Results 101 to 110 of about 7,339,385 (306)

Efficient intracellular delivery of proteins by a multifunctional chimaeric peptide in vitro and in vivo

Nature Communications, 2021
Protein delivery with cell-penetrating peptides suffers from ineffective endosomal escape and low tolerance in serum, thereby limiting treatment success. Here the authors present an intracellular protein delivery system and demonstrate efficient delivery
Siyuan Yu, Han Yang, Tingdong Li, Haifeng Pan, Shuling Ren, Guoxing Luo, Jinlu Jiang, Linqi Yu, Binbing Chen, Yali Zhang, Shaojuan Wang, Rui Tian, Tianying Zhang, Shiyin Zhang, Yixin Chen, Quan Yuan, Shengxiang Ge, Jun Zhang, Ningshao Xia   +18 more
doaj   +1 more source

Measurement of tumor mutational burden (TMB) in routine molecular diagnostics: in silico and real‐life analysis of three larger gene panels

International Journal of Cancer, 2019
Assessment of Tumor Mutational Burden (TMB) for response stratification of cancer patients treated with immune checkpoint inhibitors is emerging as a new biomarker.
V. Endris, I. Buchhalter, M. Allgäuer, E. Rempel, A. Lier, A. Volckmar, M. Kirchner, M. von Winterfeld, J. Leichsenring, O. Neumann, R. Penzel, W. Weichert, H. Glimm, S. Fröhling, H. Winter, F. Herth, Michael Thomas, P. Schirmacher, J. Budczies, A. Stenzinger   +19 more
semanticscholar   +1 more source

Impact of Japan's 2024 Physician Work‐Style Reform on Pediatric Hematology–Oncology: Educational Implications in a 2‐Year Survey

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Japan's 2024 physician work‐style reform introduced legally binding limits on physicians’ working hours, but its impact on education and workforce sustainability in pediatric hematology–oncology (PHO) remains unclear. Procedure We conducted a repeated cross‐sectional study with structured quantitative items and free‐text responses ...
Kiyohiko Kaizu, Masaharu Akiyama, Toshikazu Itabashi, Jun Hayakawa, Takahiro Kikuchi, Ryohei Fukunaga, Katsuyoshi Koh, Takahiro Ueda   +7 more
wiley   +1 more source

Transparency of Reporting in Molecular Diagnostics [PDF]

International Journal of Molecular Sciences, 2013
The major advances made over the past few years in molecular and cell biology are providing a progressively more detailed understanding of the molecular pathways that control normal processes and become dysregulated in disease [1]. This has resulted in the documentation of numerous genetic, epigenetic, transcriptomic, proteomic and metabolomic ...
openaire   +2 more sources

Comparative Evaluation of Hemodiafiltration, Hemoperfusion, and Standard Hemodialysis on Efficacy, Inflammatory Control, Dialysis Adequacy, and Safety in End‐Stage Renal Disease: A Prospective Observational Study

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Background Chronic micro‐inflammation in patients with end‐stage renal disease (ESRD) is a significant driver of cardiovascular complications and diminished quality of life. While standard hemodialysis (SHD) effectively manages small‐molecule clearance, its ability to remove medium‐to‐large uremic toxins—the primary catalysts of systemic ...
Hongwei Zuo, Weisi Dai, Jie Mao, Mei Ye, Xingshan Lu, Xiaocui Zhang   +5 more
wiley   +1 more source

Joint associations of smartphone use and gender on multidimensional cognitive health among community-dwelling older adults: a cross-sectional study

BMC Geriatrics, 2019
Background Smartphone use has become an increasingly pervasive part of our daily lives, and as a portable media device, smartphones provide good support for cognitive training during aging.
Manqiong Yuan, Jia Chen, Zi Zhou, Jiahui Yin, Jielong Wu, Mingliang Luo, Lixia Wang, Ya Fang   +7 more
doaj   +1 more source

Current Update of Laboratory Molecular Diagnostics Advancement in Management of Colorectal Cancer (CRC)

Diagnostics, 2019
Colorectal cancer (CRC) continues to be one of the most common cancers globally. The incidence has increased in developing countries in the past few decades, this could be partly attributed to aging populations and unhealthy lifestyles.
S. Pang, N. J. Awi, S. Armon, Wendy Wan Dee Lim, J. Low, K. Peh, S. Peh, Sin-Yeang Teow   +7 more
semanticscholar   +1 more source

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Targeting SUMOylation in glioblastoma: A novel avenue for therapy and biomarker discovery

Genes and Diseases
SUMOylation, a post-translational protein modification, plays a crucial role in regulating various biological processes. Dysregulation of SUMOylation has been linked to glioblastoma progression, impacting key signaling pathways.
Wiktoria Dubanosow, Bartosz Lenda, Marta Żebrowska-Nawrocka, Dagmara Szmajda-Krygier, Rafał Świechowski, Ewa Balcerczak   +5 more
doaj   +1 more source

Research Progress of Anti-cancer Drug Delivery System Based on Silica Nanoparticles

Zhongliu Fangzhi Yanjiu, 2020
In recent years, more and more attention has been paid to the development of cancer diagnosis and treatment, including nanoparticles-based methods. Silica nanoparticles show great potential in the field of tumor diagnosis and treatment because of its ...
ZHENG Weibin, ZHANG Boya, YIN Xiaochen, WANG Xin, ZHAO Qinjian   +4 more
doaj   +1 more source