Results 21 to 30 of about 770,458 (344)

Crystal structure of 2-benzoylamino-N′-(4-hydroxybenzylidene)-3-(thiophen-2-yl)prop-2-enohydrazide

Acta Crystallographica Section E: Crystallographic Communications, 2016
In the title compound, C21H17N3O3S, the non-H atoms, apart from those in the benzoyl group, are almost coplanar (r.m.s. deviation = 0.049 Å) and the benzoyl group is almost orthogonal to the plane of the rest of the molecule [dihedral angle = 80.34 (6)°].
Karanth N. Subbulakshmi, Badiadka Narayana, Hemmige S. Yathirajan, Jerry P. Jasinski, Ravindranath S. Rathore, Christopher Glidewell   +5 more
doaj   +1 more source

Conformational control of anticancer activity: the application of arene-linked dinuclear ruthenium(II) organometallics [PDF]

, 2014
Dinuclear metal complexes have emerged as a promising class of biologically active compounds which possess unique anticancer activity. Here, we describe a novel series of arene-linked dinuclear organometallic Ru(II) complexes, where the relative ...
Dyson, Paul J., Menin, Laure, Murray, Benjamin S., Scopelliti, Rosario   +3 more
core   +2 more sources

CircRNA May Not Be “Circular”

Frontiers in Genetics, 2021
Circular RNA (circRNA) is a novel regulatory non-coding RNA and participates in diverse physiological and pathological processes. However, the structures and molecular mechanisms of circRNAs remain unclear.
Handong Sun, Zijuan Wu, Zijuan Wu, Zijuan Wu, Ming Liu, Liang Yu, Liang Yu, Jianyong Li, Jianyong Li, Jianyong Li, Jinwen Zhang, Xiangming Ding, Hui Jin, Hui Jin, Hui Jin   +14 more
doaj   +1 more source

Pathogenic mutations in the hydrophobic core of the human prion protein can promote structural instability and misfolding [PDF]

, 2010
Transmissible spongiform encephalopathies, or prion diseases, are caused by misfolding and aggregation of the prion protein PrP. These diseases can be hereditary in humans and four of the many disease-associated missense mutants of PrP are in the ...
Daggett, Valerie, van der Kamp, Marc W
core   +2 more sources

Relationship between Oversulfation and Conformation of Low and High Molecular Weight Fucoidans and Evaluation of Their in Vitro Anticancer Activity

Molecules, 2010
Low and high molecular weight fucoidans (F5-30K and F>30K) were chemically modified through the addition of sulfate groups, and the effect of oversulfation on the in vitro anticancer activity was investigated. After the addition of sulfate groups,
Myoung Lae Cho, Sang Guan You, Boo-Yong Lee   +2 more
doaj   +1 more source

Molecular flexibility of citrus pectins by combined sedimentation and viscosity analysis [PDF]

, 2007
The flexibility/rigidity of pectins plays an important part in their structure-function relationship and therefore on their commercial applications in the food and biomedical industries.
Alan Smith, Alvaro Ortega, Axelos, Bohdanecky, Braccini, Chapman, Corredig, Cros, Fishman, Gordon A. Morris, Harding, Harding, Harding, Harding, Hearst, Hearst, Huggins, Jonathan Castile, José García de al Torre, Kraemer, Kratky, Lapasin, Morris, Morris, Morris, Norziah, Noto, Pavlov, Pavlov, Perez, Picout, Pilgrim, Ralet, Ralston, Ridley, Rowe, Schuck, Schuck, Stephen E. Harding, Stockmayer, Tanford, Tombs, Van Buren, Wales, Willats, Wyatt, Yamakawa, Yoo   +47 more
core   +1 more source

Distinct Helical Molecular Orbitals through Conformational Lock** [PDF]

Chemistry – A European Journal, 2020
Abstract Several theoretical studies have proposed strategies to generate helical molecular orbitals (Hel‐MOs) in [ n ]cumulenes and oligoynes. While chiral even‐[ n ] cumulenes feature Hel‐MOs, odd‐[ n
Ozcelik A, Aranda D, GilGuerrero S, PolaOtero XA, Talavera M, Wang L, Behera SK, Gierschner J, PenaGallego A, Santoro F, PereiraCameselle R, AlonsoGomez JL   +11 more
openaire   +4 more sources

Crystal structures of (E)-1-{3-[(5-fluoro-2-hydroxybenzylidene)amino]phenyl}ethanone and of a fourth polymorph of (E)-1-{3-[(2-hydroxy-3-methoxybenzylidene)amino]phenyl}ethanone

Acta Crystallographica Section E: Crystallographic Communications, 2017
In the molecules of both (E)-1-{3-[(5-fluoro-2-hydroxybenzylidene)amino]phenyl}ethanone, C15H12FNO2, (I), and (E)-1-{3-[(2-hydroxy-3-methoxybenzylidene)amino]phenyl}ethanone, C16H15NO3, (II), which crystallizes with Z′ = 2 in space group Pca21, there are
Marisiddaiah Girisha, Hemmige S. Yathirajan, Ravindranath S. Rathore, Christopher Glidewell   +3 more
doaj   +1 more source

Order versus disorder in two isomorphous pyrazolone-substituted diethyl propanedioates prepared using a three-component one-pot reaction under solvent-free conditions

Acta Crystallographica Section E: Crystallographic Communications, 2020
Two new substituted propanedioate esters have been synthesized using a three-component solvent-free thermal reaction between diethyl propanedioate (diethyl malonate), 5-chloro-3-methyl-1-phenyl-1H-pyrazole-4-carbaldehyde and an aryl azide, forming two ...
Tharangini K. Shreekanth, Hemmige S. Yathirajan, Balakrishna Kalluraya, Sabine Foro, Christopher Glidewell   +4 more
doaj   +1 more source

Exploring the Levinthal limit in protein folding [PDF]

, 2017
According to the thermodynamic hypothesis, the native state of proteins is uniquely defined by their amino acid sequence. On the other hand, according to Levinthal, the native state is just a local minimum of the free energy and a given amino acid ...
B Fazi, B Hess, C Anfınsen, C Levinthal, C Orengo, D Baker, D Case, D van der Spoel, H Berman, H Gouda, J Sohl, JD Bryngelson, K Dill, L Cruzeiro, L Cruzeiro, L Cruzeiro, Leonor Cruzeiro, Léo Degrève, P Gettins, T Gallagher, T Lazaridis, TR Hynes, W Humphrey, W van Gunsteren   +23 more
core   +1 more source