Results 71 to 80 of about 507,440 (288)
Tumor mutational burden as a determinant of metastatic dissemination patterns
Molecular Oncology, EarlyView.This study performed a comprehensive analysis of genomic data to elucidate whether metastasis in certain organs share genetic characteristics regardless of cancer type. No robust mutational patterns were identified across different metastatic locations and cancer types.
Eduardo Candeal +4 more
wiley +1 more source
OpenEar: an ultra-affordable, high-throughput, and accurate maize ear phenotyping system
Plant MethodsCrop phenotyping of important agronomic traits in field conditions at single-plant resolution has long been a major bottleneck in both genetic analysis (e.g. large-scale association/linkage analysis) and breeding applications (e.g.
Shaoqi Fan +11 more
doaj +1 more source
Implications of avoiding overlap between training and testing data sets when evaluating genomic predictions of genetic merit [PDF]
, 2010 The aim of this study was to evaluate and quantify the importance of avoiding overlap between training and testing subsets of data when evaluating the effectiveness of predictions of genetic merit based on genetic markers.
Amer, P. R., Banos, G.
core +1 more source
Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin
Molecular Oncology, EarlyView.Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon +4 more
wiley +1 more source
Proceedings of the COST SUSVAR/ECO-PB Workshop on organic plant breeding strategies and the use of molecular markers [PDF]
, 2005 In many countries,national projects are in progress to investigate the sustainable low-input approach.In the present COST network,these projects are coordinated by means of exchange of materials,establishing common methods for assessment and statistical ...
core
Evolutionary plant breeding for low input systems [PDF]
, 2005 Heritable variation is at the heart of the process of evolution. However, variation is restricted in breeding for uniform crop populations using the pedigree line approach. Pedigree lines are successful in agriculture because synthetic inputs are used to
Phillips, Scott, Wolfe, Martin
core +1 more source
Molecular Oncology, EarlyView.To integrate multiple transcriptomics data with severe batch effects for identifying MB subtypes, we developed a novel and accurate computational method named RaMBat, which leveraged subtype‐specific gene expression ranking information instead of absolute gene expression levels to address batch effects of diverse data sources.
Mengtao Sun, Jieqiong Wang, Shibiao Wan
wiley +1 more source
Frontiers in Plant ScienceMetal tolerance protein (MTP) family members, functioning as plant divalent cation transporters, play essential roles in maintaining heavy metal homeostasis and tolerance. This study presents a novel comprehensive genomic characterisation of the MTP gene
Yi Zhang +15 more
doaj +1 more source
Molecular Oncology, EarlyView.This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns +10 more
wiley +1 more source
Privatised provision of essential plant breeding infrastructure [PDF]
As private plant breeding replaces public programs, the efficient provision and utilisation of key enabling technologies for crop breeding, which are largely knowledge based and provide the foundation for variety improvement, might be at risk. Typically,
Lindner, Robert K.
core +1 more source