Results 71 to 80 of about 6,296,126 (310)

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

Molecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera, Laura Vela‐Martín, Pablo Fernández‐Navarro, José Luis López‐Lorenzo, Javier Cornago, Pilar Llamas, Eduardo Pérez‐Gómez, José Luis Marín‐Rubio, Manuel Fresno, Javier Santos, José Fernández‐Piqueras, María Villa‐Morales   +11 more
wiley   +1 more source

Pan-cancer association of a mitochondrial function score with genomic alterations and clinical outcome

Scientific Reports
Mitochondria are pivotal in cellular energy metabolism and have garnered significant attention for their roles in cancer progression and therapy resistance.
Shikun Zhu, Chen Chen, Min Wang, Yue Liu, Baolin Li, Xing Qi, Miao Song, Xuexue Liu, Jia Feng, Jinbo Liu   +9 more
doaj   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Clinical Advances in Molecular Biomarkers for Cancer Diagnosis and Therapy

, 2013
Cancer diagnosis is currently undergoing a paradigm shift with the incorporation of molecular biomarkers as part of routine diagnostic panel. The molecular alteration ranges from those involving the DNA, RNA, microRNAs (miRNAs) and proteins.
Philip Philip, Seema Sethi, Shadan Ali, Fazlul Sarkar   +3 more
core   +1 more source

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

Molecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner, Pierre Tennstedt, Randi C. Pose, Christian Müller, Katharina Besler, Svenja Schneegans, Malik Alawi, Marie C. Roesch, Sven Peine, Desiree Bonci, Joanna Budna‐Tukan, Evi Lianidou, Catherine Alix‐Panabières, Derya Tilki, Klaus Pantel   +14 more
wiley   +1 more source

Development of CYP21A2 genotyping assay for the diagnosis of congenital adrenal hyperplasia

, 2021
Steroid 21-hydroxylase deficiency due to CYP21A2 gene mutations represents more than 90% of all congenital adrenal hyperplasia cases. This deficiency is screened by measuring levels of 17-hydroxyprogesterone, which may vary, causing false positive or ...
Rispoli, Thaiane, Grandi, Tarciana, Mello, Maricilda Palandi de, Castro, Simone Martins de, Silva, Cláudia Maria Dornelles da, Kopacek, Cristiane, Prado, Mayara Jorgens, Rossetti, Maria Lucia Rosa   +7 more
core   +1 more source

Multilayer analysis of ethnically diverse blood and urine biomarkers for breast cancer risk and prognosis

Scientific Reports
Breast cancer (BC) is one of the most common malignancies among women globally, characterized by complex pathogenesis involving various biomarkers present in blood and urine.
Jia Feng, Xing Qi, Chen Chen, Baolin Li, Min Wang, Xuelong Xie, Kailan Yang, Xuan Liu, Rui min Chen, Tongtong Guo, Jinbo Liu   +10 more
doaj   +1 more source

Clinical and molecular characteristics, antibiotic susceptibility, risk factors and predictors of mortality in carbapenem-resistant klebsiella pneumoniae bloodstream infections in Southern Sichuan, China: a 5-year multicenter study

Frontiers in Cellular and Infection Microbiology
BackgroundThe World Health Organization (WHO) has listed carbapenem-resistant Klebsiella pneumoniae (CRKP) as one of the key pathogens that require the highest priority for containment.
Wenchao Xie, Wenchao Xie, Wenchao Xie, Zixiang Luo, Zixiang Luo, Zixiang Luo, Chenghong Gu, yanzhi Li, yanzhi Li, yanzhi Li, Jie Deng, Jie Deng, Jie Deng, Yuling Yang, Yueshuai Wei, Yueshuai Wei, Yueshuai Wei, Yuan Jiang, Yuan Jiang, Yuan Jiang, Jinbo Liu, Jinbo Liu, Jinbo Liu, Zhangrui Zeng, Zhangrui Zeng, Zhangrui Zeng   +25 more
doaj   +1 more source

Flow Enabled Target Capture Halbach‐based magnetic enrichment increases circulating tumor cell capture from blood in metastatic cancer patients

Molecular Oncology, EarlyView.
Pair‐wise comparison of the CellSearch and FETCH enrichment technologies for circulating tumor cells (CTCs) from metastatic breast, prostate, and small cell lung cancer patients shows an increased capture of CTCs using FETCH enrichment. The clinical implementation of circulating tumor cells (CTCs) as a predictive tool for therapy efficacy in the ...
Michiel Stevens, Anouk Mentink, Tom Niessink, Frank Coumans, Leonie Mekenkamp, Ruchi Bansal, Jeroen Hiltermann   +6 more
wiley   +1 more source

Prenatal Diagnosis [PDF]

, 2012
This book provides detailed and comprehensive coverage on various aspects of prenatal diagnosis-with particular emphasis on sonographic and molecular diagnostic issues.

core   +2 more sources