Results 51 to 60 of about 319,160 (295)

Evaluation of tuberculosis diagnostics: establishing an evidence base around the public health impact. [PDF]

, 2011
The limitations of existing tuberculosis diagnostic tools are significantly hampering tuberculosis control efforts, most noticeably in areas with high prevalence of human immunodeficiency virus (HIV) infection and antituberculosis drug resistance ...
Newell, Marie-Louise, Graham S. Cooke, Marie-Louise Newell, Cooke, Graham S, Peter Godfrey-Faussett, Richard J. Lessells, Lessells, Richard J, Godfrey-Faussett, Peter   +7 more
core   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Prevalence and distribution of dengue virus serotypes among seropositive patients at a tertiary care center: A retrospective study

Journal of Indira Gandhi Institute of Medical Sciences
Introduction: Dengue fever, a significant public health threat in tropical and subtropical regions, is caused by any of the five dengue virus serotypes (DENV-1 to DENV-5).
Nusrat Jahan, Nidhi Prasad, Bhim Ram, Kalichamy Alagarasu, Shishir Kumar, Vidyut Prakash, Shivani Agrawal   +6 more
doaj   +1 more source

Applications of Molecular Diagnostic Techniques for Infectious Diseases

, 2014
Diagnosis is concerned with identifying the cause of a disease or precise and consistent outcomes that are results of direct or indirect actions, reactions and interactions between the cause of a disease and the host.
Manu, AY, Sarkinfada, F, Auwal, I
core   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

From phenotypic to molecular diagnosis: Insights from a clinical immunology service focused on inborn errors of immunity in Colombia

Biomédica: revista del Instituto Nacional de Salud
Introduction. Inborn errors of immunity include a broad spectrum of genetic diseases, in which a specific gene mutation might alter the entire emphasis and approach for an individual patient. Objective.
Mónica Fernandes Pineda, Andrés F. Zea-Vera   +1 more
doaj   +1 more source

Advanced clinical diagnostic techniques: omics and their application to the molecular study of diseases [PDF]

, 2023
El document forma part dels materials docents programats mitjançant l'ajut del Servei de Política Lingüística de la Universitat de ValènciaOmics development is allowing to improve clinical diagnostic techniques in clinical biochemistry. Omics investigate
Galán Albiñana, Amparo
core  

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Molecular techniques for cancer diagnostics

Academia Medicine
Cancer cells differ from healthy tissues in their biological makeup. Recent research reported vast genetic and epigenetic heterogeneity, differences in the gene-expression profiles, and signal transduction networks in a broad range of cancers. These discoveries led to the development and clinical approval of several drugs that are more efficient and ...
Vimal Kishor Singh, Ramesh Chandra
openaire   +2 more sources

The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes

FEBS Letters, EarlyView.
Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga, Toshiki Takahashi, Akiko Kuma, Hiroyuki Kawahara   +3 more
wiley   +1 more source