Results 211 to 220 of about 496,088 (311)

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Understanding the AIE phenomenon of nonconjugated rhodamine derivatives via aggregation-induced molecular conformation change. [PDF]

Nat Commun
Yang LL, Wang H, Zhang J, Wu B, Li Q, Chen JY, Tang AL, Lam JWY, Zhao Z, Yang S, Tang BZ.   +10 more
europepmc   +1 more source

In situ surface-enhanced Raman spectroelectrochemistry reveals the molecular conformation of electrolyte additives in Li-ion batteries.

J Mater Chem A Mater, 2021
Zhu C, Fan C, Cortés E, Xie W.
europepmc   +1 more source

Photocrosslinked Alginate-Methacrylate Hydrogels with Modulable Mechanical Properties: Effect of the Molecular Conformation and Electron Density of the Methacrylate Reactive Group. [PDF]

Materials (Basel), 2020
Araiza-Verduzco F, Rodríguez-Velázquez E, Cruz H, Rivero IA, Acosta-Martínez DR, Pina-Luis G, Alatorre-Meda M.   +6 more
europepmc   +1 more source

The skills required for transition to university and study in biological sciences: A student perspective

FEBS Open Bio, EarlyView.
Bioscience students were asked for their opinions on the value and teaching of skills. 204 responded that teamwork, time management and study skills are necessary to reach University, that scientific writing, research, laboratory and presentation skills are taught effectively during their studies, while other skills are gained inherently through study ...
Janella Borrell, Susan Crennell
wiley   +1 more source

The effect of two formulations of carbon enterosorbents on oxidative stress indexes and molecular conformation of serum albumin in experimental animals exposed to CCl₄. [PDF]

Heliyon, 2020
Sarnatskaya V, Mikhailenko V, Prokopenko I, Gerashchenko BI, Shevchuk O, Yushko L, Glavin A, Makovetska L, Sakhno L, Sydorenko O, Kozynchenko O, Nikolaev V.   +11 more
europepmc   +1 more source

Mass spectrometry based identification of AMP‐O‐Tris generated by Thermococcus onnurineus Cas10

FEBS Open Bio, EarlyView.
Isolated Thermococcus onnurineus Cas10 generates the noncanonical ATP‐derived product AMP‐O‐Tris while in Tris‐containing buffer as identified via mass spectrometry, revealing relaxed nucleophile selectivity under isolated conditions. These findings suggest that multiprotein Csm complex assembly restricts Cas10 reactivity toward canonical cyclic ...
Su‐Jin Lee, Ga Seul Lee, JinHan Kim, Kwang‐Hyun Park, Seong‐Ryung Go, Jeong Hee Moon, Eui‐Jeon Woo   +6 more
wiley   +1 more source

Efficient Spin Interconversion by Molecular Conformation Dynamics of a Triplet Pair for Photon Up-Conversion in an Amorphous Solid. [PDF]

J Phys Chem Lett
Okamoto T, Izawa S, Hiramoto M, Kobori Y.   +3 more
europepmc   +1 more source

Conformation and molecular organization of humic acids in aqueous solutions

This diploma thesis deals with the conformation and molecular organization of humic acids in aqueous solutions. Humic substances have heterogeneous and polydisperse nature, therefore their secondary chemical structure has not yet been defined properly ...
Věžníková, Kateřina
core  

Suppression of lung adenocarcinoma migration through organelle alkalization by human lactoferrin – albumin fusion

FEBS Open Bio, EarlyView.
This paper reveals how human lactoferrin–albumin fusion (hLF‐HSA) potently suppresses lung adenocarcinoma cell migration. hLF‐HSA upregulates NHE7, leading to Golgi alkalization, disruption of the Golgi secretome, downregulation of MMP1, and reversal of EMT. These findings suggest a novel Golgi‐targeting strategy to suppress cancer cell migration.
Hana Nopia, Masahiro Kimura, Daisuke Kurimoto, Atsushi Sato   +3 more
wiley   +1 more source