Results 81 to 90 of about 7,134,993 (310)
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
STAR ProtocolsSummary: Gout is caused by the deposition of monosodium urate crystals (MSUc) in the joints, triggering a unique inflammatory and metabolic response in macrophages.
Mohnish Alishala +2 more
doaj +1 more source
The Best of Molecular Biology [PDF]
Molecular Cell, 1997 Molecular biology is not so much maturing as a field as extending its tentacles into all of modern biology. This development has been a major factor in the success of Cell and has more than vindicated our original intention of publishing a “Journal of Exciting Biology” that would provide a unifying forum in which research on apparently diverse topics ...
openaire +2 more sources
Systems biology in animal sciences [PDF]
, 2011 Systems biology is a rapidly expanding field of research and is applied in a number of biological disciplines. In animal sciences, omics approaches are increasingly used, yielding vast amounts of data, but systems biology approaches to extract ...
Pas, M.F.W., te +10 more
core +1 more source
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
iScienceSummary: Obstructive sleep apnea (OSA) is a common sleep disordered breathing diseases that characterized by chronic intermittent hypoxia (CIH). This work aimed to explore the role of circ-CIMIRC in CIH-induced myocardial injury.
Runhua Wu +6 more
doaj +1 more source
British Journal of Anaesthesia, 1995 We have attempted to define some of the patterns of expression of the IEG Fos in pain-related states. On one level, Fos may be used simply as marker of afferent stimulation and disease state, and in this respect Fos activation may be a useful tool after nociceptive stimulation to examine the effectiveness of different analgesic regimens.
R, Munglani, S P, Hunt
openaire +2 more sources
Biochemistry, molecular biology, and genetics.
, 2014 Includes index.pharmacy bookfair2015Rev. ed. of: Biochemistry, molecular biology, and genetics / Todd A. Swanson, Sandra I. Kim, Marc J. Glucksman. 5th ed. c2010.ix, 449 p.
Lieberman, Michael, 1950- +1 more
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The phosphoinositide family of membrane lipids play diverse and critical roles in eukaryotic molecular biology. Much of this biological activity derives from interactions of phosphoinositide lipids with integral and peripheral membrane proteins, leading ...
Yen, Hsin-Yung, Hedger, George
core +1 more source
Systems biology of cell behavior [PDF]
, 2010 Systems Biology approaches to drug discovery largely focus on the increasing understanding of intracellular and cellular circuits, by computational representation of a molecular system followed by parameter validation against experimental data.
Umezawa Y. +4 more
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