Results 71 to 80 of about 496,088 (311)

A glycoconjugate of Haemophilus influenzae Type b capsular polysaccharide with tetanus toxoid protein: hydrodynamic properties mainly influenced by the carbohydrate [PDF]

, 2016
Three important physical properties which may affect the performance of glycoconjugate vaccines against serious disease are molar mass (molecular weight), heterogeneity (polydispersity), and conformational flexibility in solution.
Harding, Stephen E., Conrath, K., Almuntari, F., Almutairi, Fahad M., Duvivier, Pierre, Harding, S. E., Adams, G. G., Morris, Gordon, Duvivier, P., Morris, Gordon A., Abdelhameed, Ali Saber, Adams, Gary G., Abdelhameed, A. S., Conrath, Karel, GSK Vaccines, Rue de l’Institut 89, B-1330 Rixensart, Belgium   +14 more
core   +1 more source

Mechanical control of molecular machines at an air–water interface: manipulation of molecular pliers, paddles

Science and Technology of Advanced Materials
Many artificial molecular machines have been synthesized, and various functions have been expressed by changing their molecular conformations. However, their structures are still simple compared with those of biomolecular machines, and more energy is ...
Taizo Mori
doaj   +1 more source

Crystal structures of N,N-dimethyl-(2-(2,2-diphenyl)-2-prop-2-ynyloxy)acetoxy)ethylamine and N,N-dimethyl-(2-(2,2-diphenyl)-2-prop-2-ynyloxy)acetoxy)ethylammonium 2,4,6-trinitrophenolate

Acta Crystallographica Section E: Crystallographic Communications, 2017
The N,N-dimethylethylamminium unit in N,N-dimethyl-[2-(2,2-diphenyl)-2-prop-2-ynyloxyacetoxy]ethylamine, C21H23NO3 (I), is disordered over two sets of atomic sites having occupancies of 0.880 (3) and 0.
Mohammed A. E. Shaibah, Hemmige S. Yathirajan, S. Madan Kumar, Kullaiah Byrappa, Christopher Glidewell   +4 more
doaj   +1 more source

On hydrodynamic methods for the analysis of the sizes and shapes of polysaccharides in dilute solution: a short review

, 2014
Polysaccharides and their derivatives are increasingly being used by the food, cosmetic and pharmaceutical industries: physical properties like size and conformation are important contributors to their performance. Here the use of hydrodynamic tools such
Harding, Stephen E., Adams, G. G., Morris, Gordon, Morris, Gordon A., Adams, Gary G., Harding, S. E.   +5 more
core   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Charge transport in a zinc–porphyrin single-molecule junction

Beilstein Journal of Nanotechnology, 2011
We have investigated charge transport in ZnTPPdT–Pyr (TPPdT: 5,15-di(p-thiolphenyl)-10,20-di(p-tolyl)porphyrin) molecular junctions using the lithographic mechanically controllable break-junction (MCBJ) technique at room temperature and cryogenic ...
Mickael L. Perrin, Christian A. Martin, Ferry Prins, Ahson J. Shaikh, Rienk Eelkema, Jan H. van Esch, Jan M. van Ruitenbeek, Herre S. J. van der Zant, Diana Dulić   +8 more
doaj   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Crystal structures of 2,2′-bipyridin-1-ium 1,1,3,3-tetracyano-2-ethoxyprop-2-en-1-ide and bis(2,2′-bipyridin-1-ium) 1,1,3,3-tetracyano-2-(dicyanomethylene)propane-1,3-diide

Acta Crystallographica Section E: Crystallographic Communications, 2015
In 2,2′-bipyridin-1-ium 1,1,3,3-tetracyano-2-ethoxyprop-2-en-1-ide, C10H9N2+·C9H5N4O−, (I), the ethyl group in the anion is disordered over two sets of atomic sites with occupancies 0.634 (9) and 0.366 (9), and the dihedral angle between the ring planes ...
Zouaoui Setifi, Arto Valkonen, Manuel A. Fernandes, Sami Nummelin, Habib Boughzala, Fatima Setifi, Christopher Glidewell   +6 more
doaj   +1 more source

Structural conformation of lipids at the oil-water interface

, 2012
This is the accepted version of this article. The final published version can be found here: http://dx.doi.org/10.1039/C2SM26028JA neutron reflectivity study of the phospholipid 1,2-distearoyl-sn-glycero-3-phosphocholine at the hexadecane–water interface
Zarbakhsh, Ali, Webster JRP, Zarbakhsh A, Webster, JRP, Campana, Mario, Lawrence, M. Jayne, Campana, M, Lawrence MJ, Webster, John R. P., Campana M, Zarbakhsh, A, Lawrence,, MJ   +11 more
core   +1 more source