Results 131 to 140 of about 6,296,126 (310)

Optical imaging for brown or beige adipose tissue

View
Currently, one in three adults worldwide may be obese or overweight. Obesity is characterized by an excess of energy‐storing white fat. An ingenious and sought‐after strategy against obesity is to activate energy‐consuming beige fat, which is converted ...
Jiamin Liu, Linjie Ni, Minmin Peng, Yiying Liang, Chan Lu, Hanying Zheng, Zicheng Huang, Jinde Zhang, Ronghe Chen   +8 more
doaj   +1 more source

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

FEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill, Yelyzaveta Pulnova, Elke De Zitter, Helen M. Ginn, Briony A. Yorke   +4 more
wiley   +1 more source

Molecular Diagnosis, Clinical Trial Representation, and Precision Medicine in Minority Patients with Oncogene-Driven Lung Cancer

Lung cancer remains the leading cause of cancer-related death in the US and worldwide. Recent advances in molecular profiling and targeted therapies have revolutionized the management of non-small cell lung cancer (NSCLC), particularly in oncogene-driven
Hyein Jeon, Cheng, Haiying, Mumtu Lalla, Lalla, Mumtu, Jeon, Hyein, Yone, Nang, Nang Yone, Ahan Bhatt, Haiying Cheng, Bhatt, Ahan   +9 more
core   +1 more source

Hypoxia-triggered ERRα acetylation enhanced its oncogenic role and promoted progression of renal cell carcinoma by coordinating autophagosome-lysosome fusion

Cell Death and Disease
Estrogen-related receptor α (ERRα) is dysregulated in many types of cancer and exhibits oncogenic activity by promoting tumorigenesis and metastasis of cancer cells.
Chun Feng, Demin Kong, Binghua Tong, Yonghui Liang, Fuyi Xu, Yangyang Yang, Yingying Wu, Xiaodong Chi, Pengfei Wei, Yang Yang, Guilong Zhang, Geng Tian, Zhaowei Xu   +12 more
doaj   +1 more source

Clinical evaluation of two pathogen enrichment approaches for next-generation sequencing in the diagnosis of lower respiratory tract infections

Microbiology Spectrum
The underdevelopment of microbiological tests has contributed to diagnostic delay and inappropriate use of antibiotics in patients with lower respiratory tract infections, which is ranked as the seventh leading cause of death globally.
Xiao Lei, Xiumei Xu, Chao Liu, Lipeng Zhong, Shupeng Yin, Biaoxian Li, Ling Cao, Zhiting Xie, Jing Li, Xuan Zhang, Yaping Guo, Liang Zhang, Haiyan Lin, Sufeng Zhang, Chengsheng Zhang, Tian Gong   +15 more
doaj   +1 more source

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

FEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová, Grigorii Rakhalskii, Miroslav Almáši   +2 more
wiley   +1 more source

Hydrostatic pressure activates HIF‐1α via β‐catenin to promote stemness in breast cancer cells

FEBS Open Bio, EarlyView.
To mimic the elevated intestinal fluid pressure in breast cancers, we loaded human breast cancer cells (MCF‐7, MDA‐MB‐453, and BT‐474) to 50 mmHg hydrostatic pressure. Hydrostatic pressure exposure upregulated HIF‐1α and induced stemness in MCF‐7 and BT‐474 cells.
Da Zhai, Yong Xu, Jingjing Ma, Ratchanee Duangrat, Chen Yan, Jingyan Liang, Hua Wei, Bin Jiang, Tao‐Sheng Li   +8 more
wiley   +1 more source

Self‐assembly multifunctional DNA tetrahedron for efficient elimination of antibiotic‐resistant bacteria

Aggregate
Antibiotic resistance is a major challenge in the clinical treatment of bacterial infectious diseases. Herein, we constructed a multifunctional DNA nanoplatform as a versatile carrier for bacteria‐specific delivery of clinical antibiotic ciprofloxacin ...
Tiantian Wu, Yu Fu, Shuang Guo, Yanqiang Shi, Yuxin Zhang, Zhijin Fan, Bin Yang, Baoquan Ding, Yuhui Liao   +8 more
doaj   +1 more source

Aquaporin‐3 and aquaporin‐5 impact the development of pancreatic ductal adenocarcinoma spheroids

FEBS Open Bio, EarlyView.
Schematic representation of the role of aquaporin‐3 (AQP3) and aquaporin‐5 (AQP5) in pancreatic ductal adenocarcinoma (PDAC). Both proteins are upregulated in PDAC and are associated with tumor progression and metastatic potential. Silencing AQP3 or AQP5 in PDAC spheroids results in decreased diameter, area, and overall growth, underscoring their key ...
Catarina Pimpão, Diogo M. Engrácia, Graça Soveral, Filipa Mendes   +3 more
wiley   +1 more source

Transforming Gastrointestinal Diagnosis with Molecular Endoscopy: Challenges and Opportunities

Molecular endoscopy represents a transformative advance in the detection, diagnosis, and management of gastrointestinal diseases, addressing the critical limitations of conventional techniques. Current diagnostic standards, such as white light endoscopy (
Fuccio, Lorenzo, Sara Massironi, Giuseppe Dell’Anna, Centanni, Lucia, Federica Furfaro, Francesco Mandarino, Lorenzo Fuccio, Federica Ungaro, Massironi, Sara, Fasulo, Ernesto, Alberto Malesci, Tommaso Lorenzo Parigi, Mandarino, Francesco, Bencardino, Sarah, Silvio Danese, Furfaro, Federica, Dell'Anna, Giuseppe, Facciorusso, Antonio, Ungaro, Federica, Vito Annese, Fanizza, Jacopo, Ilaria Lodola, Jacopo Fanizza, Sarah Bencardino, Ernesto Fasulo, Lodola, Ilaria, Parigi, Tommaso Lorenzo, Annese, Vito, D'Amico, Ferdinando, Danese, Silvio, Lucia Centanni, Ferdinando D’Amico, Antonio Facciorusso, Gianfranco Donatelli, Donatelli, Gianfranco, Malesci, Alberto   +35 more
core   +1 more source