Results 61 to 70 of about 3,853,576 (297)

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

Molecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu, Puspa Das, Xing Zhang, Xiaodong Cheng   +3 more
wiley   +1 more source

Host genetics and gut microbiota synergistically regulate feed utilization in egg-type chickens

Journal of Animal Science and Biotechnology
Background Feed efficiency is a crucial economic trait in poultry industry. Both host genetics and gut microbiota influence feed efficiency. However, the associations between gut microbiota and host genetics, as well as their combined contributions to ...
Wenxin Zhang, Fangren Lan, Qianqian Zhou, Shuang Gu, Xiaochang Li, Chaoliang Wen, Ning Yang, Congjiao Sun   +7 more
doaj   +1 more source

Analysis of QTLs on heading date based on single segment substitution lines in rice (Oryza Sativa L.)

Scientific Reports, 2018
Single segment substitution lines (SSSLs) have been confirmed to be powerful tools to perform quantitative trait locus (QTL) analysis. This study illuminated the process and methods of QTL analysis with SSSLs on heading date (HD) in rice.
Haitao Zhu, Yun Li, Jiayan Liang, Xin Luan, Pan Xu, Shaokui Wang, Guiquan Zhang, Guifu Liu   +7 more
doaj   +1 more source

CEACAM1 participation in breast cancer progression

Molecular Oncology, EarlyView.
In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin, Irina Kube‐Golovin, Anatolii Romaniuk, Gunther Wennemuth   +3 more
wiley   +1 more source

Annual report 2017: CGIAR Excellence in Breeding Platform [PDF]

, 2018
The platform leader was hired in August of 2017. The platform leader, Michael Quinn, and CIMMYT DDG, Marianne Bänziger, visited a large number of CGIAR-supported breeding programs – Africa Rice (Nigeria), CIAT (Colombia), CIMMYT (Kenya, India, Mexico ...
CGIAR Excellence in Breeding Platform
core   +1 more source

Deciphering the coordinated roles of the host genome, duodenal mucosal genes, and microbiota in regulating complex traits in chickens

Microbiome
Background The complex interactions between host genetics and the gut microbiome are well documented. However, the specific impacts of gene expression patterns and microbial composition on each other remain to be further explored.
Fangren Lan, Xiqiong Wang, Qianqian Zhou, Xiaochang Li, Jiaming Jin, Wenxin Zhang, Chaoliang Wen, Guiqin Wu, Guangqi Li, Yiyuan Yan, Ning Yang, Congjiao Sun   +11 more
doaj   +1 more source

Paclitaxel induces NM2‐dependent cellular contraction through GEF‐H1 dissociation from microtubules and RhoA/ROCK activation in cancer cells

Molecular Oncology, EarlyView.
Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez, Rafael Pérez‐Díaz, Hugo Ramos‐Solano, Marina Garrido‐Casado, Vanessa C. Talayero, Miguel Vicente‐Manzanares   +5 more
wiley   +1 more source

Transcriptomic and epigenomic landscapes of muscle growth during the postnatal period of broilers

Journal of Animal Science and Biotechnology
Background Broilers stand out as one of the fastest-growing livestock globally, making a substantial contribution to animal meat production. However, the molecular and epigenetic mechanisms underlying the rapid growth and development of broiler chickens ...
Shuang Gu, Qiang Huang, Yuchen Jie, Congjiao Sun, Chaoliang Wen, Ning Yang   +5 more
doaj   +1 more source

Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae

FEBS Open Bio, EarlyView.
Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj, Eline M. F. de Lange, Klaas A. Sjollema, Ben N. G. Giepmans   +3 more
wiley   +1 more source

OpenEar: an ultra-affordable, high-throughput, and accurate maize ear phenotyping system

Plant Methods
Crop phenotyping of important agronomic traits in field conditions at single-plant resolution has long been a major bottleneck in both genetic analysis (e.g. large-scale association/linkage analysis) and breeding applications (e.g.
Shaoqi Fan, Guoji Li, Revocatus Bahitwa, Zhiguo Jia, Hongwei Zhang, Jinghong Shao, Qiuying Yu, Xiaoran Chen, Yiheng Qian, Mingchi Xu, Linlin Zhu, Hai Wang   +11 more
doaj   +1 more source