Results 71 to 80 of about 770,458 (344)

Protein folding tames chaos [PDF]

, 2013
Protein folding produces characteristic and functional three-dimensional structures from unfolded polypeptides or disordered coils. The emergence of extraordinary complexity in the protein folding process poses astonishing challenges to theoretical ...
Wei, Guo-Wei, Xia, Kelin
core  

Alpha helix-coil phase transition: analysis of ab initio theory predictions

, 2007
In the present paper we present results of calculations obtained with the use of the theoretical method described in our preceding paper [1] and perform detail analysis of alpha helix-random coil transition in alanine polypeptides of different length. We
102, A. V. Solov'yov, A. V. Yakubovich, Becke, Chakrabartty, Fenn, Garcia, Gibbs, Go, Gomez, Gullingsrud, Hillenkamp, Humphrey, I. A. Solov'yov, Irbäck, Irbäck, Karas, Karas, Kromhout, Lednev, Lee, Lifson, Lifson, Nowak, Nymeyer, Ooi, Ooi, Phillips, Poland, Prabhu, Schellman, Scholtz, Shakhnovich, Shea, Shental-Bechor, Solov'yov, Solov'yov, Sotomayor, Thompson, Tobias, W. Greiner, Wei, Williams, Wind, Yakubovich, Yakubovich, Yakubovich, Yakubovich, Zimm   +48 more
core   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Atomistic Theory of Coherent Spin Transfer between Molecularly Bridged Quantum Dots

, 2005
Time-resolved Faradary rotation experiments have demonstrated coherent transfer of electron spin between CdSe colloidal quantum dots coupled by conjugated molecules.
Joshua Schrier, K. Birgitta Whaley, M.-H. Whangbo, P. E. Kornilovitch, R. T. Morrison, S. Datta, W. A. Harrison   +6 more
core   +1 more source

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

Mechanical control of molecular machines at an air–water interface: manipulation of molecular pliers, paddles

Science and Technology of Advanced Materials
Many artificial molecular machines have been synthesized, and various functions have been expressed by changing their molecular conformations. However, their structures are still simple compared with those of biomolecular machines, and more energy is ...
Taizo Mori
doaj   +1 more source

pH-dependent mechanism of nitric oxide release in nitrophorins 2 and 4 [PDF]

, 2009
Nitrophorins are NO carrier proteins that transport and release NO through a pH-dependent conformational change. They bind NO tightly in a low pH environment and release it in a higher pH environment.
Estrin, Dario Ariel, Marti, Marcelo Adrian, Meng, Yilin, Roitberg, Adrián, Swails, Jason M., Walker, F. Ann   +5 more
core   +1 more source

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

FEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka, Yuxi Liu, Stefano Maggi, Debnath Ghosal, Jue Wang, Prashant P. Damke, Stephen D. Carter, Wei Zhao, Sukhithasri Vijayrajratnam, Joseph P. Vogel, Carrie L. Shaffer, Grant J. Jensen   +11 more
wiley   +1 more source

Comprehensive structural model of the mechanochemical cycle of a mitotic motor highlights molecular adaptations in the kinesin family [PDF]

, 2014
Kinesins are responsible for a wide variety of microtubule-based, ATP-dependent functions. Their motor domain drives these activities but the molecular adaptations that specify these diverse and essential cellular activities are poorly understood.
Goulet, Adeline, Grossmann, S.P., Jung, Y., Major, J., Moores, Carolyn A., Rosenfeld, S.S.   +5 more
core   +3 more sources

Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions

FEBS Letters, EarlyView.
We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva, Puspa Kunwar, Md Ibnul Rifat Rahman, Joanna Koryo Kwao, Nathan Lehman, Zihan Zhang, Trenton Paul, Claire Cheng, Nicholas Truex, Hui‐Ting Lee, Jun Zhang   +10 more
wiley   +1 more source