Results 131 to 140 of about 3,546,850 (294)

EP300‐Mediated MTF1‐K218 Lactylation Buffers AR‐Driven Copper Overload to Suppress Cuproptosis in Castration‐Resistant Prostate Cancer

Advanced Science, EarlyView.
Androgen receptor (AR) drives copper accumulation in prostate cancer while inducing MTF1 to buffer copper toxicity. EP300‐mediated lactylation of MTF1 at K218 promotes its nuclear translocation and metallothionein expression, sequestering cytosolic copper and preventing mitochondrial cuproptosis.
Kai Li, Yong Wei, Yongshan Li, Yuxiang Dong, Jiancheng Lv, Mingzhi Yuan, Ao Shen, Fuyang Liu, Yetao Zhang, Youjian Li, Ruixi Yu, Yang Liu, Tong Zhao, Jun Wang, Kai Zhou, Zongyao Fan, Manning Wang, Jun Xu, Mulong Du, Min Gu, Bing Yao, Qingyi Zhu   +21 more
wiley   +1 more source

High-velocity Molecular Clouds in M83

The Astrophysical Journal
High-velocity clouds (HVCs), which are gas clouds moving at high velocity relative to the galactic disk, may play a critical role in galaxy evolution, potentially supplying gas to the disk and triggering star formation.
Maki Nagata, Fumi Egusa, Fumiya Maeda, Kazuki Tokuda, Kotaro Kohno, Kana Morokuma-Matsui, Jin Koda   +6 more
doaj   +1 more source

Chemical Bond‐Orchestrated Energy Depletion to Augment Lung Cancer Chemo‐Immunotherapy

Advanced Science, EarlyView.
This study grafted dichloroacetic acid (DCA) into perylenediimide (PDI) skeleton via ionic or covalent bond to create novel metabolic agent PDIC‐AC and PDIC‐NAC, explicitly elaborated the underlying energy metabolism and therapeutic mechanism, and developed a promising strategy for energy metabolism‐targeting chemo‐immunotherapy by chemical bond ...
Xuejie Zhao, Yuting Liu, Xiao Huang, Liwen Zhao, Chunli Li, Yongwei Huang   +5 more
wiley   +1 more source

Hierarchical Dynamics within Molecular Clouds: Type 4 Scaling Relations of Molecular Clouds in the Second Galactic Quadrant

The Astrophysical Journal
We present a statistical study of the hierarchical structure of molecular clouds in the second quadrant of the Galactic midplane ( $139\mathop{.}\limits^{^\circ }75\,\leqslant \,l\,\leqslant \,159\mathop{.}\limits^{^\circ }75$ , $-5\mathop{.}\limits ...
Suziye He, Yuehui Ma, Xuepeng Chen, Hongchi Wang, Miaomiao Zhang, Zhenyi Yue, Xiangyu Ou   +6 more
doaj   +1 more source

Mechanism of Direct Acoustic Construction and Gradient Properties Tuning. [PDF]

Adv Sci (Weinh)
Directed acoustic construction enables omnidirectional gradient tuning of fingerprint‐inspired microstructures. By investigating the DAC mechanisms, diamond particles are found to enhance acoustic physical, mechanical, and chemical effects, promoting acoustic curing and broadening the range of gradient property tuning.
Wu D, Zheng L, Yao G, Liu Z, Luo L, Liang C, Wang C.   +6 more
europepmc   +2 more sources

EBV‐Driven ODC1 Upregulation Enhances Polyamine Anabolism to Promote Viral Replication and Cisplatin Resistance in Nasopharyngeal Carcinoma

Advanced Science, EarlyView.
EBV‑BZLF1 initiates ODC1‑driven polyamine anabolism that correlates with poor clinical prognosis in nasopharyngeal carcinoma. The ODC1–spermidine axis promotes viral replication, cell proliferation and innate immune evasion. Pharmacological inhibition of ODC1 rescues cisplatin sensitivity, establishing ODC1 as a viable therapeutic target for EBV ...
Yueshuo Li, Xudong Hu, Chenxing Yang, Na Liu, Lin Wang, Xi Cai, Min Tang, Ya Cao, Li Shang, Feng Shi   +9 more
wiley   +1 more source

Bioinspired Porphyrin‐Based Catalysts From Temporospatial Confined Frameworks for Ultrafast Removal of Sulfaclozine

Advanced Science, EarlyView.
We report the rational design of artificial photocatalysts with asymmetrically coordinated dual‐metal centers and a tailored microenvironment, broadly applicable strategy is established for the synthesis of multivariate zirconium‐based metal–organic frameworks, offering a platform for precisely tuning active‐site configurations to optimize ...
Yuxin Lu, Yu‐Hang Li, Zhiyi Sun, Fanke Tong, Zelin Li, Sheng Wang, Shangkun Pei, Yi Li, Xiyan Xu, Chong‐Chen Wang, Bo Wang, Xiang Li   +11 more
wiley   +1 more source

Kinematics of H I Envelopes Associated with Molecular Clouds

The Astronomical Journal
We investigate the evolution of molecular clouds through the kinematics of their atomic hydrogen (H I ) envelopes, using ^12 CO and 21 cm emission to trace the molecular and atomic gas, respectively.
Thummim Mekuria, Nia Imara
doaj   +1 more source

Gut Microbiota‐Isoallolithocholic Acid Crosstalk Promotes Calcium Oxalate Kidney Stone Formation via PARP1‐Mediated Parthanatos

Advanced Science, EarlyView.
ABSTRACT Bile acids have been implicated in calcium oxalate (CaOx) nephrolithiasis. Here, we employ multi‐omics approaches to identify isoallolithocholic acid (isoalloLCA) as the key bile acid elevated in the feces, serum, kidney, and urine of CaOx rats, confirmed by spatial metabolomics.
Zijian Zhou, Ruixi Yu, Xuan Zhou, Feng Shi, Zeyu Lin, Peng Gao, Lujia Wang, Ninghan Feng, Zhong Wu, Dawei Wang   +9 more
wiley   +1 more source

The formation of molecular clouds in spiral galaxies [PDF]

, 2007
Molecular clouds are imperative to astronomy as the sites of all known star formation. The problem of how molecular clouds are formed in spiral galaxies is approached numerically, by modelling the response of a gas disk to a spiral potential.
Dobbs, Clare L.
core   +1 more source