Results 11 to 20 of about 977,473 (267)

The inverted pattern of circulating miR-221-3p and miR-222-3p associated with isolated low HDL-C phenotype

Lipids in Health and Disease, 2018
Background We investigated the baseline characterization of cardiovascular disease (CVD)-derived circulating miR-221-3p/222-3p in isolated low HDL-C phenotype (ILHP) to enhance our understanding on their molecular pathological pattern prior to disease ...
Yuntao Zhou, Mengdi Liu, Jinrong Li, Bing Wu, Wei Tian, Lu Shi, Jing Zhang, Zening Sun   +7 more
doaj   +1 more source

Small intestinal bacterial overgrowth as a cause of protracted wound healing and vitamin D deficiency in a spinal cord injured patient with a sacral pressure sore: a case report

BMC Gastroenterology, 2020
Background Pressure sores are sometimes refractory to treatment, often due to malnutrition. Small intestinal bacterial overgrowth (SIBO) obstructs absorption in the digestive tract and causes malnutrition.
Yoshitaka Kubota, Hidekazu Nagano, Kentaro Ishii, Takashi Kono, Satomi Kono, Shinsuke Akita, Nobuyuki Mitsukawa, Tomoaki Tanaka   +7 more
doaj   +1 more source

Albinism: modern molecular diagnosis [PDF]

British Journal of Ophthalmology, 1998
Albinism is no longer a clinical diagnosis. The past classification of albinism was predicated on phenotypic expression, but now molecular biology has defined the condition more accurately. With recent advances in molecular research, it is possible to diagnose many of the various albinism conditions on the basis of genetic causation. This article seeks
S M, Carden, R E, Boissy, P J, Schoettker, W V, Good   +3 more
openaire   +2 more sources

Treatment patterns and outcomes in older women with early breast cancer: a population-based cohort study in China

BMC Cancer, 2021
Background Despite the proportion of elderly breast cancer patients has been consistently increasing, the optimal treatment modalities for this population have not been well explored. We summarized the treatment outcomes of these patients in our hospital.
Xu Liu, Dan Zheng, Yanqi Wu, Chuanxu Luo, Yu Fan, Xiaorong Zhong, Hong Zheng   +6 more
doaj   +1 more source

Proteogenomic landscape and clinical characterization of GH-producing pituitary adenomas/somatotroph pituitary neuroendocrine tumors

Communications Biology, 2022
The genetic alterations, protein expressions, and clinical characteristics of growth hormone-producing pituitary adenomas/somatotroph pituitary neuroendocrine tumors are integrated to detect molecules associated with acromegaly characteristics.
Azusa Yamato, Hidekazu Nagano, Yue Gao, Tatsuma Matsuda, Naoko Hashimoto, Akitoshi Nakayama, Kazuyuki Yamagata, Masataka Yokoyama, Yingbo Gong, Xiaoyan Shi, Siti Nurul Zhahara, Takashi Kono, Yuki Taki, Naoto Furuki, Motoi Nishimura, Kentaro Horiguchi, Yasuo Iwadate, Masaki Fukuyo, Bahityar Rahmutulla, Atsushi Kaneda, Yoshinori Hasegawa, Yusuke Kawashima, Osamu Ohara, Tetsuo Ishikawa, Eiryo Kawakami, Yasuhiro Nakamura, Naoko Inoshita, Shozo Yamada, Noriaki Fukuhara, Hiroshi Nishioka, Tomoaki Tanaka   +30 more
doaj   +1 more source

PDGFB targeting biodegradable FePt alloy assembly for MRI guided starvation-enhancing chemodynamic therapy of cancer

Journal of Nanobiotechnology, 2022
The application of chemodynamic therapy (CDT) for cancer is a serious challenge owing to the low efficiency of the Fenton catalyst and insufficient H2O2 expression in cells.
Caiyun Zhang, Zhiguo Leng, Yinfeng Wang, Lang Ran, Xia Qin, Huan Xin, Xiaotong Xu, Guilong Zhang, Zhaowei Xu   +8 more
doaj   +1 more source

Pyroptosis-Related Subtypes Predict the Response of Clear Cell Renal Cell Carcinoma to Targeted Therapy

Frontiers in Bioscience-Landmark, 2023
Background: Pyroptosis plays a crucial role in anti-tumor immunity and in formation of the immune microenvironment. However, whether pyroptosis is involved in the progression of clear cell renal cell carcinoma (ccRCC) is still unclear.
Jinpeng Ma, Zhijian Kang, Guang Yang, Xinyue Wang, Minggui Si, Yuting Wang, Guangbin Li, Shiyu Bai, Fanshu Zeng, Min Li, Ziqi Wang, Lu Wang, Wanhai Xu   +12 more
doaj   +1 more source

Acetylation of Checkpoint suppressor 1 enhances its stability and promotes the progression of triple-negative breast cancer

Cell Death Discovery, 2022
Checkpoint suppressor 1 (CHES1), a transcriptional regulator, had been dysregulated in many types of malignancies including breast cancer, and its expression level is strongly associated with progression and prognosis of patients. However, the underlying
Zhaowei Xu, Shuyan Liu, Chun Feng, Fuyi Xu, Demin Kong, Jia Mi, Chunhua Yang, Guilong Zhang, Pengfei Wei, Buyan-Ochir Orgil, Jonas Bergquist, Geng Tian   +11 more
doaj   +1 more source

Neuroradiological, genetic and clinical characteristics of histone H3 K27-mutant diffuse midline gliomas in the Kansai Molecular Diagnosis Network for CNS Tumors (Kansai Network): multicenter retrospective cohort

Acta Neuropathologica Communications
This study aims to elucidate the clinical and molecular characteristics, treatment outcomes and prognostic factors of patients with histone H3 K27-mutant diffuse midline glioma.
Nobuhide Hayashi, Junya Fukai, Hirokazu Nakatogawa, Hiroshi Kawaji, Ema Yoshioka, Yoshinori Kodama, Kosuke Nakajo, Takehiro Uda, Kentaro Naito, Noriyuki Kijima, Yoshiko Okita, Naoki Kagawa, Yoshinobu Takahashi, Naoya Hashimoto, Hideyuki Arita, Koji Takano, Daisuke Sakamoto, Tomoko Iida, Yoshiki Arakawa, Takeshi Kawauchi, Yukihiko Sonoda, Yuta Mitobe, Kenichi Ishibashi, Masahide Matsuda, Takamune Achiha, Takahiro Tomita, Masahiro Nonaka, Keijiro Hara, Noriyoshi Takebe, Takashi Tsuzuki, Yoshikazu Nakajima, Shiro Ohue, Nobuyuki Nakajima, Akira Watanabe, Akihiro Inoue, Masao Umegaki, Daisuke Kanematsu, Asako Katsuma, Miho Sumida, Tomoko Shofuda, Masayuki Mano, Manabu Kinoshita, Kanji Mori, Naoyuki Nakao, Yonehiro Kanemura   +44 more
doaj   +1 more source

Molecular diagnosis of sepsis

Expert Opinion on Medical Diagnostics, 2012
Current management of sepsis relies on the early detection and early administration of antimicrobials. This requires detection of pathogens earlier than conventional blood cultures and recognition of the immune status of the host earlier than the conventional biomarkers.
Kotsaki, A., Giamarellos-Bourboulis, E.J.   +1 more
openaire   +3 more sources