Results 61 to 70 of about 1,017,559 (266)

Utility of four machine learning approaches for identifying ulcerative colitis and Crohn's disease

Heliyon
Objective: Peripheral blood routine parameters (PBRPs) are simple and easily acquired markers to identify ulcerative colitis (UC) and Crohn's disease (CD) and reveal the severity, whereas the diagnostic performance of individual PBRP is limited.
Jingwen Pei, Guobing Wang, Yi Li, Lan Li, Chang Li, Yu Wu, Jinbo Liu, Gang Tian   +7 more
doaj   +1 more source

Molecular diagnosis of phytoplasmas.

Phytopathologia Mediterranea, 2003
Phytoplasmas are wall-less prokaryotes associated with diseases in numerous plant species worldwide. In nature they are transmitted by phloem-sucking insects. Yellowing, decline, witches’ broom, leaf curl, floral virescence and phyllody are the most conspicuous symptoms associated with phytoplasmas, although infections are sometimes asymptomatic. Since
openaire   +5 more sources

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

NIR-IIb fluorescence antiangiogenesis copper nano-reaper for enhanced synergistic cancer therapy

Journal of Nanobiotechnology
The formation of blood vessel system under a relatively higher Cu2+ ion level is an indispensable precondition for tumor proliferation and migration, which was assisted in forming the tumor immune microenvironment.
Wenling Li, Huan Xin, Wenjuan Gao, Pengjun Yuan, Feixue Ni, Jingyi Ma, Jingrui Sun, Jianmin Xiao, Geng Tian, Lu Liu, Guilong Zhang   +10 more
doaj   +1 more source

Enhancement of blaIMP-carrying plasmid transfer in Klebsiella pneumoniae by hospital wastewater: a transcriptomic study

Frontiers in Microbiology
IntroductionKlebsiella pneumoniae is a critical ESKAPE pathogen that presents a significant challenge to public health because of its multidrug-resistant strains.
Yuan Jiang, Luting Shu, Huan Wen, Huan Wen, Yueshuai Wei, Siyi Liu, Caihong Ye, Ling Cheng, Zhangrui Zeng, Jinbo Liu   +9 more
doaj   +1 more source

Can Statin Treatment Reduce the Risk of Hepatocellular Carcinoma? A Systematic Review and Meta-Analysis

Technology in Cancer Research & Treatment, 2020
Background: Whether statins can reduce the incidence of cancers has been an interesting topic in recent years. This meta-analysis aimed to determine the relationship between statin treatment with the risk of hepatocellular carcinoma.
Yue Chang MM, Qinyu Liu MM, Zidong Zhou MM, Yuping Ding MD, Mei Yang MM, Wei Xu MD, Kai Chen MM, Qing Zhang MM, Zhenguo Wang MM, Hai Li MD   +9 more
doaj   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

p53-inducible lncRNA LOC644656 causes genotoxic stress-induced stem cell maldifferentiation and cancer chemoresistance

Nature Communications
Genotoxic stress-induced stem cell maldifferentiation (GSMD) integrates DNA damage responses with loss of stemness and lineage-specific differentiation to prevent damaged stem cell propagation. However, molecular mechanisms governing GSMD remain unclear.
Ai Tamura, Kazuyuki Yamagata, Takashi Kono, Masanori Fujimoto, Takahiro Fuchigami, Motoi Nishimura, Masataka Yokoyama, Akitoshi Nakayama, Naoko Hashimoto, Ikki Sakuma, Nobuyuki Mitsukawa, Yusuke Kawashima, Osamu Ohara, Shinichiro Motohashi, Eiryo Kawakami, Takashi Miki, Atsushi Onodera, Tomoaki Tanaka   +17 more
doaj   +1 more source