Results 91 to 100 of about 6,685,576 (314)

Use of the MLPA Assay in the Molecular Diagnosis of Gene Copy Number Alterations in Human Genetic Diseases

, 2012
Multiplex Ligation-dependent Probe Amplification (MLPA) assay is a recently developed technique able to evidence variations in the copy number of several human genes.
Valentina Gatta, Liborio Stuppia, Giandomenico Palka, Ivana Antonucci   +3 more
core   +1 more source

Partial FAK suppression promotes tumor growth, an effect reversed by macrophage p110δ PI3K inactivation

Molecular Oncology, EarlyView.
Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou, Niki Tzenaki, Anna Tsapara, Maria Tzardi, Evangelia A. Papakonstanti   +4 more
wiley   +1 more source

Clinical Characteristics and Machine Learning-Based Severity Classification of Chlamydia psittaci Pneumonia: A Retrospective Cohort Study

Infection and Drug Resistance
Xiao Lei,1– 3,* Liyuan Zhao,1– 3,* Ziwei Zhong,1– 3,* Haiyan Lin,1– 3 Zhiting Xie,1– 3 Yaping Guo,1– 3 Sufeng Zhang,1– 4 Chengsheng Zhang,1– 3 Tian Gong1– 31Center for Molecular Diagnosis and Precision Medicine, The First ...
Lei X, Zhao L, Zhong Z, Lin H, Xie Z, Guo Y, Zhang S, Zhang C, Gong T   +8 more
doaj  

Utility of four machine learning approaches for identifying ulcerative colitis and Crohn's disease

Heliyon
Objective: Peripheral blood routine parameters (PBRPs) are simple and easily acquired markers to identify ulcerative colitis (UC) and Crohn's disease (CD) and reveal the severity, whereas the diagnostic performance of individual PBRP is limited.
Jingwen Pei, Guobing Wang, Yi Li, Lan Li, Chang Li, Yu Wu, Jinbo Liu, Gang Tian   +7 more
doaj   +1 more source

Can Statin Treatment Reduce the Risk of Hepatocellular Carcinoma? A Systematic Review and Meta-Analysis

Technology in Cancer Research & Treatment, 2020
Background: Whether statins can reduce the incidence of cancers has been an interesting topic in recent years. This meta-analysis aimed to determine the relationship between statin treatment with the risk of hepatocellular carcinoma.
Yue Chang MM, Qinyu Liu MM, Zidong Zhou MM, Yuping Ding MD, Mei Yang MM, Wei Xu MD, Kai Chen MM, Qing Zhang MM, Zhenguo Wang MM, Hai Li MD   +9 more
doaj   +1 more source

Profiling neoadjuvant therapy response in rectal cancer using meta‐analysis of publicly available transcriptomic RNA‐seq datasets

Molecular Oncology, EarlyView.
This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic, Rafael Stroggilos, Mladen Marinkovic, Ana Djuric, Suzana Stojanovic‐Rundic, Radmila Jankovic, Sergi Castellvi‐Bel, Remond J.A. Fijneman, Antonia Vlahou, Jerome Zoidakis, Milena Cavic   +10 more
wiley   +1 more source

NIR-IIb fluorescence antiangiogenesis copper nano-reaper for enhanced synergistic cancer therapy

Journal of Nanobiotechnology
The formation of blood vessel system under a relatively higher Cu2+ ion level is an indispensable precondition for tumor proliferation and migration, which was assisted in forming the tumor immune microenvironment.
Wenling Li, Huan Xin, Wenjuan Gao, Pengjun Yuan, Feixue Ni, Jingyi Ma, Jingrui Sun, Jianmin Xiao, Geng Tian, Lu Liu, Guilong Zhang   +10 more
doaj   +1 more source

Enhancement of blaIMP-carrying plasmid transfer in Klebsiella pneumoniae by hospital wastewater: a transcriptomic study

Frontiers in Microbiology
IntroductionKlebsiella pneumoniae is a critical ESKAPE pathogen that presents a significant challenge to public health because of its multidrug-resistant strains.
Yuan Jiang, Luting Shu, Huan Wen, Huan Wen, Yueshuai Wei, Siyi Liu, Caihong Ye, Ling Cheng, Zhangrui Zeng, Jinbo Liu   +9 more
doaj   +1 more source

Extracellular vesicle lipidomics liquid biopsy reveals systemic and tumor microenvironment metabolic reprogramming in ovarian cancer

Molecular Oncology, EarlyView.
Extracellular vesicle (EV) lipidomic profiling of plasma and ascites from patients with high‐grade serous ovarian cancer and of ovarian cancer cell lines reveals enrichment of triglycerides (TGs), diacylglycerols (DGs), phosphatidylcholine (PCs), sphingomyelins (SMs), reflecting tumor metabolic reprogramming.
Shikha Rani, Dominic Guanzon, Andrew Lai, Katherin Scholz‐Romero, Sarah Reed, Edita Ritmejeryte, Rohan Lourie, Naven Chetty, Kaltin Ferguson, Carlos Salomon   +9 more
wiley   +1 more source

Carrier frequencies, trends, and geographical distribution of hearing loss variants in China: The pooled analysis of 2,161,984 newborns

Heliyon
Objective: The aim of this study is to comprehensively investigate the prevalence and distribution patterns of three common genetic variants associated with hearing loss (HL) in Chinese neonatal population.
Jia Feng, Zhangrui Zeng, Sijian Luo, Xuexue Liu, Qing Luo, Kui Yang, Guanbin Zhang, Jinbo Liu   +7 more
doaj   +1 more source