Results 71 to 80 of about 6,685,576 (314)

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

International Society for Prenatal Diagnosis 2024 Debate 3—Cytogenetics Is a Dinosaur and Should Be Replaced by Molecular Technologies

Cytogenetic technologies such as G-banding chromosome and FISH analyses have long been the gold standard diagnostic test in prenatal genetic testing. However, unbiased next-generation sequencing technologies such as fetal exome or genome sequencing (ES ...
Akkari, Yassmine M. N., Breman, Amy M., Talkowski, Michael E.   +2 more
core   +1 more source

Molecular diagnosis of pediatric tumors

, 2017
<p>Pediatric tumors are challenging in the context of best diagnosis, treatment, and prognosis. For tumors which have a genetic association or a cancer predisposition syndrome, the prognosis depends on accurate diagnosis.
Tanushri Mukherjee, Rajat Dutta, Soma Mukherjee   +2 more
core   +1 more source

Flow Enabled Target Capture Halbach‐based magnetic enrichment increases circulating tumor cell capture from blood in metastatic cancer patients

Molecular Oncology, EarlyView.
Pair‐wise comparison of the CellSearch and FETCH enrichment technologies for circulating tumor cells (CTCs) from metastatic breast, prostate, and small cell lung cancer patients shows an increased capture of CTCs using FETCH enrichment. The clinical implementation of circulating tumor cells (CTCs) as a predictive tool for therapy efficacy in the ...
Michiel Stevens, Anouk Mentink, Tom Niessink, Frank Coumans, Leonie Mekenkamp, Ruchi Bansal, Jeroen Hiltermann   +6 more
wiley   +1 more source

Male papillomavirus infection and genotyping in the Qingyuan area

Virology Journal, 2020
Background This study aims to screen the male human papillomavirus (HPV) infection status and genotyping in Qingcheng District, Qingyuan City, Guangdong Province, China to provide a reference basis for formulating prevention strategies for HPV infection.
Wei-Guo Yin, Meng Yang, Lei Peng, Yan-Mei Liu, Bin Cheng, Shu-Xia Xuan, Chen Chen, Feng-Jun Tan   +7 more
doaj   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

Pan-cancer association of a mitochondrial function score with genomic alterations and clinical outcome

Scientific Reports
Mitochondria are pivotal in cellular energy metabolism and have garnered significant attention for their roles in cancer progression and therapy resistance.
Shikun Zhu, Chen Chen, Min Wang, Yue Liu, Baolin Li, Xing Qi, Miao Song, Xuexue Liu, Jia Feng, Jinbo Liu   +9 more
doaj   +1 more source

Immunomodulatory therapy for sepsis: from pathophysiological mechanisms to precision treatment

Frontiers in Cellular and Infection Microbiology
Sepsis is a life-threatening syndrome marked by immune dysregulation, progressing from hyperinflammation to immunosuppression. The translation of immunomodulatory therapies has been hampered by the disease’s extreme heterogeneity. This review synthesizes
Yiting Xiao, Yiting Xiao, Yiting Xiao, Liyun Xu, Liyun Xu, Liyun Xu, Yuan Jiang, Yuan Jiang, Yuan Jiang, Qian Wang, Qian Wang, Qian Wang, Jie Deng, Jie Deng, Jie Deng, Zixiang Luo, Zixiang Luo, Zixiang Luo, Wenchao Xie, Wenchao Xie, Wenchao Xie, Caihong Ye, Caihong Ye, Caihong Ye, Zhangrui Zeng, Zhangrui Zeng, Zhangrui Zeng   +26 more
doaj   +1 more source

Molecular neuropathology of gliomas

, 2009
Gliomas are the most common primary human brain tumors. They comprise a heterogeneous group of benign and malignant neoplasms that are histologically classified according to the World Health Organization (WHO) classification of tumors of the nervous ...
Markus Riemenschneider, Riemenschneider, Markus J., Reifenberger, Guido, Guido Reifenberger   +3 more
core   +1 more source