Results 71 to 80 of about 3,781,135 (297)

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Conformation-dependent dynamics of macromolecular ions in the gas phase under an electrostatic field: A molecular dynamics simulation

, 2019
Highly charged macromolecular ions exhibit various conformations in gas. Intramolecular charge-to-charge interaction induces a transformation from a globular structure into a stretched one.
Yoshio Otani (710252), Hidenori Higashi (710247), Takaaki Orii (2739412), Mikio Kumita (710250), Tomoya Tamadate (6090473), Takafumi Seto (710251)   +5 more
core   +1 more source

On hydrodynamic methods for the analysis of the sizes and shapes of polysaccharides in dilute solution: a short review [PDF]

, 2014
Polysaccharides and their derivatives are increasingly being used by the food, cosmetic and pharmaceutical industries: physical properties like size and conformation are important contributors to their performance. Here the use of hydrodynamic tools such
Harding, Stephen E., Adams, G. G., Morris, Gordon, Morris, Gordon A., Adams, Gary G., Harding, S. E.   +5 more
core   +1 more source

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

FEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source

Global hydrodynamic analysis of the molecular flexibility of galactomannans [PDF]

, 2008
In the past, intrinsic viscosity and sedimentation velocity analyses have been used separately to assess the conformation and flexibility of guar and locust bean gum galactomannans based on worm-like chain and semi-flexible coil models.
Ortega, A., Gordon A. Morris, Ross-Murphy, S. B., Jose Garcia de la Torre, Trushar R. Patel, David R. Picout, Garcia de la Torre, J., Harding, S. E., Picout, D. R., Morris, Gordon, Simon B. Ross-Murphy, Patel, T. R., Alvaro Ortega, Stephen E. Harding   +13 more
core   +1 more source

Residual tail twisting in ascidian larvae is stabilized by asymmetric myofibrils that resist bilateral symmetry restoration

FEBS Letters, EarlyView.
Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure, Misaki K. Nishio, Satoru Okuda, Kohji Hotta   +3 more
wiley   +1 more source

Structural conformation of lipids at the oil-water interface [PDF]

, 2012
This is the accepted version of this article. The final published version can be found here: http://dx.doi.org/10.1039/C2SM26028JA neutron reflectivity study of the phospholipid 1,2-distearoyl-sn-glycero-3-phosphocholine at the hexadecane–water interface
Zarbakhsh, Ali, Webster JRP, Zarbakhsh A, Webster, JRP, Campana, Mario, Lawrence, M. Jayne, Campana, M, Lawrence MJ, Webster, John R. P., Campana M, Zarbakhsh, A, Lawrence,, MJ   +11 more
core   +1 more source

Molecular Conformation Generation via Shifting Scores [PDF]

, 2023
Molecular conformation generation, a critical aspect of computational chemistry, involves producing the three-dimensional conformer geometry for a given molecule.
Zhang, Ruimao, Yu, Tianshu, Ying, Chaolong, Liu, Ruiying, Zhou, Zihan   +4 more
core   +1 more source

Biophysical approaches for studying viral entry

FEBS Letters, EarlyView.
Viruses infect all living organisms and have been responsible for major epidemics and pandemics. Their ongoing evolutionary battle with host defenses creates a constant need for improved tools to study viral behavior. Advancing methods to probe viral attachment, fusion, and genome release deepen our understanding of how infections begin and support the
Inbar Yosibash, Raya Sorkin
wiley   +1 more source

Conformation and sequence dependent antigenic determinants in human low molecular weight kininogen

, 1983
Conformation and sequence-dependent antigenic determinants were investigated using a kinin-free low molecular weight kininogen isolated from Cohn's plasma fraction IV.
Syvänen, Ann-Christine, Kärkkäinen, T, Hamberg, U   +2 more
core   +1 more source