Results 61 to 70 of about 398,640 (265)

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Rate of isomerisation of peptidyl-proline bonds as a probe for interactions in the physiological denatured state of chymotrypsin inhibitor 2

, 1997
10.1006/jmbi.1997.1043Journal of Molecular Biology2694611 ...
Oliveberg, M., Otzen, Daniel E, Tan, Yee-Joo, Oliveberg, Mikael, Oliveberg, Mikael,, Tan, Y.-J., Otzen, D.E., Fersht, Alan R, Fersht, A.R., Lund University.   +9 more
core   +1 more source

Molecular Biology of Spermatogenesis: Novel Targets of Apparently Idiopathic Male Infertility

, 2020
Male infertility affects half of infertile couples and, currently, a relevant percentage of cases of male infertility is considered as idiopathic. Although the male contribution to human fertilization has traditionally been restricted to sperm DNA ...
Rosita A. Condorelli, Aldo E. Calogero, Laura M. Mongioì, Sandro La Vignera, Rossella Cannarella   +4 more
core   +1 more source

Plant Molecular Biology Databases

Highlights in BioScience, 2019
Many plant biological database comprises data from study fields including metabolomics, proteomics, genomics, microarray gene expression, and phylogenetic. Information in biological databases involves the role of genes, composition, chromosomal location,
Zubair Awan, Aqib Ali, Abbas Iqbal
doaj   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Shifting Attention From Theory to Practice in Philosophy of Biology [PDF]

, 2013
Traditional approaches in philosophy of biology focus attention on biological concepts, explanations, and theories, on evidential support and inter-theoretical relations.
Waters, C. Kenneth, C. Kenneth Waters
core   +1 more source

Histidine-Rich Glycoprotein Inhibits High-Mobility Group Box-1-Mediated Pathways in Vascular Endothelial Cells through CLEC-1A

iScience, 2020
Summary: High-mobility group box-1 (HMGB1) protein has been postulated to play a pathogenic role in severe sepsis. Histidine-rich glycoprotein (HRG), a 75 kDa plasma protein, was demonstrated to improve the survival rate of septic mice through the ...
Shangze Gao, Hidenori Wake, Masakiyo Sakaguchi, Dengli Wang, Youhei Takahashi, Kiyoshi Teshigawara, Hui Zhong, Shuji Mori, Keyue Liu, Hideo Takahashi, Masahiro Nishibori   +10 more
doaj   +1 more source

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

FEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes, Jan Brysch, Carmen Gelze, Lilli Meier, Daniel Kümmel   +4 more
wiley   +1 more source

Representing and analysing molecular and cellular function in the computer

, 2000
Determining the biological function of a myriad of genes, and understanding how they interact to yield a living cell, is the major challenge of the post genome-sequencing era.
Naim, A., Helden, J., Van, Wernisch, L, Eldridge, M, Wodak, S. J., Gilbert, D, Mancuso, R, Helden, JV, Wodak, SJ, Helden, J.,, Wernisch, Lorenz, Naim, A, Wernisch, L., Eldridge, Matthew, van Helden, Jacques, Mancuso, R., Wodak, Shoshana, Eldridge, M., Mancuso, Renato, Gilbert, D.   +19 more
core   +1 more source

Remodeling of the secretory pathway is coordinated with de novo membrane formation in budding yeast gametogenesis

iScience
Summary: Gametogenesis in budding yeast involves a large-scale rearrangement of membrane traffic to allow the de novo formation of a membrane, called the prospore membrane (PSM). However, the mechanism underlying this event is not fully elucidated. Here,
Yasuyuki Suda, Hiroyuki Tachikawa, Tomomi Suda, Kazuo Kurokawa, Akihiko Nakano, Kenji Irie   +5 more
doaj   +1 more source