Advanced Healthcare Materials, EarlyView.To dissect how mechanical forces influence intestinal physiology, we developed a stretchable 3D colon‐on‐chip that integrates tunable topography, stiffness and peristalsis‐like motion within a physiologically relevant microenvironment. We showed that stretching is a dominant factor governing epithelial behavior, markedly enhancing proliferation and ...
Moencopi Bernheim‐Dennery +10 more
wiley +1 more source
Macromolecular crystallography for mammalian body temperature in support of molecular biophysics methods. [PDF]
Biophys RevBrink A, Helliwell JR, Jacobs FJF.
europepmc +1 more source
Respiratory Organ‐on‐a‐Chip for Disease Modeling: From Architecture to Functional Integration
Advanced Healthcare Materials, EarlyView.Respiratory organ‐on‐a‐chip (ROC) models capture key mechanical and cellular cues of the human respiratory system, enabling quantitative dissection of disease mechanisms. This review links ROC architectures to disease modeling, functional integration, and commercialization, and proposes a decision framework that aligns model complexity with mechanistic
Jinzhuo Hu +4 more
wiley +1 more source
Editorial: Molecular Organization of Membranes: Where Biology Meets Biophysics
Frontiers in Cell and Developmental Biology, 2017 Marek Cebecauer, David Holowka
doaj +1 more source
State-of-the-Art Molecular Biophysics in Russia. [PDF]
Int J Mol SciGalzitskaya OV.
europepmc +1 more source
Advanced Healthcare Materials, EarlyView.A superhydrophobic 3D cell culture platform enables rapid and consistent formation of heterotypic tumor–stroma clusters, and reveals how physiological shear conditions influence metastatic signaling. Mechanical stimulation of cancer‐associated fibroblasts promotes sustained cytokine secretion and survival‐promoting pathways, showing how multicellular ...
Alexandria T. Carter +5 more
wiley +1 more source
Molecular biophysics and inhibition mechanism of influenza virus A M2 viroporin by adamantane-based drugs - Challenges in designing antiviral agents. [PDF]
J Struct Biol XGeorgiou K, Kolokouris D, Kolocouris A.
europepmc +1 more source
Doing molecular biophysics: finding, naming, and picturing signal within complexity. [PDF]
Annu Rev Biophys, 2013 Richardson JS, Richardson DC.
europepmc +1 more source
3D Soft Hydrogels Induce Human Mesenchymal Stem Cells “Deep” Quiescence
Advanced Healthcare Materials, EarlyView.Three‐dimensional soft hydrogels mimicking the bone marrow niche induce deep quiescence in human mesenchymal stem cells. Unlike 2D culture, 3D matrices halt proliferation, regulate cell‐cycle and quiescence markers, and downregulate mTORC1 signaling, preserving stem cell phenotype and therapeutic potential ex vivo.
David Boaventura Gomes +11 more
wiley +1 more source
Machine learning in molecular biophysics: Protein allostery, multi-level free energy simulations, and lipid phase transitions. [PDF]
Biophys Rev (Melville)Cui Q.
europepmc +1 more source