Results 91 to 100 of about 3,978,643 (305)

Molecular conformation of destruxin A

Tetrahedron Letters, 1989
Abstract The peptide backbone conformation of destruxin A in CDCl3, as studied by NOESY, closely resembles its crystal conformation which was deduced by a single crystal x-ray analysis.
Gupta, Sandeep, Roberts, Donald W., Renwick, J. A. A., Ni, Chao-Zhou, Clardy, Jon   +4 more
openaire   +2 more sources

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

Conformation-Dependent Monolayer and Bilayer Structures of an Alkylated TTF Derivative Revealed using STM and Molecular Modeling

In this study, the multilayer self-assembled molecular network formation of an alkylated tetrathiafulvalene compound is studied at the liquid–solid interface between 1-phenyloctane and graphite.
Andrea Minoia (1894192), Kunal S. Mali (1455109), Catarina L. Delfino (17395050), Sandra Van Aert (7547783), Yansong Hao (1396180), Cristina Martin (1698814), Elumalai Gopi (1763356), Mark Van der Auweraer (1475641), Yves Henri Geerts (1864393), Steven De Feyter (7345211), Roberto Lazzaroni (1449016)   +10 more
core   +1 more source

Conformation-dependent changes in DAT diffusion dynamics.

, 2019
Conformation-dependent changes in DAT diffusion dynamics.
Oleg Kovtun (1618660), Riley S. Ferguson (7907645), Sandra J. Rosenthal (1310463), Ian D. Tomlinson (1618675)   +3 more
core   +1 more source

On hydrodynamic methods for the analysis of the sizes and shapes of polysaccharides in dilute solution: a short review [PDF]

, 2014
Polysaccharides and their derivatives are increasingly being used by the food, cosmetic and pharmaceutical industries: physical properties like size and conformation are important contributors to their performance. Here the use of hydrodynamic tools such
Harding, Stephen E., Adams, G. G., Morris, Gordon, Morris, Gordon A., Adams, Gary G., Harding, S. E., Morris, Gordon A.; id_orcid   +6 more
core   +1 more source

The Crystal Structure of N-(1-Arylethyl)-4-methyl- 2,2-dioxo-1H-2λ⁶,1-benzothiazine-3-carboxamides as the Factor Determining Biological Activity Thereof

Scientia Pharmaceutica, 2019
In order to detect new structural and biological patterns in a series of hetaryl-3-carboxylic acid derivatives, the optically pure (S)- and (R)-enantiomers of N-(1-arylethyl)-4-methyl- 2,2-dioxo-1H-2λ6,1-benzothiazine-3-carboxamides, their true ...
Igor V. Ukrainets, Ganna M. Hamza, Anna A. Burian, Natali I. Voloshchuk, Oxana V. Malchenko, Svitlana V. Shishkina, Irina A. Danylova, Galina Sim   +7 more
doaj   +1 more source

Conversion of diarylchalcones into 4,5-dihydropyrazole-1-carbothioamides: molecular and supramolecular structures of two precursors and three products

Acta Crystallographica Section E: Crystallographic Communications, 2020
Chalcones of type 4-XC6H4C(O)CH=CHC6H4(OCH2CCH)-4, where X = Cl, Br or MeO, have been converted to the corresponding 4,5-dihydropyrazole-1-carbothioamides using a cyclocondensation reaction with thiosemicarbazide.
Mohammed A. E. Shaibah, Hemmige S. Yathirajan, Asma, Nagaraja Manju, Balakrishna Kalluraya, Ravindranath S. Rathore, Christopher Glidewell   +6 more
doaj   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source