Results 61 to 70 of about 7,134,993 (310)

Dual specificity kinase DYRK3 regulates cell migration by influencing the stability of protrusions

iScience
Summary: Plasma membrane-associated platforms (PMAPs) form at specific sites of plasma membrane by scaffolds including ERC1 and Liprin-α1. We identify a mechanism regulating PMAPs assembly, with consequences on motility/invasion. Silencing Ser/Thr kinase
Martina Ramella, Lucrezia Maria Ribolla, Sara Surini, Kristyna Sala, Diletta Tonoli, Jean-Michel Cioni, Arpan Kumar Rai, Lucas Pelkmans, Ivan de Curtis   +8 more
doaj   +1 more source

The human gut microbiome across the life course

FEBS Letters, EarlyView.
Despite significant individual variation and continuous change throughout life, the human gut microbiome follows some life stage‐specific trends. This article provides a brief overview of how gut microbiome composition shifts across different phases of life. Created in BioRender. Özkurt, E. (2026) https://BioRender.com/8q4nrnc.
Alise J. Ponsero, Basak Bahcivanci, Antonietta Hayhoe, Animesh Acharjee, Ezgi Özkurt   +4 more
wiley   +1 more source

Histidine-Rich Glycoprotein Inhibits High-Mobility Group Box-1-Mediated Pathways in Vascular Endothelial Cells through CLEC-1A

iScience, 2020
Summary: High-mobility group box-1 (HMGB1) protein has been postulated to play a pathogenic role in severe sepsis. Histidine-rich glycoprotein (HRG), a 75 kDa plasma protein, was demonstrated to improve the survival rate of septic mice through the ...
Shangze Gao, Hidenori Wake, Masakiyo Sakaguchi, Dengli Wang, Youhei Takahashi, Kiyoshi Teshigawara, Hui Zhong, Shuji Mori, Keyue Liu, Hideo Takahashi, Masahiro Nishibori   +10 more
doaj   +1 more source

Molecular biology of the gut [PDF]

Molecular and Cellular Pediatrics, 2016
Editorial The gastrointestinal tract is the largest exposed surface among mammalian macroorganisms. It is constantly exposed to substantial challenges and exerts a potpourri of diverse physiological functions. Among the major intestinal functions is the digestion of nutrients and subsequent uptake and metabolism of their respective building blocks ...
Naim, Hassan Y., Zimmer, Klaus-Peter, Nichols, Buford   +2 more
openaire   +2 more sources

Molecular Biology: Challenges and Opportunities

“Latest Review Papers in Molecular Biology 2024”, a Special Issue of Current Issues in Molecular Biology (CIMB) that I have had the privilege of editing, called for articles on the challenges and opportunities in the field of molecular biology [...
Madhav Bhatia
core   +1 more source

Multiple roles of STAT3 in cardiovascular inflammatory responses

, 2012
10.1016/B978-0-12-396456-4.00010-9Progress in Molecular Biology and Translational Science10663 ...
Cheh Peng Lim, Xin-Yuan Fu, Fu, X.-Y., Lim, C.P.   +3 more
core   +1 more source

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

Integrated structural biology of the native malarial translation machinery and its inhibition by an antimalarial drug [PDF]

Our understanding of cellular events is hampered by the gap between the resolution at which we can observe events inside cells and our ability to replicate physiological conditions in test tubes.
Lee, Carolyn L, Wang, Hanyu, Cheng, Wenjing, Zhu, Xiyan, Anton, Leonie, Han, Leyan, Ho, Chi-Min, Cheng, W, Ho, CM, Li, E, Li, Emerson, Wang, H, Doud, Emma H., Ke, H, Zhu, X, Lee, CL, Ke, Hangjun, Cobb, DW, Han, L, Cowman, Alan F., Anton, L, Cowman, AF, Haile, MT, Haile, Meseret T., Dziekan, Jerzy M., Zhang, Guoan, Doud, EH, Zhang, G, Dziekan, JM, Cobb, David W., Nair, Anjali, Nair, A   +31 more
core   +1 more source

Salmonella lipopolysaccharide‐containing supported lipid bilayers as platforms to study bacteriophage interactions

FEBS Letters, EarlyView.
We present robust protocols for the preparation of supported lipid bilayers (SLBs) incorporating either Salmonella smooth LPS or outer membrane vesicles (OMVs). We use a combination of quartz crystal microbalance with dissipation (QCM‐D) and fluorescence microscopy to both characterize the SLBs of various compositions and to probe their interactions ...
Hudson P. Pace, Alyssa Borges, Charles Arnaud, Tove Karlsson, Nina K. Bröker, Stefanie Barbirz, Marta Bally   +6 more
wiley   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source