Results 41 to 50 of about 7,940,505 (313)

Probing contacts of inhibitor locked in transition states in the catalytic triad of DENV2 type serine protease and its mutants by 1H, 19F and 15 N NMR spectroscopy

BMC Molecular and Cell Biology, 2020
Background Detailed structural knowledge of enzyme-inhibitor complexes trapped in intermediate state is the key for a fundamental understanding of reaction mechanisms taking place in enzymes and is indispensable as a structure-guided drug design tool ...
Peter Agback, Esmeralda Woestenenk, Tatiana Agback   +2 more
doaj   +1 more source

A High-Throughput, Precipitating Colorimetric Sandwich ELISA Microarray for Shiga Toxins

Toxins, 2014
Shiga toxins 1 and 2 (Stx1 and Stx2) from Shiga toxin-producing E. coli (STEC) bacteria were simultaneously detected with a newly developed, high-throughput antibody microarray platform.
Andrew Gehring, Xiaohua He, Pina Fratamico, Joseph Lee, Lori Bagi, Jeffrey Brewster, George Paoli, Yiping He, Yanping Xie, Craig Skinner, Charlie Barnett, Douglas Harris   +11 more
doaj   +1 more source

MOLECULAR CHARACTERIZATION OF SOME PATHOGENIC BACTERIA ISOLATED FROM MAYONNAISE [PDF]

Assiut Veterinary Medical Journal, 2019
The purpose of this study was to determine the molecular characterization of some pathogenic bacteria isolated from commercial and small producers mayonnaise sold in restaurants and supermarkets in Assiut governorate.
MARWA EL-GENDI, MANAL M. AMIN
doaj   +1 more source

Validation and Evaluation of High-Resolution Orbitrap Mass Spectrometry on Molecular Characterization of Dissolved Organic Matter

ACS Omega, 2020
Molecular composition of dissolved organic matter (DOM) is a hot topic in subjects such as environmental science and geochemistry. Fourier transform ion cyclotron resonance mass spectrometry (FT-ICR MS) has been applied to molecular composition ...
Qiong Pan, Xiaocun Zhuo, Chen He, Yahe Zhang, Quan Shi   +4 more
semanticscholar   +1 more source

COMPREHENSIVE MOLECULAR CHARACTERIZATION OF CLEAR CELL RENAL CELL CARCINOMA

Nature, 2013
Genetic changes underlying clear cell renal cell carcinoma (ccRCC) include alterations in genes controlling cellular oxygen sensing (for example, VHL) and the maintenance of chromatin states (for example, PBRM1).
The Cancer Genome Atlas Research Network
semanticscholar   +1 more source

Molecular characterization of the evolution of phagosomes

Molecular Systems Biology, 2010
Amoeba use phagocytosis to internalize bacteria as a source of nutrients, whereas multicellular organisms utilize this process as a defense mechanism to kill microbes and, in vertebrates, initiate a sustained immune response. By using a large-scale approach to identify and compare the proteome and phosphoproteome of phagosomes isolated from distant ...
Boulais, Jonathan, Trost, Matthias, Landry, Christian R, Dieckmann, Régis, Levy, Emmanuel D., Soldati, Thierry, Michnick, Stephen W, Thibault, Pierre, Desjardins, Michel   +8 more
openaire   +6 more sources

Transfer of beef bacterial communities onto food-contact surfaces

Frontiers in Microbiology
IntroductionFood spoilage and pathogenic bacteria on food-contact surfaces, especially biofilm-forming strains, can transfer to meats during processing. The objectives of this study were to survey the bacterial communities of beef cuts that transfer onto
Giselle K. P. Guron, Giselle K. P. Guron, Jennifer M. Cassidy, Jennifer M. Cassidy, Chin-Yi Chen, Chin-Yi Chen, George C. Paoli, George C. Paoli   +7 more
doaj   +1 more source

ArsenazoIII functionalized gold nanoparticles: SPR based optical sensor for determination of uranyl ions (UO22+) in groundwater

Green Analytical Chemistry, 2022
Surface plasmon resonance (SPR) based spectrophotometric determination of UO22+ was carried out by arsenazoIII functionalized gold nanoparticles (AZ-AuNPs) based miniaturized detection assay in ground water samples.
Nidhi Garg, Lori Rastogi, Santanu Bera, Anand Ballal, MV Balramkrishna   +4 more
doaj   +1 more source

Comprehensive molecular characterization of pheochromocytoma and paraganglioma

Cancer Cell, 2017
Summary We report a comprehensive molecular characterization of pheochromocytomas and paragangliomas (PCC/PGLs), a rare tumor type. Multi-platform integration revealed that PCC/PGLs are driven by diverse alterations affecting multiple genes and pathways.
Lauren Fishbein, I. Leshchiner, Vonn Walter, Ludmila V. Danilova, A. G. Robertson, A. Johnson, T. Lichtenberg, Bradley A. Murray, H. Ghayee, T. Else, Shiyun Ling, S. Jefferys, Aguirre A. de Cubas, Brandon M. Wenz, E. Korpershoek, A. Amelio, L. Makowski, W. Rathmell, A. Gimenez-Roqueplo, T. Giordano, S. Asa, A. Tischler, K. Pacak, K. Nathanson, M. Wilkerson   +24 more
semanticscholar   +1 more source

Molecular Characterization of CYP2B6 Substrates [PDF]

Current Drug Metabolism, 2008
CYP2B6 has not been as fully characterized at the molecular level as other members of the human cytochrome P450 family. As more widely used in vitro probes for characterizing the involvement of this enzyme in the metabolism of xenobiotics have become available, the number of molecules identified as CYP2B6 substrates has increased. In this study we have
Sean, Ekins, Manisha, Iyer, Matthew D, Krasowski, Evan D, Kharasch   +3 more
openaire   +2 more sources