Results 111 to 120 of about 74,344 (325)

HATS5m as an Example of GETAWAY Molecular Descriptor in Assessing the Similarity/Diversity of the Structural Features of 4-Thiazolidinone. [PDF]

Int J Mol Sci, 2022
Zapadka M, Dekowski P, Kupcewicz B.
europepmc   +1 more source

The role of histone modifications in transcription regulation upon DNA damage

FEBS Letters, EarlyView.
This review discusses the critical role of histone modifications in regulating gene expression during the DNA damage response (DDR). By modulating chromatin structure and recruiting repair factors, these post‐translational modifications fine‐tune transcriptional programmes to maintain genomic stability.
Angelina Job Kolady, Siyao Wang
wiley   +1 more source

Adaptive fuzzy partition in database mining: application to olfaction

Data Science Journal, 2006
A data set of 412 olfactory compounds, divided into animal, camphoraceous, ethereal and fatty olfaction classes, was submitted to an analysis by a Fuzzy Logic procedure called Adaptive Fuzzy Partition (AFP).This method aims to establish molecular ...
M Pintore, K Audouze, F Ros, J R Chrétien   +3 more
doaj   +1 more source

A mathematical-descriptor of tumor-mesoscopic-structure from computed-tomography images annotates prognostic- and molecular-phenotypes of epithelial ovarian cancer [PDF]

, 2019
Haonan Lu, Mubarik Arshad, Andrew Thornton, Giacomo Avesani, Paula Cunnea, Edward Curry, Fahdi Kanavati, Huan-Chang Liang, Katherine Nixon, Sophie Williams, Mohd Ali Hassan, David D.L. Bowtell, Hani Gabra, Christina Fotopoulou, Andrea Rockall, Eric O. Aboagye   +15 more
openalex   +1 more source

Molecular Descriptors, Structure Generation, and Inverse QSAR/QSPR Based on SELFIES [PDF]

, 2023
Hiromasa Kaneko
openalex   +1 more source

Integration of circadian and hypoxia signaling via non‐canonical heterodimerization

FEBS Letters, EarlyView.
CLOCK, BMAL1, and HIFs are basic helix‐loop‐helix and Per‐Arnt‐Sim domain (bHLH‐PAS) proteins, which function as transcription factors. bHLH‐PAS proteins are designated in two classes. Many class I proteins are regulated by environmental signals via their PAS domains, but such signals have not been identified for all.
Sicong Wang, Katja A. Lamia
wiley   +1 more source

Combined Machine Learning and GRID-Independent Molecular Descriptor (GRIND) Models to Probe the Activity Profiles of 5-Lipoxygenase Activating Protein Inhibitors. [PDF]

Front Pharmacol, 2022
Khan HA, Jabeen I.
europepmc   +1 more source

Substrate specificity of Burkholderia pseudomallei multidrug transporters is influenced by the hydrophilic patch in the substrate‐binding pocket

FEBS Letters, EarlyView.
Multidrug transporters BpeB and BpeF from the Gram‐negative pathogen Burkholderia pseudomallei have a hydrophilic patch in their substrate‐binding pocket. Drug susceptibility tests and growth curve analyses using an Escherichia coli recombinant expression system revealed that the hydrophilic patches of BpeB and BpeF are involved in the substrate ...
Ui Okada, Satoshi Murakami
wiley   +1 more source

Maximum Topological Distances Based Indices as Molecular Descriptors for QSPR. 4. Modeling the Enthalpy of Formation of Hydrocarbons from Elements [PDF]

, 2001
Andrés Mercader, Eduardo Castro, Andrey A. Toropov   +2 more
openalex   +1 more source

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source