Results 91 to 100 of about 398,640 (265)
Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation
FEBS Letters, EarlyView.Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz +11 more
wiley +1 more source
The phosphoinositide family of membrane lipids play diverse and critical roles in eukaryotic molecular biology. Much of this biological activity derives from interactions of phosphoinositide lipids with integral and peripheral membrane proteins, leading ...
Yen, Hsin-Yung, Hedger, George
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A Richer and More Diverse Future for Cell Biology
, 2010 Our vision: within the next few decades the composition of the faculty of cell biology, and of all biological science departments, will reflect the diverse composition of the graduate students in those departments.
Virginia Valian +14 more
core +1 more source
Mechanisms of Action for Small Molecules Revealed by Structural Biology in Drug Discovery
, 2020 Small-molecule drugs are organic compounds affecting molecular pathways by targeting important proteins. These compounds have a low molecular weight, making them penetrate cells easily.
Qingxin Li, CongBao Kang
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An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane
FEBS Letters, EarlyView.Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa +3 more
wiley +1 more source
, 2008 Though completely up-to-date with the latest research advances, the Sixth Edition of James D. Watson's classic book, Molecular Biology of the Gene retains the distinctive character of earlier editions that has made it the most widely used book in ...
Gann, A. +5 more
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Phenotypic bistability in Escherichia coli's central carbon metabolism [PDF]
, 2014 Fluctuations in intracellular molecule abundance can lead to distinct, coexisting phenotypes in isogenic populations. Although metabolism continuously adapts to unpredictable environmental changes, and although bistability was found in certain substrate ...
Volkmer, Benjamin +9 more
core +1 more source
Cell biology and molecular biology.
Advances in cytopharmacology, 1968 info:eu-repo/semantics ...
openaire +4 more sources
The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes
FEBS Letters, EarlyView.Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga +3 more
wiley +1 more source
On microRNA and the Need for Exploratory Experimentation in Post-Genomic Molecular Biology [PDF]
, 2007 This paper is devoted to an examination of the discovery, characterization, and analysis of the functions of microRNAs, which also serves as a vehicle for demonstrating the importance of exploratory experimentation in current (post-genomic) molecular ...
Burian, Richard M., Richard M. Burian
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