Results 51 to 60 of about 3,978,643 (305)

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Conformation and sequence dependent antigenic determinants in human low molecular weight kininogen

, 1983
Conformation and sequence-dependent antigenic determinants were investigated using a kinin-free low molecular weight kininogen isolated from Cohn's plasma fraction IV.
Syvänen, Ann-Christine, Kärkkäinen, T, Hamberg, U   +2 more
core   +1 more source

Molecular Conformation Generation via Shifting Scores [PDF]

, 2023
Molecular conformation generation, a critical aspect of computational chemistry, involves producing the three-dimensional conformer geometry for a given molecule.
Zhang, Ruimao, Yu, Tianshu, Ying, Chaolong, Liu, Ruiying, Zhou, Zihan   +4 more
core  

Crystal structures of 2-amino-4,4,7,7-tetramethyl-4,5,6,7-tetrahydro-1,3-benzothiazol-3-ium benzoate and 2-amino-4,4,7,7-tetramethyl-4,5,6,7-tetrahydro-1,3-benzothiazol-3-ium picrate

Acta Crystallographica Section E: Crystallographic Communications, 2017
In both 2-amino-4,4,7,7-tetramethyl-4,5,6,7-tetrahydro-1,3- benzothiazol-3-ium benzoate, C11H19N2S+·C7H5O2−, (I), and 2-amino-4,4,7,7-tetramethyl-4,5,6,7-tetrahydro-1,3-benzothiazol-3-ium picrate (2,4,6-trinitrophenolate), C11H19N2S+·C6H2N3O7−, (II), the
Belakavadi K. Sagar, Marisiddaiah Girisha, Hemmige S. Yathirajan, Ravindranath S. Rathore, Christopher Glidewell   +4 more
doaj   +1 more source

Fifteen 4-(2-methoxyphenyl)piperazin-1-ium salts containing organic anions: supramolecular assembly in zero, one, two and three dimensions

Acta Crystallographica Section E: Crystallographic Communications, 2020
Fifteen 4-(2-methoxyphenyl)piperazin-1-ium salts containing organic anions have been prepared and structurally characterized. In the isostructural 4-chlorobenzoate and 4-bromobenzoate salts, C11H17N2O+·C7H4ClO2− (I) and C11H17N2O+·C7H4BrO2− (II), and the
Chayanna Harish Chinthal, Channappa N. Kavitha, Hemmige S. Yathirajan, Sabine Foro, Ravindranath S. Rathore, Christopher Glidewell   +5 more
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Conformation-dependent dynamics of macromolecular ions in the gas phase under an electrostatic field: A molecular dynamics simulation

, 2019
Highly charged macromolecular ions exhibit various conformations in gas. Intramolecular charge-to-charge interaction induces a transformation from a globular structure into a stretched one.
Yoshio Otani (710252), Hidenori Higashi (710247), Takaaki Orii (2739412), Mikio Kumita (710250), Tomoya Tamadate (6090473), Takafumi Seto (710251)   +5 more
core   +1 more source

Global hydrodynamic analysis of the molecular flexibility of galactomannans [PDF]

, 2008
In the past, intrinsic viscosity and sedimentation velocity analyses have been used separately to assess the conformation and flexibility of guar and locust bean gum galactomannans based on worm-like chain and semi-flexible coil models.
Ortega, A., Gordon A. Morris, Ross-Murphy, S. B., Jose Garcia de la Torre, Trushar R. Patel, David R. Picout, Garcia de la Torre, J., Harding, S. E., Picout, D. R., Morris, Gordon, Simon B. Ross-Murphy, Patel, T. R., Alvaro Ortega, Stephen E. Harding   +13 more
core   +1 more source

IMPACT OF TEMPERATURE ON THE STABILITY OF SILKWORM COCOON FIBERS [PDF]

Química Nova, 2019
In this study raw and processed silkworm (Bombyx mori) cocoons were investigated using confocal Raman spectroscopy in conjunction with differential scanning calorimetry (DSC) in order to examine the effect of temperature on the molecular conformation of ...
Bruno Luís Sacco, Henrique de Santana
doaj   +1 more source

Employing Molecular Conformations for Ligand-Based Virtual Screening with Equivariant Graph Neural Network and Deep Multiple Instance Learning

Molecules, 2023
Ligand-based virtual screening (LBVS) is a promising approach for rapid and low-cost screening of potentially bioactive molecules in the early stage of drug discovery.
Yaowen Gu, Jiao Li, Hongyu Kang, Bowen Zhang, Si Zheng   +4 more
doaj   +1 more source