Results 61 to 70 of about 3,781,135 (297)

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

The effect of neutral sugar distribution on the dilute solution conformation of sugar beet pectin [PDF]

, 2012
A partially degraded sugar beet pectin (C) was found to be heterogeneous in composition with neutral sugar-rich fractions of both high and low hydrodynamic radii. A neutral sugar-poor fraction was found at intermediate hydrodynamic radii.
Morris, Gordon, Ralet, M.C., Ralet, Marie-Christine, Ralet, Marie Christine, Morris, Gordon A.   +4 more
core   +1 more source

Crystal structures of 2-amino-4,4,7,7-tetramethyl-4,5,6,7-tetrahydro-1,3-benzothiazol-3-ium benzoate and 2-amino-4,4,7,7-tetramethyl-4,5,6,7-tetrahydro-1,3-benzothiazol-3-ium picrate

Acta Crystallographica Section E: Crystallographic Communications, 2017
In both 2-amino-4,4,7,7-tetramethyl-4,5,6,7-tetrahydro-1,3- benzothiazol-3-ium benzoate, C11H19N2S+·C7H5O2−, (I), and 2-amino-4,4,7,7-tetramethyl-4,5,6,7-tetrahydro-1,3-benzothiazol-3-ium picrate (2,4,6-trinitrophenolate), C11H19N2S+·C6H2N3O7−, (II), the
Belakavadi K. Sagar, Marisiddaiah Girisha, Hemmige S. Yathirajan, Ravindranath S. Rathore, Christopher Glidewell   +4 more
doaj   +1 more source

Fifteen 4-(2-methoxyphenyl)piperazin-1-ium salts containing organic anions: supramolecular assembly in zero, one, two and three dimensions

Acta Crystallographica Section E: Crystallographic Communications, 2020
Fifteen 4-(2-methoxyphenyl)piperazin-1-ium salts containing organic anions have been prepared and structurally characterized. In the isostructural 4-chlorobenzoate and 4-bromobenzoate salts, C11H17N2O+·C7H4ClO2− (I) and C11H17N2O+·C7H4BrO2− (II), and the
Chayanna Harish Chinthal, Channappa N. Kavitha, Hemmige S. Yathirajan, Sabine Foro, Ravindranath S. Rathore, Christopher Glidewell   +5 more
doaj   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Conformation-Sensitive Surface Dynamics in Thin Poly(ethylene terephthalate) Film

, 2019
The surface average conformation of poly­(ethylene terephthalate) (PET) films was modulated by adjusting the water content in corresponding trifluoroacetic acid (TFA) spin-coating solutions, which was confirmed by surface-sensitive sum frequency ...
Haosong Zhang (6458366), Jiachen Li (669381), Jianquan Xu (1529506), Xinping Wang (306022), Biao Zuo (1529497), Ophelia K. C. Tsui (1560706), Li Zhang (8200)   +6 more
core   +1 more source

Atomic resolution structure analysis of β′ polymorph crystal of a triacylglycerol: 1,2-dipalmitoyl-3-myristoyl-sn-glycerol

Journal of Lipid Research, 2001
The crystal structure of the β′-2 form of a mixed chain triacylglycerol (TAG), 1,2-dipalmitoyl-3-myristoyl-sn-glycerol (PPM), was determined to a final reliability factor of 0.074.
Kiyotaka Sato, Midori Goto, Junko Yano, Kazuhisa Honda, Dharma R. Kodali, Donald M. Small   +5 more
doaj   +1 more source

IMPACT OF TEMPERATURE ON THE STABILITY OF SILKWORM COCOON FIBERS [PDF]

Química Nova, 2019
In this study raw and processed silkworm (Bombyx mori) cocoons were investigated using confocal Raman spectroscopy in conjunction with differential scanning calorimetry (DSC) in order to examine the effect of temperature on the molecular conformation of ...
Bruno Luís Sacco, Henrique de Santana
doaj   +1 more source

Employing Molecular Conformations for Ligand-Based Virtual Screening with Equivariant Graph Neural Network and Deep Multiple Instance Learning

Molecules, 2023
Ligand-based virtual screening (LBVS) is a promising approach for rapid and low-cost screening of potentially bioactive molecules in the early stage of drug discovery.
Yaowen Gu, Jiao Li, Hongyu Kang, Bowen Zhang, Si Zheng   +4 more
doaj   +1 more source