent mesenchyme. The Hippo pathway is intimately associated with intestinal epithelial homeostasis and regeneration; however, its role ...
Kyvan Dang, Alka Singh, Xin Chen, Jennifer L. Cotton, Susu Guo, Xiaodi Hu, Zhipeng Tao, Haibo Liu, Lihua J. Zhu, Y. Tony Ip, Xu Wu, Junhao Mao   +11 more
doaj   +1 more source

Graphs in molecular biology

BMC Bioinformatics, 2007
Graph theoretical concepts are useful for the description and analysis of interactions and relationships in biological systems. We give a brief introduction into some of the concepts and their areas of application in molecular biology.
Falcon Seth, Long Li, Carey Vincent J, Huber Wolfgang, Gentleman Robert   +4 more
doaj   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source

Molecular biology of B cells / [PDF]

Molecular Biology of B Cells, Second Edition is a comprehensive reference to how B cells are generated, selected, activated and engaged in antibody production. All of these developmental and stimulatory processes are described in molecular, immunological,
Honjō, Tasuku,editor., Radbruch, A.(Andreas),editor., Alt, Frederick W.,editor., Reth, Michael,editor.   +3 more
core  

Molecular Biology of Medulloblastoma

Pediatric Neurology Briefs, 2007
Current methods of diagnosis and treatment of medulloblastoma, and the influence of new biological advances in the development of more effective and less toxic therapies are reviewed by researchers at Children’s National Medical Center, The George ...
J Gordon Millichap
doaj   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Protocol for preparing monosodium urate crystals for in vitro and in vivo studies in mouse and human cells

STAR Protocols
Summary: Gout is caused by the deposition of monosodium urate crystals (MSUc) in the joints, triggering a unique inflammatory and metabolic response in macrophages.
Mohnish Alishala, Ru Liu-Bryan, Isidoro Cobo   +2 more
doaj   +1 more source

Sounds of molecular biology

BioTechniques, 2016
Engineers and biologists are using sound to mix fluids, move cells, and dispense liquids. Nathan Blow looks at how acoustic science is changing molecular biology and high-throughput screening.
Nathan Blow
doaj   +1 more source