Results 211 to 220 of about 770,458 (344)

Multi‐omics and low‐input proteomics profiling reveals dynamic regulation driving pluripotency initiation in early mouse embryos

FEBS Open Bio, EarlyView.
Mouse pre‐implantation development involves a transition from totipotency to pluripotency. Integrating transcriptomics, epigenetic profiling, low‐input proteomics and functional assays, we show that eight‐cell embryos retain residual totipotency features, whereas cytoskeletal remodeling regulated by the ubiquitin‐proteasome system drives progression ...
Wanqiong Li, Xi Xiao, Lingbin Qi, Chanyi Li, Sirui Song, Jiaying Qin, Zhigang Xue, Jinfeng Xue, Huaifang Li   +8 more
wiley   +1 more source

Altering the inhibitory kinetics and molecular conformation of maltase by Tangzhiqing (TZQ), a natural α-glucosidase inhibitor. [PDF]

BMC Complement Med Ther, 2020
Li Y, Zhang X, Wang R, Han L, Huang W, Shi H, Wang B, Li Z, Zou S.   +8 more
europepmc   +1 more source

Differential regulation of ZFAS1 splice variants by endoplasmic reticulum stress in hepatocyte cell lines

FEBS Open Bio, EarlyView.
ZFAS1 is a lncRNA promoting cell proliferation and migration, exhibiting high expression in various cancers. It is conserved, widely expressed, and produces multiple splice variants with unclear roles. We identified several splice variants in hepatocyte models, and found that inhibiting or suppressing regulators of the unfolded protein response (PERK ...
Sébastien Soubeyrand, Paulina Lau, Ruth McPherson   +2 more
wiley   +1 more source

Gram matrix: an efficient representation of molecular conformation and learning objective for molecular pretraining. [PDF]

Brief Bioinform
Xiang W, Zhong F, Ni L, Zheng M, Li X, Shi Q, Wang D.   +6 more
europepmc   +1 more source

Probing the Conformational Ensemble of a Bacterial Antitoxin through Molecular Dynamics Simulations and Mass Spectrometry [PDF]

, 2016
Virginia Burger, Albert Konijnenberg, Alexandra Vanderwelde, Frank Sobott, Remy Loris, Collin M. Stultz   +5 more
openalex   +1 more source

BMI‐1 modulation and trafficking during M phase in diffuse intrinsic pontine glioma

FEBS Open Bio, EarlyView.
The schematic illustrates BMI‐1 phosphorylation during M phase, which triggers its translocation from the nucleus to the cytoplasm. In cycling cells, BMI‐1 functions within the PRC1 complex to mediate H2A K119 monoubiquitination. Following PTC596‐induced M phase arrest, phosphorylated BMI‐1 dissociates from PRC1 and is exported to the cytoplasm via its
Banlanjo Umaru, Deepak Kumar Mishra, Shiva Senthil Kumar, Hao‐Han Pang, Brendan Devine, Komal Khan, Rachid Drissi   +6 more
wiley   +1 more source

Hyperconjugation-controlled molecular conformation weakens lithium-ion solvation and stabilizes lithium metal anodes. [PDF]

Chem Sci
Chen Y, Liao SL, Gong H, Zhang Z, Huang Z, Kim SC, Zhang E, Lyu H, Yu W, Lin Y, Sayavong P, Cui Y, Qin J, Bao Z.   +13 more
europepmc   +1 more source

Molecular Architecture and Conformational Flexibility of Human RNA Polymerase II [PDF]

, 2006
Seth A. Kostek, Patricia Grob, Sacha De Carlo, J. Slaton Lipscomb, Florian Garczarek, Eva Nogales   +5 more
openalex   +1 more source

Nuclear pore links Fob1‐dependent rDNA damage relocation to lifespan control

FEBS Open Bio, EarlyView.
Damaged rDNA accumulates at a specific perinuclear interface that couples nucleolar escape with nuclear envelope association. Nuclear pores at this site help inhibit Fob1‐induced rDNA instability. This spatial organization of damage handling supports a functional link between nuclear architecture, rDNA stability, and replicative lifespan in yeast.
Yamato Okada, Mina Iwaki, Kyosuke Hagiri, Rei Izumi, Masahiko Harata, Chihiro Horigome   +5 more
wiley   +1 more source

Effects of Soy Protein Isolate and Inulin Conjugate on Gel Properties and Molecular Conformation of Spanish Mackerel Myofibrillar Protein. [PDF]

Foods
Wang W, Ma S, Shao Q, Yi S.
europepmc   +1 more source