Results 51 to 60 of about 1,017,559 (266)

Natural Killer Cells in Paediatric Soft Tissue Sarcomas: A Systematic Review

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Paediatric soft tissue sarcomas (pSTS) are a rare and heterogeneous group of malignant tumours arising in tissues of mesenchymal origin. The role of natural killer (NK) cells in pSTS remains poorly understood, with evidence fragmented across small preclinical studies and early‐phase clinical trials.
Raya Dean, Lara V. Graham, Christina Putnam, Rosa Gomes Alves Martins, Daniel T. Harding, Tim J. Underwood, Zoë S. Walters, Matthew D. Blunt   +7 more
wiley   +1 more source

The Role of Chemotherapy in Pediatric Myoepithelial Carcinoma: A Systematic Review of the Literature

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Myoepithelial carcinoma (MEC) in pediatric patients is a rare and aggressive malignancy characterized by heterogeneous morphology and variable molecular features. The optimal role of chemotherapy remains unclear. We conducted a systematic review according to PRISMA 2020 guidelines to evaluate chemotherapy in pediatric and young‐adult patients ...
Marco Salvi, Maria Carmen Affinita, Giulia Fichera, Luisa Santoro, Angela Scagnellato, Calogero Virgone, Elena Poli, Gianni Bisogno   +7 more
wiley   +1 more source

Multilayer analysis of ethnically diverse blood and urine biomarkers for breast cancer risk and prognosis

Scientific Reports
Breast cancer (BC) is one of the most common malignancies among women globally, characterized by complex pathogenesis involving various biomarkers present in blood and urine.
Jia Feng, Xing Qi, Chen Chen, Baolin Li, Min Wang, Xuelong Xie, Kailan Yang, Xuan Liu, Rui min Chen, Tongtong Guo, Jinbo Liu   +10 more
doaj   +1 more source

Clinical and molecular characteristics, antibiotic susceptibility, risk factors and predictors of mortality in carbapenem-resistant klebsiella pneumoniae bloodstream infections in Southern Sichuan, China: a 5-year multicenter study

Frontiers in Cellular and Infection Microbiology
BackgroundThe World Health Organization (WHO) has listed carbapenem-resistant Klebsiella pneumoniae (CRKP) as one of the key pathogens that require the highest priority for containment.
Wenchao Xie, Wenchao Xie, Wenchao Xie, Zixiang Luo, Zixiang Luo, Zixiang Luo, Chenghong Gu, yanzhi Li, yanzhi Li, yanzhi Li, Jie Deng, Jie Deng, Jie Deng, Yuling Yang, Yueshuai Wei, Yueshuai Wei, Yueshuai Wei, Yuan Jiang, Yuan Jiang, Yuan Jiang, Jinbo Liu, Jinbo Liu, Jinbo Liu, Zhangrui Zeng, Zhangrui Zeng, Zhangrui Zeng   +25 more
doaj   +1 more source

Nephrogenic Rests/Nephroblastomatosis in Patients With Unilateral Wilms Tumor Are Not Associated With an Increased Risk of Relapse: An Analysis of Patients Treated on the SIOP‐WT‐2001 Protocol in the SIOP‐UK‐CCLG and SIOP‐GPOH Studies (2001–2022)

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Introduction Nephrogenic rests (NRs) and nephroblastomatosis (NBM) are precursor lesions for development of Wilms tumor (WT). Their association with the risk of relapse has not been properly assessed, partly due to misunderstanding of their diagnostic criteria and terminology.
Gordan M. Vujanić, Rhoikos Furtwängler, Tanzina Chowdhury, Christian Vokuhl, Jenny Wegert, Norbert Graf   +5 more
wiley   +1 more source

Genetic analyses identify circulating genes related to brain structures associated with Parkinson’s disease

npj Parkinson's Disease
Magnetic resonance imaging and circulating molecular testing are potential methods for diagnosing and treating Parkinson’s disease (PD). However, their relationships remain insufficiently studied.
Zhe Han, Yanping Zhu, Zhenhong Xia, Qing Deng, Hongjie He, Quanting Yin, Hui Zhang, Mudan Yuan, Chunhua Yang, Geng Tian, Jia Mi, Fuyi Xu   +11 more
doaj   +1 more source

Immunomodulatory therapy for sepsis: from pathophysiological mechanisms to precision treatment

Frontiers in Cellular and Infection Microbiology
Sepsis is a life-threatening syndrome marked by immune dysregulation, progressing from hyperinflammation to immunosuppression. The translation of immunomodulatory therapies has been hampered by the disease’s extreme heterogeneity. This review synthesizes
Yiting Xiao, Yiting Xiao, Yiting Xiao, Liyun Xu, Liyun Xu, Liyun Xu, Yuan Jiang, Yuan Jiang, Yuan Jiang, Qian Wang, Qian Wang, Qian Wang, Jie Deng, Jie Deng, Jie Deng, Zixiang Luo, Zixiang Luo, Zixiang Luo, Wenchao Xie, Wenchao Xie, Wenchao Xie, Caihong Ye, Caihong Ye, Caihong Ye, Zhangrui Zeng, Zhangrui Zeng, Zhangrui Zeng   +26 more
doaj   +1 more source

Time to Diagnosis Among Children and Adolescents With Cancer in Québec, Canada: A Population‐Based Study

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Timely cancer diagnosis in children and adolescents is important to improving outcomes. We aimed to quantify time to diagnosis and assess variations by patient, demographic and system‐level factors. Procedure We conducted a population‐based study of individuals aged 0–19 years diagnosed with one of 12 cancers from 2010 to 2022 in ...
Callum Mullen, Ronald D. Barr, Erin Strumpf, Mariam El‐Zein, Eduardo L. Franco, Talía Malagón   +5 more
wiley   +1 more source

Comparative Evaluation of Hemodiafiltration, Hemoperfusion, and Standard Hemodialysis on Efficacy, Inflammatory Control, Dialysis Adequacy, and Safety in End‐Stage Renal Disease: A Prospective Observational Study

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Background Chronic micro‐inflammation in patients with end‐stage renal disease (ESRD) is a significant driver of cardiovascular complications and diminished quality of life. While standard hemodialysis (SHD) effectively manages small‐molecule clearance, its ability to remove medium‐to‐large uremic toxins—the primary catalysts of systemic ...
Hongwei Zuo, Weisi Dai, Jie Mao, Mei Ye, Xingshan Lu, Xiaocui Zhang   +5 more
wiley   +1 more source

Development of a Recombinant Outer Membrane Vesicles (OMVs)‐Based Vaccine Against Helicobacter pylori Infection in Mice

Journal of Extracellular Vesicles
The current vaccine development for Helicobacter pylori (H. pylori) still faces challenges of weak immune responses stimulated by existing antigens and a lack of safe adjuvants. The modification of the lipopolysaccharide (LPS) structure by H.
Qiong Liu, Biaoxian Li, Jinrong Ma, Xiao Lei, Junpeng Ma, Yanyan Da, Zhiyong Zhou, Jiaqi Tao, Xinyi Ren, Ting Zeng, Zhiting Xie, Haiyan Lin, Zihui Jin, Yi Wan, Liang Zhang, Donglin Lai, Yaping Guo, Jing Li, Yinpan Shang, Lu Shen, Ziwei Tao, Tian Gong, Chengsheng Zhang   +22 more
doaj   +1 more source