Results 61 to 70 of about 6,296,126 (310)

Research progress and application status of organoid in breast cancer subtypes

Biomolecules & Biomedicine
Breast cancer (BC) is a prevalent malignant tumor that poses a significant health risk to women. The complexity of basic BC research and clinical treatment is influenced by multiple factors, including age, fertility, hormone metabolism, molecular ...
Qiuxia Zhang, Min Wang, Li You, Chen Chen, Jia Feng, Miao Song, Kui Yang, Xuexue Liu, Guangrong Li, Jinbo Liu   +9 more
doaj   +1 more source

Metastatic niche shaped by host factors influences disseminated cancer cell fate

FEBS Letters, EarlyView.
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward, Álvaro Ruiz‐Tabas, Patricia Altea‐Manzano   +2 more
wiley   +1 more source

Molecular Diagnosis of Burkitt's Lymphoma

New England Journal of Medicine, 2006
The distinction between Burkitt's lymphoma and diffuse large-B-cell lymphoma is crucial because these two types of lymphoma require different treatments. We examined whether gene-expression profiling could reliably distinguish Burkitt's lymphoma from diffuse large-B-cell lymphoma.Tumor-biopsy specimens from 303 patients with aggressive lymphomas were ...
Dave, Sandeep S., Fu, Kai, Wright, George W., Lam, Lloyd T., Kluin, Philip, Boerma, Evert-Jan, Greiner, Timothy, Weisenburger, Dennis D., Rosenwald, Andreas, Ott, German, Müller-Hermelink, Hans-Konrad, Gascoyne, Randy D., Delabie, Jan, Rimsza, Lisa M., Braziel, Rita M., Grogan, Thomas M., Campo, Elias, Jaffe, Elaine S., Dave, Bhavana J., Sanger, Warren, Bast, M, Vose, Julie M., Armitage, James O., Connors, Joseph M., Smeland, Erlend B., Kvaloy, Stein, Holte, Harald, Fisher, Richard I., Miller, Thomas P., Montserrat, Emilio, Wilson, Wyndham H., Bahl, Manisha, Zhao, Hong, Yang, Liming, Powell, John, Simon, Richard, Chan, Wing C., Staudt, Louis M.   +37 more
openaire   +5 more sources

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

Malaria "diagnosis" and diagnostics in Afghanistan. [PDF]

, 2012
In many malaria-endemic areas, including Afghanistan, overdiagnosis of malaria is common. Even when using parasite-based diagnostic tests prior to treatment, clinicians commonly prescribe antimalarial treatment following negative test results.
Rowland, Mark, Wood, Molly, Kizito, James, Mayan, Ismail, Reynolds, Joanna, Mikhail, Amy, Ahmad, Tamanna, Motahed, Mohibullah, Anwari, Nadia, Karimullah, Karimullah, Baktash, Sayed Habib, Leslie, Toby, Chandler, Clare, Hazansai, Anwar   +13 more
core   +1 more source

Orofacial Pain: Molecular Mechanisms, Diagnosis, and Treatment 2021

, 2022
The Special Issue “Orofacial Pain: Molecular Mechanisms, Diagnosis, and Treatment 2021” contains 6 articles published by 41 authors from different countries focusing on nucleus accumbens core GABAergic neurons, receptor-interacting serine/threonine ...
Matsuka, Yoshizo, Yoshizo Matsuka
core   +1 more source

Development of metachronous rectal cancers in a young man with dyskeratosis congenita: a case report

Journal of Medical Case Reports, 2019
Background DKC1 (dyskerin pseudouridine synthase 1) is a causative gene for X-linked dyskeratosis congenita. Approximately 8% of patients with dyskeratosis congenita have malignancy, but information about the development of malignancy in patients with ...
Motoko Watanabe, Gou Yamamoto, Kenji Fujiyoshi, Yoshito Akagi, Miho Kakuta, Yoji Nishimura, Kiwamu Akagi   +6 more
doaj   +1 more source

Male papillomavirus infection and genotyping in the Qingyuan area

Virology Journal, 2020
Background This study aims to screen the male human papillomavirus (HPV) infection status and genotyping in Qingcheng District, Qingyuan City, Guangdong Province, China to provide a reference basis for formulating prevention strategies for HPV infection.
Wei-Guo Yin, Meng Yang, Lei Peng, Yan-Mei Liu, Bin Cheng, Shu-Xia Xuan, Chen Chen, Feng-Jun Tan   +7 more
doaj   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

International Society for Prenatal Diagnosis 2024 Debate 3—Cytogenetics Is a Dinosaur and Should Be Replaced by Molecular Technologies

Cytogenetic technologies such as G-banding chromosome and FISH analyses have long been the gold standard diagnostic test in prenatal genetic testing. However, unbiased next-generation sequencing technologies such as fetal exome or genome sequencing (ES ...
Akkari, Yassmine M. N., Breman, Amy M., Talkowski, Michael E.   +2 more
core   +1 more source