Results 171 to 180 of about 770,458 (344)

Revealing molecular conformation-induced stress at embedded interfaces of organic optoelectronic devices by sum frequency generation spectroscopy. [PDF]

Sci Adv, 2021
Wang Z, Lin H, Zhang X, Li J, Chen X, Wang S, Gong W, Yan H, Zhao Q, Lv W, Gong X, Xiao Q, Li F, Ji D, Zhang X, Dong H, Li L, Hu W.   +17 more
europepmc   +1 more source

Activation of the West Nile virus NS3 protease: Molecular dynamics evidence for a conformational selection mechanism [PDF]

, 2009
Dariusz Ekonomiuk, Amedeo Caflisch
openalex   +1 more source

Interaction of HS1BP3 with cortactin modulates TKS5 localisation, cell secretion and cancer malignancy

Molecular Oncology, EarlyView.
Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen, Kristiane Søreng, Chiara Veroni, Laura Trachsel‐Moncho, Nagham Asp, Robin Gaupset, Lars Gustav Lyckander, Helene Knævelsrud, Lars Eftang, Anne Simonsen   +9 more
wiley   +1 more source

Revisiting Mission‐Oriented Cancer Research to tackle the increasing burden of cancer in Europe–a policy perspective

Molecular Oncology, EarlyView.
Translational cancer research and its implementation through competitively selected Comprehensive Cancer Centers across Europe should be the primary policy focus for addressing the increasing cancer burden in Europe and counteract the present main strategy to convert cancer to a chronic disease.
Manuel Heitor, Julio Celis, Ulrik Ringborg   +2 more
wiley   +1 more source

Effects of Selective Substitution of Cysteine Residues on the Conformational Properties of Chlorotoxin Explored by Molecular Dynamics Simulations

, 2018
Andrew Gregory, Leah Voit-Ostricki, Sándor Lovas, Charles R. Watts   +3 more
openalex   +2 more sources

Insights into a long life without cancer: The case of the bowhead whale

Molecular Oncology, EarlyView.
Long‐lived, large‐bodied organisms have evolved powerful anticancer mechanisms that preserve cellular and tissue integrity across extended lifespans. A recent study by Firsanov et al. shows that greater genome stability is a key factor underlying the remarkable longevity and cancer resistance of one such species, the bowhead whale.
Inés Paniagua, Johanna A. Joyce
wiley   +1 more source

Mechanically Induced Opening–Closing Action of Binaphthyl Molecular Pliers: Digital Phase Transition versus Continuous Conformational Change [PDF]

, 2016
Taizo Mori, Daisuke Ishikawa, Yusuke Yonamine, Yoshihisa Fujii, Jonathan P. Hill, Izumi Ichinose, Katsuhiko Ariga, Waka Nakanishi   +7 more
openalex   +1 more source

Molecular “Hozo”: Thermally Stable Yet Conformationally Flexible Self-Assemblies Driven by Tight Molecular Meshing [PDF]

, 2021
Yi‐Yang Zhan, Shûichi Hiraoka
openalex   +1 more source

Checkpoint blockade and the stem‐like T cell trade‐off

Molecular Oncology, EarlyView.
Stem‐like T cells are key to the success of programmed cell death protein 1 (PD1) blockade, as they sustain long‐term anti‐tumor response by continuously generating effector CD8+ T cells. However, how these cells are maintained in cancer is not fully understood. Hor et al.
Julie M. Mazet, Johanna A. Joyce
wiley   +1 more source

The molecular conformation of silk fibroin regulates osteogenic cell behavior by modulating the stability of the adsorbed protein-material interface. [PDF]

Bone Res, 2021
Long Y, Cheng X, Jansen JA, Leeuwenburgh SGC, Mao J, Yang F, Chen L.   +6 more
europepmc   +1 more source