Results 131 to 140 of about 4,011,919 (357)
Advanced Science, EarlyView.Hyaluronic acid‐modified bimetallic peroxide nanocomposites (MgO2‐CuO2@HA) are designed for synergistic tumor therapy. The nanocomposites release Mg2+, H2O2, and Cu2+ in tumor cells, induce cuproptosis via Cu+‐mediated protein aggregation, and activate pyroptosis through caspase‐1/gasdermin D pathways for inducing immunogenic cell death, collectively ...
Guanting He +8 more
wiley +1 more source
Disaggregases, molecular chaperones that resolubilize protein aggregates
Anais da Academia Brasileira de Ciências, 2015 The process of folding is a seminal event in the life of a protein, as it is essential for proper protein function and therefore cell physiology. Inappropriate folding, or misfolding, can not only lead to loss of function, but also to the formation of ...
David Z. Mokry +2 more
doaj +1 more source
Neuroprotection targeting protein misfolding on chronic cerebral hypoperfusion in the context of metabolic syndrome [PDF]
, 2018 Metabolic syndrome (MetS) is a cluster of risk factors that lead to microvascular dysfunction and chronic cerebral hypoperfusion (CCH). Long-standing reduction in oxygen and energy supply leads to brain hypoxia and protein misfolding, thereby linking CCH
Capani, Francisco +6 more
core +1 more source
SnapShot: Molecular Chaperones, Part II
Cell, 2007 DnaK/1DKG; 1DKZ 69/monomer DnaJ, GrpE, ClpB Cytosol/folding of nascent proteins; export of some proteins; reactivates heat-inactivated proteins; facilitates abnormal protein degradation; works with ClpB in protein aggregate disassembly; regulates heat-shock response.Archaea Methanosarcinae DnaK 67/monomer DnaJ, GrpE Cytosol/similar to bacterial DnaK ...
Chang, H. +3 more
openaire +5 more sources
Cellular and Molecular Life Sciences, 2014 By virtue of their general ability to bind (hold) translocating or unfolding polypeptides otherwise doomed to aggregate, molecular chaperones are commonly dubbed “holdases”.
Rayees U. H. Mattoo, P. Goloubinoff
semanticscholar +1 more source
Advanced Science, EarlyView.A post‐stroke perivascular niche of microglia characterized by low expression of M2 markers and elevated glycolysis, oxidative phosphorylation (OXPHOS), and phagocytic activity is identified, which is termed stroke‐activated vascular‐associated microglia (stroke‐VAM).
Yanan Li +8 more
wiley +1 more source
The redox switch that regulates molecular chaperones
Biomolecular Concepts, 2015 Modification of reactive cysteine residues plays an integral role in redox-regulated reactions. Oxidation of thiolate anions to sulphenic acid can result in disulphide bond formation, or overoxidation to sulphonic acid, representing reversible and ...
Conway Myra E., Lee Christopher
doaj +1 more source
Aneuploidy and proteotoxic stress in cancer [PDF]
, 2015 Although nearly ubiquitous in cancer, aneuploidy exerts detrimental effects on human cells. We recently demonstrated that aneuploid human cells exhibit impaired heat shock factor protein 1 (HSF1) and HSP90 function, suggesting a functional link between ...
Donnelly, N., Storchova, Z.
core +2 more sources
Advanced Science, EarlyView.Dual genetic strategies for improving wheat processing quality by regulating purothionin accumulation to modulate gluten quantity and quality. The first strategy involves targeting signal peptide (SP) cleavage sites (e.g., through mutation) to indirectly reduce gluten content, thereby disrupting gluten network formation.
Yijie Liu +16 more
wiley +1 more source