Results 21 to 30 of about 1,774,415 (209)

Treatment patterns and outcomes in older women with early breast cancer: a population-based cohort study in China

BMC Cancer, 2021
Background Despite the proportion of elderly breast cancer patients has been consistently increasing, the optimal treatment modalities for this population have not been well explored. We summarized the treatment outcomes of these patients in our hospital.
Xu Liu, Dan Zheng, Yanqi Wu, Chuanxu Luo, Yu Fan, Xiaorong Zhong, Hong Zheng   +6 more
doaj   +1 more source

A practical algorithmic approach to mature aggressive B cell lymphoma diagnosis in the double/triple hit era. Selecting cases, matching clinical benefit. A position paper from the Italian Group of Haematopathology (G.I.E.) [PDF]

, 2019
An accurate diagnosis of clinically distinct subgroups of aggressive mature B cell lymphomas is crucial for the choice of proper treatment. Presently, precise recognition of these disorders relies on the combination of morphological, immunophenotypical ...
Agostinelli, C., Ambrosio, M. R., Ascani, S., Carbone, A., Di Napoli, A., Facchetti, F., Lazzi, S., Leoncini, L., Lucioni, M., Novero, D., Paulli, M., Pileri, S., Ponzoni, M., Remotti, D., Ruco, L., Sabattini, E., Tripodo, C., Zamo, A.   +17 more
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Atypical presentation of neuronal ceroid lipofuscinosis type 8 in a sibling pair and review of the eye findings and neurological features. [PDF]

, 2016
Purpose:To report atypical presentation of neuronal ceroid lipofuscinoses type 8 (CLN8) to the eye clinic and review clinical features of CLN8. Observations:Detailed eye exam by slit lamp exam, indirect ophthalmoscopy, fundus photography, optical ...
Collins, Christin D, Mierau, Gary, Richards, Sarah, Sanchez, Rossana L, Shankar, Suma P, Wartchow, Eric P, Yan, Jiong   +6 more
core   +2 more sources

Proteogenomic landscape and clinical characterization of GH-producing pituitary adenomas/somatotroph pituitary neuroendocrine tumors

Communications Biology, 2022
The genetic alterations, protein expressions, and clinical characteristics of growth hormone-producing pituitary adenomas/somatotroph pituitary neuroendocrine tumors are integrated to detect molecules associated with acromegaly characteristics.
Azusa Yamato, Hidekazu Nagano, Yue Gao, Tatsuma Matsuda, Naoko Hashimoto, Akitoshi Nakayama, Kazuyuki Yamagata, Masataka Yokoyama, Yingbo Gong, Xiaoyan Shi, Siti Nurul Zhahara, Takashi Kono, Yuki Taki, Naoto Furuki, Motoi Nishimura, Kentaro Horiguchi, Yasuo Iwadate, Masaki Fukuyo, Bahityar Rahmutulla, Atsushi Kaneda, Yoshinori Hasegawa, Yusuke Kawashima, Osamu Ohara, Tetsuo Ishikawa, Eiryo Kawakami, Yasuhiro Nakamura, Naoko Inoshita, Shozo Yamada, Noriaki Fukuhara, Hiroshi Nishioka, Tomoaki Tanaka   +30 more
doaj   +1 more source

The burden of congenital Chagas disease and implementation of molecular diagnostic tools in Latin America [PDF]

, 2018
It is estimated that between 8000 and 15 000 Trypanosoma cruzi infected babies are born every year to infected mothers in Chagas disease endemic countries. Currently, poor access to and performance of the current diagnostic algorithm, based on microscopy
Cruz, Israel, Katz, Zachary, Ndung'u, Joseph Mathu, Picado, Albert, Redard Jacot, Maël, Schijman, Alejandro Gabriel, Sosa-Estani, Sergio Alejandro, Torrico, Faustino   +7 more
core   +1 more source

PDGFB targeting biodegradable FePt alloy assembly for MRI guided starvation-enhancing chemodynamic therapy of cancer

Journal of Nanobiotechnology, 2022
The application of chemodynamic therapy (CDT) for cancer is a serious challenge owing to the low efficiency of the Fenton catalyst and insufficient H2O2 expression in cells.
Caiyun Zhang, Zhiguo Leng, Yinfeng Wang, Lang Ran, Xia Qin, Huan Xin, Xiaotong Xu, Guilong Zhang, Zhaowei Xu   +8 more
doaj   +1 more source

The pathogenesis of tendinopathy. A molecular perspective [PDF]

, 2004
There are many publications that discuss the aetiology, diagnosis and treatment of the various forms of tendinopathy, but few are based on conclusive scientific evidence.
Riley, GP
core   +1 more source

Pyroptosis-Related Subtypes Predict the Response of Clear Cell Renal Cell Carcinoma to Targeted Therapy

Frontiers in Bioscience-Landmark, 2023
Background: Pyroptosis plays a crucial role in anti-tumor immunity and in formation of the immune microenvironment. However, whether pyroptosis is involved in the progression of clear cell renal cell carcinoma (ccRCC) is still unclear.
Jinpeng Ma, Zhijian Kang, Guang Yang, Xinyue Wang, Minggui Si, Yuting Wang, Guangbin Li, Shiyu Bai, Fanshu Zeng, Min Li, Ziqi Wang, Lu Wang, Wanhai Xu   +12 more
doaj   +1 more source

Molecular diagnosis of haemophilia A: four novel variants identified in five patients [PDF]

, 2020
Aims/Context: Haemophilia A (HMA) is an X-linked bleeding disorder caused by reduced levels of the coagulation factor VIII (FVIII) due to alterations in the F8 gene. Decreased levels of FVIII activity leads to a loss of clotting activity and to bleeding (
Antunes, Ema, Certã, Rita, Cruz, Eugénia, Diniz, Maria João, Gonçalves, João, Kjollerstrom, Paula, Morais, Sara, Moreira, Isabel   +7 more
core  

Acetylation of Checkpoint suppressor 1 enhances its stability and promotes the progression of triple-negative breast cancer

Cell Death Discovery, 2022
Checkpoint suppressor 1 (CHES1), a transcriptional regulator, had been dysregulated in many types of malignancies including breast cancer, and its expression level is strongly associated with progression and prognosis of patients. However, the underlying
Zhaowei Xu, Shuyan Liu, Chun Feng, Fuyi Xu, Demin Kong, Jia Mi, Chunhua Yang, Guilong Zhang, Pengfei Wei, Buyan-Ochir Orgil, Jonas Bergquist, Geng Tian   +11 more
doaj   +1 more source