Results 171 to 180 of about 3,978,643 (305)

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

Molecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim, Maryam Aslam, Elouise Torruella, Alphons Sony, Asif Rahman, Simira Smith, Columba de la Parra, Moira Sauane   +7 more
wiley   +1 more source

Molecular Conformation-Locking for Eye Care and Highly Efficient Narrowband Deep-Blue Organic Electroluminescence. [PDF]

Angew Chem Int Ed Engl
Cai X, Zhang B, Pu Y, Liang B, Wei J, Wang Y.   +5 more
europepmc   +1 more source

Profiling neoadjuvant therapy response in rectal cancer using meta‐analysis of publicly available transcriptomic RNA‐seq datasets

Molecular Oncology, EarlyView.
This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic, Rafael Stroggilos, Mladen Marinkovic, Ana Djuric, Suzana Stojanovic‐Rundic, Radmila Jankovic, Sergi Castellvi‐Bel, Remond J.A. Fijneman, Antonia Vlahou, Jerome Zoidakis, Milena Cavic   +10 more
wiley   +1 more source

Reversible mechanical control of molecular conformation. [PDF]

Commun Chem, 2020
Bissette AJ.
europepmc   +1 more source

The molecular conformation of silk fibroin regulates osteogenic cell behavior by modulating the stability of the adsorbed protein-material interface. [PDF]

Bone Res, 2021
Long Y, Cheng X, Jansen JA, Leeuwenburgh SGC, Mao J, Yang F, Chen L.   +6 more
europepmc   +1 more source

The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer

Molecular Oncology, EarlyView.
Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad, Silvio Carlo Ermanno Tosatto, Emanuela Leonardi   +2 more
wiley   +1 more source

Molecular conformation engineering in central 8π-electron system toward unique aggregation-induced ultra-narrowband emission with a FWHM of 13 nm. [PDF]

Light Sci Appl
Liu L, Zhang H, Xiao C, Ma B, Li B, He X, Xiao G, Zou B, Tang B, Zhang H, Lam JWY, Tang BZ, Wang Z.   +12 more
europepmc   +1 more source

Extracellular vesicle lipidomics liquid biopsy reveals systemic and tumor microenvironment metabolic reprogramming in ovarian cancer

Molecular Oncology, EarlyView.
Extracellular vesicle (EV) lipidomic profiling of plasma and ascites from patients with high‐grade serous ovarian cancer and of ovarian cancer cell lines reveals enrichment of triglycerides (TGs), diacylglycerols (DGs), phosphatidylcholine (PCs), sphingomyelins (SMs), reflecting tumor metabolic reprogramming.
Shikha Rani, Dominic Guanzon, Andrew Lai, Katherin Scholz‐Romero, Sarah Reed, Edita Ritmejeryte, Rohan Lourie, Naven Chetty, Kaltin Ferguson, Carlos Salomon   +9 more
wiley   +1 more source

Monitoring the Molecular Conformation of Individual Amphotericin B Molecules in an Aggregated State by Raman Optical Activity. [PDF]

Anal Chem
Pajor K, Zając G, Fusè M, Mach-Liszka M, Arczewska M, Gagoś M, Onaka Y, Fujisawa T, Unno M, Baranska M, Machalska E.   +10 more
europepmc   +1 more source

Exploring the Molecular Conformation Space by Soft Molecule-Surface Collision. [PDF]

J Am Chem Soc, 2020
Anggara K, Zhu Y, Delbianco M, Rauschenbach S, Abb S, Seeberger PH, Kern K.   +6 more
europepmc   +1 more source