Results 111 to 120 of about 34,759 (340)
A paradigmatic approach to the molecular descriptor computation for some antiviral drugs. [PDF]
Heliyon, 2023 Ghani MU +5 more
europepmc +1 more source
The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes
FEBS Letters, EarlyView.Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga +3 more
wiley +1 more source
Why is the dual descriptor a more accurate local reactivity descriptor than Fukui functions?
, 2014 A mathematical analysis reveals that dual descriptor is a more accurate tool than nucleophilic and electrophilic Fukui functions. Although Fukui function has the capability of revealing nucleophilic and electrophilic regions on a molecule, the dual ...
Martínez-Araya J.I.
core +1 more source
Maximum Topological Distances Based Indices as Molecular Descriptors for QSPR. 4. Modeling the Enthalpy of Formation of Hydrocarbons from Elements [PDF]
, 2001 Andrés Mercader +2 more
openalex +1 more source
FEBS Letters, EarlyView.Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley +1 more source
Hydration Free Energy as a Molecular Descriptor in Drug Design: A Feasibility Study
, 2016 In this work the idea was investigated whether calculated hydration energy (ΔGhyd) can be used as a molecular descriptor in defining promising regions of chemical space for drug design.
Reynisson, Jóhannes, Zafar, Ayesha
core +1 more source
FEBS Letters, EarlyView.Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil +4 more
wiley +1 more source
Molecular Descriptors (Transform Descriptors) and Reactivity Prediction: Is it Possible?
, 2021 Introduction to a novel methodology for the prediction of chemical reactivity. Though under development, the methodology presented allows an easy understanding on how predictions in organic synthetic chemistry operate.
openaire +1 more source
pH‐mediated activation of the lysosomal arginine sensor SLC38A9
FEBS Letters, EarlyView.Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley +1 more source
Vision-based Navigation Using Landmark Recognition for Unmanned Aerial Vehicles [PDF]
, 2014 This thesis describes a new approach for a vision-based positioning system for Un- manned Aerial Vehicles using a recognition method based on known, robust geo- graphic landmarks.
Mannberg, Mikael
core