Results 91 to 100 of about 424,818 (305)

Transparency of Reporting in Molecular Diagnostics [PDF]

International Journal of Molecular Sciences, 2013
The major advances made over the past few years in molecular and cell biology are providing a progressively more detailed understanding of the molecular pathways that control normal processes and become dysregulated in disease [1]. This has resulted in the documentation of numerous genetic, epigenetic, transcriptomic, proteomic and metabolomic ...
openaire   +2 more sources

Periodontal Molecular Diagnostics: State of Knowledge and Future Prospects for Clinical Application

Periodontitis leads to immunologically mediated loss of periodontium and, if untreated, can result in tooth loss. Periodontal diseases are the most prevalent in the world and have a very strong impact on patients’ well-being and general health ...
Ewa Dolińska, Patryk Wiśniewski, Małgorzata Pietruska   +2 more
core   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Joint associations of smartphone use and gender on multidimensional cognitive health among community-dwelling older adults: a cross-sectional study

BMC Geriatrics, 2019
Background Smartphone use has become an increasingly pervasive part of our daily lives, and as a portable media device, smartphones provide good support for cognitive training during aging.
Manqiong Yuan, Jia Chen, Zi Zhou, Jiahui Yin, Jielong Wu, Mingliang Luo, Lixia Wang, Ya Fang   +7 more
doaj   +1 more source

Research Progress of Anti-cancer Drug Delivery System Based on Silica Nanoparticles

Zhongliu Fangzhi Yanjiu, 2020
In recent years, more and more attention has been paid to the development of cancer diagnosis and treatment, including nanoparticles-based methods. Silica nanoparticles show great potential in the field of tumor diagnosis and treatment because of its ...
ZHENG Weibin, ZHANG Boya, YIN Xiaochen, WANG Xin, ZHAO Qinjian   +4 more
doaj   +1 more source

Molecular Diagnostics and Personalized Therapeutics in Differentiated Thyroid Carcinoma: A Clinically Oriented Review. [PDF]

Diagnostics (Basel)
Differentiated thyroid carcinoma (DTC) is the most common endocrine malignancy and typically has a favorable prognosis. However, a subset of patients experience aggressive disease, recurrence, or treatment resistance, underscoring the need for more ...
Coca-Pelaz A, Rodrigo JP, Zafereo M, Nixon I, Pace-Asciak P, Randolph GW, Suárez C, Ferlito A.   +7 more
europepmc   +2 more sources

PARK(ing) time–How park deficiency affects the biological clock in a Drosophila model of Parkinson's disease

FEBS Letters, EarlyView.
Drosophila park mutants serve as a model for Parkinson's disease. We used this strain to investigate the connection between oxidative stress and the circadian clock mechanism. We showed that increased oxidative stress affects the physiology of pacemaker cells, disrupting their daily structural plasticity. Lack of rhythmic signaling from pacemaker cells
Kamila Zientara, Kinga Skoczek, Elzbieta Pyza, Milena Damulewicz   +3 more
wiley   +1 more source

A five-compartment model of age-specific transmissibility of SARS-CoV-2

Infectious Diseases of Poverty, 2020
Background The novel coronavirus, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2, also called 2019-nCoV) causes different morbidity risks to individuals in different age groups.
Ze-Yu Zhao, Yuan-Zhao Zhu, Jing-Wen Xu, Shi-Xiong Hu, Qing-Qing Hu, Zhao Lei, Jia Rui, Xing-Chun Liu, Yao Wang, Meng Yang, Li Luo, Shan-Shan Yu, Jia Li, Ruo-Yun Liu, Fang Xie, Ying-Ying Su, Yi-Chen Chiang, Ben-Hua Zhao, Jing-An Cui, Ling Yin, Yan-Hua Su, Qing-Long Zhao, Li-Dong Gao, Tian-Mu Chen   +23 more
doaj   +1 more source

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

FEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee, Junho Jeong, Chae Yeong Lee, Hyunjoon Cho, Man Hwan Oh, Je Chul Lee, Jee‐Young Lee, Yangmee Kim   +7 more
wiley   +1 more source

Targeting SUMOylation in glioblastoma: A novel avenue for therapy and biomarker discovery

Genes and Diseases
SUMOylation, a post-translational protein modification, plays a crucial role in regulating various biological processes. Dysregulation of SUMOylation has been linked to glioblastoma progression, impacting key signaling pathways.
Wiktoria Dubanosow, Bartosz Lenda, Marta Żebrowska-Nawrocka, Dagmara Szmajda-Krygier, Rafał Świechowski, Ewa Balcerczak   +5 more
doaj   +1 more source